Fragment Screening Reveals Novel Scaffolds against Sirtuin-2-Related Protein 1 from Trypanosoma brucei

Fragment Screening Reveals Novel Scaffolds against Sirtuin-2-Related Protein 1 from Trypanosoma brucei

Saved in:

Bibliographic Details
Main Authors:	Renan A. Gomes, Marcelo D. Polêto, Hugo Verli, Vitor M. Almeida, Sandro R. Marana, Andreas Bender, Bruna F. Godoi, Vinícius T. L. Rodrigues, Flavio da S. Emery, Gustavo H. G. Trossini
Format:	Article
Language:	English
Published:	American Chemical Society 2024-12-01
Series:	ACS Omega
Online Access:	https://doi.org/10.1021/acsomega.4c09231
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

In Vitro Mechanism of Action of Acanthospermum hispidum in Trypanosoma brucei
by: Aboagye Kwarteng Dofuor, et al.
Published: (2022-01-01)

A murine model of Trypanosoma brucei-induced myocarditis and cardiac dysfunction
by: Nathan P. Crilly, et al.
Published: (2025-02-01)

Structural basis of Spliced Leader RNA recognition by the Trypanosoma brucei cap-binding complex
by: Harald Bernhard, et al.
Published: (2025-01-01)

Mono-allelic epigenetic regulation of polycistronic transcription initiation by RNA polymerase II in Trypanosoma brucei
by: Rudo Kieft, et al.
Published: (2025-02-01)

IL-6 is Upregulated in Late-Stage Disease in Monkeys Experimentally Infected with Trypanosoma brucei rhodesiense
by: Dawn Nyawira Maranga, et al.
Published: (2013-01-01)

Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei
by: Marija Krasiļņikova, et al.
Published: (2025-01-01)

Silent Human Trypanosoma brucei gambiense Infections around the Old Gboko Sleeping Sickness Focus in Nigeria
by: Karshima Solomon Ngutor, et al.
Published: (2016-01-01)

Split-Cre-mediated GFP expression as a permanent marker for flagellar fusion of Trypanosoma brucei in its tsetse fly host
by: Ruth Etzensperger, et al.
Published: (2025-02-01)

Deep mutational scanning of the Trypanosoma brucei developmental regulator RBP6 reveals an essential disordered region influenced by positive residues
by: Saúl Rojas-Sánchez, et al.
Published: (2025-01-01)

Sirtuins, Bioageing, and Cancer
by: D. McGuinness, et al.
Published: (2011-01-01)

The Relationship of Sirtuin 1 and Sirtuin 2 Expression with Clinicopathological Parameters in Non Small-Cell Lung Carcinomas
by: Fatma Cakmak Kazanci, et al.
Published: (2024-11-01)

Sirtuin 1: A Dilemma in Transplantation
by: Sara Assadiasl, et al.
Published: (2020-01-01)

Prevalence of Trypanosoma congolense and Trypanosoma vivax in Lira District, Uganda
by: Aziz, Katabazi, et al.
Published: (2021)

Prevalence of Trypanosoma congolense and Trypanosoma vivax in Lira District, Uganda
by: Aziz, Katabazi, et al.
Published: (2021)

Sirtuin activators as an anti-aging intervention for longevity
by: Puja Sah, et al.
Published: (2025-01-01)

Comment on “Renal Protective Effect of Sirtuin 1”
by: Kultigin Turkmen
Published: (2015-01-01)

Emerging Evidence concerning the Role of Sirtuins in Sepsis
by: Lulan Li, et al.
Published: (2018-01-01)

Role of sirtuins in epigenetic regulation and aging control
by: E. M. Samoilova, et al.
Published: (2024-04-01)

Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus
by: Katarzyna Zgutka, et al.
Published: (2025-01-01)

Parasitological, Hematological, and Immunological Response of Experimentally Infected Sheep with Venezuelan Isolates of Trypanosoma evansi, Trypanosoma equiperdum, and Trypanosoma vivax
by: Nereida Parra-Gimenez, et al.
Published: (2019-01-01)

Mitochondrial Dysfunction and Sirtuins: Important Targets in Hearing Loss
by: Lingjun Zhang, et al.
Published: (2021-01-01)

Sirtuins in kidney homeostasis and disease: where are we now?
by: Zhongyu Fan, et al.
Published: (2025-01-01)

Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease
by: V. Conti, et al.
Published: (2015-01-01)

Immune Evasion Strategies of Trypanosoma cruzi
by: Ana Flávia Nardy, et al.
Published: (2015-01-01)

Alternative transmission modes for Trypanosoma cruzi
by: Christopher M. Kribs-Zaleta
Published: (2010-05-01)

Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD
by: Yao Xu, et al.
Published: (2025-01-01)

Partial Purification of Integral Membrane Antigenic Proteins from Trypanosoma evansi That Display Immunological Cross-Reactivity with Trypanosoma vivax
by: Norma P. Velásquez, et al.
Published: (2014-01-01)

Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration
by: Preeti Singh, et al.
Published: (2017-01-01)

Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice
by: Ayana N. Martin, et al.
Published: (2018-01-01)

Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development
by: Zhangmin Ke, et al.
Published: (2025-01-01)

Trypanosoma cruzi Infection and Host Lipid Metabolism
by: Qianqian Miao, et al.
Published: (2014-01-01)

Fragment by Fragment : feminist perspectives on memory and child sexual abuse /
Published: (1999)

Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission
by: Mário A. C. Silva-Neto, et al.
Published: (2012-01-01)

<i>Trypanosoma cruzi</i>: Genomic Diversity and Structure
by: Alfonso Herreros-Cabello, et al.
Published: (2025-01-01)

Mitochondrial DNA Structure in <i>Trypanosoma cruzi</i>
by: Alfonso Herreros-Cabello, et al.
Published: (2025-01-01)

Role of sirtuin 1 (SIRT1) gene polymorphisms in pituitary adenoma development. Literature review
by: G. Morkūnaitė, et al.
Published: (2018-06-01)

The clinical value of serum sirtuin-1 concentration in the diagnosis of metabolic dysfunction-associated steatotic liver disease
by: Farshad Amirkhizi, et al.
Published: (2025-01-01)

The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi
by: Marcia Cristina Paes, et al.
Published: (2011-01-01)

Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy
by: Eugenia Hovsepian, et al.
Published: (2012-01-01)

A Brief View of the Surface Membrane Proteins from Trypanosoma cruzi
by: Ángel de la Cruz Pech-Canul, et al.
Published: (2017-01-01)