Cellular Response upon Stress: p57 Contribution to the Final Outcome
Progression through the cell cycle is one of the most important decisions during the life of a cell and several kinds of stress are able to influence this choice. p57 is a cyclin-dependent kinase inhibitor belonging to the CIP/KIP family and is a well-known regulator of the cell cycle during embryog...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/259325 |
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| author | Marianna Nicoletta Rossi Fabrizio Antonangeli |
| author_facet | Marianna Nicoletta Rossi Fabrizio Antonangeli |
| author_sort | Marianna Nicoletta Rossi |
| collection | DOAJ |
| description | Progression through the cell cycle is one of the most important decisions during the life of a cell and several kinds of stress are able to influence this choice. p57 is a cyclin-dependent kinase inhibitor belonging to the CIP/KIP family and is a well-known regulator of the cell cycle during embryogenesis and tissue differentiation. p57 loss has been reported in a variety of cancers and great effort has been spent during the past years studying the mechanisms of p57 regulation and the effects of p57 reexpression on tumor growth. Recently, growing amount of evidence points out that p57 has a specific function in cell cycle regulation upon cellular stress that is only partially shared by the other CIP/KIP inhibitors p21 and p27. Furthermore, it is nowadays emerging that p57 plays a role in the induction of apoptosis and senescence after cellular stress independently of its cell cycle related functions. This review focuses on the contribution that p57 holds in regulating cell cycle arrest, apoptosis, and senescence after cellular stress with particular attention to the response of cancer cells. |
| format | Article |
| id | doaj-art-84b465f01c414a36b3b262432611b6e5 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-84b465f01c414a36b3b262432611b6e52025-02-03T05:53:56ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/259325259325Cellular Response upon Stress: p57 Contribution to the Final OutcomeMarianna Nicoletta Rossi0Fabrizio Antonangeli1Department of Cellular Biotechnologies and Hematology, Pasteur Institute-Fondazione Cenci Bolognetti, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyDepartment of Molecular Medicine, Pasteur Institute-Fondazione Cenci Bolognetti, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, ItalyProgression through the cell cycle is one of the most important decisions during the life of a cell and several kinds of stress are able to influence this choice. p57 is a cyclin-dependent kinase inhibitor belonging to the CIP/KIP family and is a well-known regulator of the cell cycle during embryogenesis and tissue differentiation. p57 loss has been reported in a variety of cancers and great effort has been spent during the past years studying the mechanisms of p57 regulation and the effects of p57 reexpression on tumor growth. Recently, growing amount of evidence points out that p57 has a specific function in cell cycle regulation upon cellular stress that is only partially shared by the other CIP/KIP inhibitors p21 and p27. Furthermore, it is nowadays emerging that p57 plays a role in the induction of apoptosis and senescence after cellular stress independently of its cell cycle related functions. This review focuses on the contribution that p57 holds in regulating cell cycle arrest, apoptosis, and senescence after cellular stress with particular attention to the response of cancer cells.http://dx.doi.org/10.1155/2015/259325 |
| spellingShingle | Marianna Nicoletta Rossi Fabrizio Antonangeli Cellular Response upon Stress: p57 Contribution to the Final Outcome Mediators of Inflammation |
| title | Cellular Response upon Stress: p57 Contribution to the Final Outcome |
| title_full | Cellular Response upon Stress: p57 Contribution to the Final Outcome |
| title_fullStr | Cellular Response upon Stress: p57 Contribution to the Final Outcome |
| title_full_unstemmed | Cellular Response upon Stress: p57 Contribution to the Final Outcome |
| title_short | Cellular Response upon Stress: p57 Contribution to the Final Outcome |
| title_sort | cellular response upon stress p57 contribution to the final outcome |
| url | http://dx.doi.org/10.1155/2015/259325 |
| work_keys_str_mv | AT mariannanicolettarossi cellularresponseuponstressp57contributiontothefinaloutcome AT fabrizioantonangeli cellularresponseuponstressp57contributiontothefinaloutcome |