Effect of Topical Mometasone Furoate Cream (0.01 % w/w) on Blood Pressure, Blood Sugar and Blood Calcium Level
Background: Corticosteroids are commonly administered for skin diseases over short durations, typically ranging from a few days to a few weeks. The choice of corticosteroid is based on its potency, which is determined by the application site and the severity of the condition. The adverse e...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BKL Walawalkar Rural Medical College & Hospital
2024-10-01
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| Series: | Walawalkar International Medical Journal |
| Subjects: | |
| Online Access: | http://wimjournal.com |
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| Summary: | Background: Corticosteroids are commonly
administered for skin diseases over short durations,
typically ranging from a few days to a few weeks. The
choice of corticosteroid is based on its potency, which
is determined by the application site and the severity of
the condition. The adverse effects associated with
corticosteroid use are influenced by their strength, the
length of the treatment, and the extent of the affected
area. Material and Methods: This study examined the
impact of topical mometasone furoate on blood
pressure, blood sugar, and blood calcium levels after
seven days of application. Additionally, the study
assessed the relationship between the absorbed
concentration of corticosteroids and their effects on
blood pressure, blood sugar, blood calcium, and the
extent of the body surface area involved. Result: After
seven days of mometasone furoate use, no significant
changes were observed in blood pressure, blood sugar,
or blood calcium levels. The extent of the drugabsorbing surface area was found to be directly
proportional to the blood concentration of
corticosteroids. The effects on blood pressure, blood
sugar, and calcium levels were dependent on the
absorbed concentration, which, in turn, was influenced
by the drug-absorbing surface area. Conclusion: The
application of Mometasone Furoate to skin lesions does
not result in significant absorption into the bloodstream
at measurable levels and absorb concentration of
corticosteroids in the blood increases in proportion to
the extent of the area treated with topical steroids.
Mometasone Furoate did not cause any changes in
either systolic or diastolic blood pressure, blood sugar
or calcium levels after seven days.
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| ISSN: | 2395-0684 |