Intraoperative vascular anastomosis occlusion due to cold agglutinin disease during brain surgery: a case report
Abstract Background Cold agglutinin disease (CAD) is an autoimmune hemolytic anemia that induces blood coagulation and hemolysis upon exposure to cold temperatures. Strict temperature control is essential to mitigate these effects, especially during surgical procedures where hypothermia is possible....
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SpringerOpen
2025-01-01
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| Series: | JA Clinical Reports |
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| Online Access: | https://doi.org/10.1186/s40981-025-00766-z |
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| author | Kazuma Kitamura Mayumi Nakanishi Naokazu Fukuoka Kumiko Tanabe Yoshinori Kamiya |
| author_facet | Kazuma Kitamura Mayumi Nakanishi Naokazu Fukuoka Kumiko Tanabe Yoshinori Kamiya |
| author_sort | Kazuma Kitamura |
| collection | DOAJ |
| description | Abstract Background Cold agglutinin disease (CAD) is an autoimmune hemolytic anemia that induces blood coagulation and hemolysis upon exposure to cold temperatures. Strict temperature control is essential to mitigate these effects, especially during surgical procedures where hypothermia is possible. Case presentation A 57-year-old male, 165 cm and 72 kg, diagnosed with CAD, underwent cerebral vascular anastomosis. Intraoperatively, mean arterial pressure was maintained at or above 65 mmHg with phenylephrine administration, while body temperature was rigorously controlled between 36.5 °C and 37.5 °C using forced-air warming blankets and heated intravenous infusions. Despite these measures, thrombotic occlusion occurred, necessitating surgical thrombus removal, intravenous heparin administration, and irrigation of the surgical field with warmed saline followed by re-anastomosis. The anastomosis remained patent without recurrence of thrombus formation thereafter. Conclusion Preventing hypothermia is extremely important in the anesthesia management of CAD patients. However, careful attention must also be paid to temperature regulation in the surgical field. |
| format | Article |
| id | doaj-art-84bb73983fbb4593818cec3df709f712 |
| institution | Kabale University |
| issn | 2363-9024 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | JA Clinical Reports |
| spelling | doaj-art-84bb73983fbb4593818cec3df709f7122025-01-19T12:13:20ZengSpringerOpenJA Clinical Reports2363-90242025-01-011111410.1186/s40981-025-00766-zIntraoperative vascular anastomosis occlusion due to cold agglutinin disease during brain surgery: a case reportKazuma Kitamura0Mayumi Nakanishi1Naokazu Fukuoka2Kumiko Tanabe3Yoshinori Kamiya4Department of Anesthesiology and Pain Medicine, Gifu University HospitalDepartment of Anesthesiology and Pain Medicine, Gifu University HospitalDepartment of Anesthesiology and Pain Medicine, Gifu University HospitalDepartment of Anesthesiology and Pain Medicine, Gifu University HospitalDepartment of Anesthesiology and Pain Medicine, Gifu University HospitalAbstract Background Cold agglutinin disease (CAD) is an autoimmune hemolytic anemia that induces blood coagulation and hemolysis upon exposure to cold temperatures. Strict temperature control is essential to mitigate these effects, especially during surgical procedures where hypothermia is possible. Case presentation A 57-year-old male, 165 cm and 72 kg, diagnosed with CAD, underwent cerebral vascular anastomosis. Intraoperatively, mean arterial pressure was maintained at or above 65 mmHg with phenylephrine administration, while body temperature was rigorously controlled between 36.5 °C and 37.5 °C using forced-air warming blankets and heated intravenous infusions. Despite these measures, thrombotic occlusion occurred, necessitating surgical thrombus removal, intravenous heparin administration, and irrigation of the surgical field with warmed saline followed by re-anastomosis. The anastomosis remained patent without recurrence of thrombus formation thereafter. Conclusion Preventing hypothermia is extremely important in the anesthesia management of CAD patients. However, careful attention must also be paid to temperature regulation in the surgical field.https://doi.org/10.1186/s40981-025-00766-zCold agglutinin diseaseVascular anastomosisBrain surgeryBody temperatureLocal warming |
| spellingShingle | Kazuma Kitamura Mayumi Nakanishi Naokazu Fukuoka Kumiko Tanabe Yoshinori Kamiya Intraoperative vascular anastomosis occlusion due to cold agglutinin disease during brain surgery: a case report JA Clinical Reports Cold agglutinin disease Vascular anastomosis Brain surgery Body temperature Local warming |
| title | Intraoperative vascular anastomosis occlusion due to cold agglutinin disease during brain surgery: a case report |
| title_full | Intraoperative vascular anastomosis occlusion due to cold agglutinin disease during brain surgery: a case report |
| title_fullStr | Intraoperative vascular anastomosis occlusion due to cold agglutinin disease during brain surgery: a case report |
| title_full_unstemmed | Intraoperative vascular anastomosis occlusion due to cold agglutinin disease during brain surgery: a case report |
| title_short | Intraoperative vascular anastomosis occlusion due to cold agglutinin disease during brain surgery: a case report |
| title_sort | intraoperative vascular anastomosis occlusion due to cold agglutinin disease during brain surgery a case report |
| topic | Cold agglutinin disease Vascular anastomosis Brain surgery Body temperature Local warming |
| url | https://doi.org/10.1186/s40981-025-00766-z |
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