Overcoming beta-lactam resistance in Pseudomonas aeruginosa by targeting metallo-beta-lactamase VIM-1: a one-microsecond molecular dynamics simulation study

Overcoming beta-lactam resistance in Pseudomonas aeruginosa by targeting metallo-beta-lactamase VIM-1: a one-microsecond molecular dynamics simulation study

Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen with a high resistance to beta-lactam antibiotics, mainly due to the production of metallo-beta-lactamase VIM-1 (MBL-VIM-1) enzyme. This study aimed to identify new inhibitors targeting MBL-VIM-1 to restore the efficacy...

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Bibliographic Details
Main Authors: Mohammed Salleh M. Ardawi, Samar A. Badreddine, Muhammad Yasir, Aiah M. Khateb, Safaa A. Turkistani, Ahmed Afandi, Samah O. Noor, Adhari Alselmi, Vivek Dhar Dwivedi, Esam I. Azhar
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
P. aeruginosa
metallo-beta-lactamase
VIM-1
beta-lactam antibiotics
drug discovery
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1521391/full
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