Corneal Nerve Parameter Reference Values for Chinese Adults Assessed by Corneal Confocal Microscopy
Background. Confocal corneal microscopy is an excellent new noninvasive tool for assessing diabetic peripheral neuropathy. We aimed to investigate the clinical variables associated with corneal nerve parameters and establish reference values for clinical use in healthy Chinese adults. Methods. The s...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2022/4913031 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550430099374080 |
|---|---|
| author | Juan Cao Jingru Qu Bekzod Odilov Bin Lu Yuanpin Zhang Lili Li Yuan Zhang Qian Xiong Yu Hong Jianqiao Li Yunfeng Shen Xinguo Hou |
| author_facet | Juan Cao Jingru Qu Bekzod Odilov Bin Lu Yuanpin Zhang Lili Li Yuan Zhang Qian Xiong Yu Hong Jianqiao Li Yunfeng Shen Xinguo Hou |
| author_sort | Juan Cao |
| collection | DOAJ |
| description | Background. Confocal corneal microscopy is an excellent new noninvasive tool for assessing diabetic peripheral neuropathy. We aimed to investigate the clinical variables associated with corneal nerve parameters and establish reference values for clinical use in healthy Chinese adults. Methods. The study enlisted 257 healthy volunteers (137 females and 120 males) from two clinical academic centers in China. Two experts captured and selected images of the central corneal subbasal nerve plexus at each center using the same corneal confocal microscopy instrument according to a commonly adopted protocol. Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), and corneal nerve fiber length (CNFL) were measured using fully automated software (ACCMetrics). The correlation between clinical indicators and confocal corneal microscopy measures was determined using partial correlation. Quantile regression was used to calculate reference values and estimate the effects of clinical factors on the normative values of confocal corneal microscopy measures. Results. Females had significantly higher CNFD, CNBD, and CNFL than males. There was no correlation between age, glycated hemoglobin (HbA1c), height, weight, body mass index (BMI), and any corneal nerve fiber parameter in both sexes. In either sex, age, weight, height, BMI, and HbA1c did not affect the 0.05th quantile values of any corneal nerve parameter. Conclusions. This study establishes sex-adjusted reference values for corneal confocal microscopy measures in Chinese adults and provides a reference for clinical practice and research with this technique. |
| format | Article |
| id | doaj-art-84b1ca3b22f043a39206de845dd1d496 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-84b1ca3b22f043a39206de845dd1d4962025-02-03T06:06:49ZengWileyJournal of Diabetes Research2314-67532022-01-01202210.1155/2022/4913031Corneal Nerve Parameter Reference Values for Chinese Adults Assessed by Corneal Confocal MicroscopyJuan Cao0Jingru Qu1Bekzod Odilov2Bin Lu3Yuanpin Zhang4Lili Li5Yuan Zhang6Qian Xiong7Yu Hong8Jianqiao Li9Yunfeng Shen10Xinguo Hou11Department of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of Endocrinology and MetabolismDepartment of Endocrinology and MetabolismDepartment of EndocrinologyClinical Epidemiology UnitDepartment of Endocrinology and MetabolismDepartment of Endocrinology and MetabolismDepartment of OphthalmologyDepartment of Endocrinology and MetabolismDepartment of EndocrinologyBackground. Confocal corneal microscopy is an excellent new noninvasive tool for assessing diabetic peripheral neuropathy. We aimed to investigate the clinical variables associated with corneal nerve parameters and establish reference values for clinical use in healthy Chinese adults. Methods. The study enlisted 257 healthy volunteers (137 females and 120 males) from two clinical academic centers in China. Two experts captured and selected images of the central corneal subbasal nerve plexus at each center using the same corneal confocal microscopy instrument according to a commonly adopted protocol. Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), and corneal nerve fiber length (CNFL) were measured using fully automated software (ACCMetrics). The correlation between clinical indicators and confocal corneal microscopy measures was determined using partial correlation. Quantile regression was used to calculate reference values and estimate the effects of clinical factors on the normative values of confocal corneal microscopy measures. Results. Females had significantly higher CNFD, CNBD, and CNFL than males. There was no correlation between age, glycated hemoglobin (HbA1c), height, weight, body mass index (BMI), and any corneal nerve fiber parameter in both sexes. In either sex, age, weight, height, BMI, and HbA1c did not affect the 0.05th quantile values of any corneal nerve parameter. Conclusions. This study establishes sex-adjusted reference values for corneal confocal microscopy measures in Chinese adults and provides a reference for clinical practice and research with this technique.http://dx.doi.org/10.1155/2022/4913031 |
| spellingShingle | Juan Cao Jingru Qu Bekzod Odilov Bin Lu Yuanpin Zhang Lili Li Yuan Zhang Qian Xiong Yu Hong Jianqiao Li Yunfeng Shen Xinguo Hou Corneal Nerve Parameter Reference Values for Chinese Adults Assessed by Corneal Confocal Microscopy Journal of Diabetes Research |
| title | Corneal Nerve Parameter Reference Values for Chinese Adults Assessed by Corneal Confocal Microscopy |
| title_full | Corneal Nerve Parameter Reference Values for Chinese Adults Assessed by Corneal Confocal Microscopy |
| title_fullStr | Corneal Nerve Parameter Reference Values for Chinese Adults Assessed by Corneal Confocal Microscopy |
| title_full_unstemmed | Corneal Nerve Parameter Reference Values for Chinese Adults Assessed by Corneal Confocal Microscopy |
| title_short | Corneal Nerve Parameter Reference Values for Chinese Adults Assessed by Corneal Confocal Microscopy |
| title_sort | corneal nerve parameter reference values for chinese adults assessed by corneal confocal microscopy |
| url | http://dx.doi.org/10.1155/2022/4913031 |
| work_keys_str_mv | AT juancao cornealnerveparameterreferencevaluesforchineseadultsassessedbycornealconfocalmicroscopy AT jingruqu cornealnerveparameterreferencevaluesforchineseadultsassessedbycornealconfocalmicroscopy AT bekzododilov cornealnerveparameterreferencevaluesforchineseadultsassessedbycornealconfocalmicroscopy AT binlu cornealnerveparameterreferencevaluesforchineseadultsassessedbycornealconfocalmicroscopy AT yuanpinzhang cornealnerveparameterreferencevaluesforchineseadultsassessedbycornealconfocalmicroscopy AT lilili cornealnerveparameterreferencevaluesforchineseadultsassessedbycornealconfocalmicroscopy AT yuanzhang cornealnerveparameterreferencevaluesforchineseadultsassessedbycornealconfocalmicroscopy AT qianxiong cornealnerveparameterreferencevaluesforchineseadultsassessedbycornealconfocalmicroscopy AT yuhong cornealnerveparameterreferencevaluesforchineseadultsassessedbycornealconfocalmicroscopy AT jianqiaoli cornealnerveparameterreferencevaluesforchineseadultsassessedbycornealconfocalmicroscopy AT yunfengshen cornealnerveparameterreferencevaluesforchineseadultsassessedbycornealconfocalmicroscopy AT xinguohou cornealnerveparameterreferencevaluesforchineseadultsassessedbycornealconfocalmicroscopy |