The Effect of Local Melatonin Application on Bone Fracture Healing in Rat Tibias
<i>Background and Objectives:</i> This study aimed to histologically evaluate the effects of local melatonin application at different doses on bone fracture healing. <i>Materials and Methods:</i> Thirty rats were divided into three groups, with ten rats in each group. In the...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/61/1/146 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588002103132160 |
|---|---|
| author | Murat Tanrisever Bahar Tekin Umit Koray Can Ozmen Istek Erhan Cahit Ozcan Ibrahim H. Ozercan Turker Gelic Serkan Dundar |
| author_facet | Murat Tanrisever Bahar Tekin Umit Koray Can Ozmen Istek Erhan Cahit Ozcan Ibrahim H. Ozercan Turker Gelic Serkan Dundar |
| author_sort | Murat Tanrisever |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> This study aimed to histologically evaluate the effects of local melatonin application at different doses on bone fracture healing. <i>Materials and Methods:</i> Thirty rats were divided into three groups, with ten rats in each group. In the control group (<i>n</i> = 10), a fracture line was created in the tibial bones, and fracture osteosynthesis was performed without any additional procedure. In the local melatonin dose 1 (MLT D-1) group (<i>n</i> = 10), a fracture line was created in the tibial bones, and 1.2 mg of lyophilized powder melatonin was applied locally before fracture osteosynthesis. In the local melatonin dose 2 (MLT D-2) group (<i>n</i> = 10), a fracture line was created in the tibial bones, and 3 mg of lyophilized powder melatonin was applied locally before fracture osteosynthesis. After a 12-week healing period, all subjects were sacrificed, and tibial bones were collected for histomorphometric analysis. <i>Results:</i> The percentage of bone formation was significantly higher in the MLT D-1 and MLT D-2 groups than in the control group. There was no statistically significant difference between the MLT D-1 and MLT D-2 groups. <i>Conclusions:</i> In conclusion, the study demonstrated that local melatonin application supports bone fracture by increasing bone formation, although different doses of melatonin did not lead to significant variations in fracture healing. |
| format | Article |
| id | doaj-art-84a40d3f10a740f3a2cc8ba9487847b8 |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-84a40d3f10a740f3a2cc8ba9487847b82025-01-24T13:40:50ZengMDPI AGMedicina1010-660X1648-91442025-01-0161114610.3390/medicina61010146The Effect of Local Melatonin Application on Bone Fracture Healing in Rat TibiasMurat Tanrisever0Bahar Tekin1Umit Koray Can2Ozmen Istek3Erhan Cahit Ozcan4Ibrahim H. Ozercan5Turker Gelic6Serkan Dundar7Department of Surgery, Faculty of Veterinary Medicine, Firat University, Elazig 23119, TürkiyeDepartment of Peridontology, Faculty of Dentistry, Firat University, Elazig 23119, TürkiyeTurkish Jockey Club Elazig Racecourse Horse Hospital, Elazig 23350, TürkiyeDepartment of Nursing, Faculty of Health Medicine, Mus Alparslan University, Mus 49250, TürkiyeDepartment of Esthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, Firat University, Elazig 23119, TürkiyeDepartment of Pathology, Faculty of Medicine, Firat University, Elazig 23119, TürkiyeDepartment of Surgery, Faculty of Veterinary Medicine, Firat University, Elazig 23119, TürkiyeDepartment of Peridontology, Faculty of Dentistry, Firat University, Elazig 23119, Türkiye<i>Background and Objectives:</i> This study aimed to histologically evaluate the effects of local melatonin application at different doses on bone fracture healing. <i>Materials and Methods:</i> Thirty rats were divided into three groups, with ten rats in each group. In the control group (<i>n</i> = 10), a fracture line was created in the tibial bones, and fracture osteosynthesis was performed without any additional procedure. In the local melatonin dose 1 (MLT D-1) group (<i>n</i> = 10), a fracture line was created in the tibial bones, and 1.2 mg of lyophilized powder melatonin was applied locally before fracture osteosynthesis. In the local melatonin dose 2 (MLT D-2) group (<i>n</i> = 10), a fracture line was created in the tibial bones, and 3 mg of lyophilized powder melatonin was applied locally before fracture osteosynthesis. After a 12-week healing period, all subjects were sacrificed, and tibial bones were collected for histomorphometric analysis. <i>Results:</i> The percentage of bone formation was significantly higher in the MLT D-1 and MLT D-2 groups than in the control group. There was no statistically significant difference between the MLT D-1 and MLT D-2 groups. <i>Conclusions:</i> In conclusion, the study demonstrated that local melatonin application supports bone fracture by increasing bone formation, although different doses of melatonin did not lead to significant variations in fracture healing.https://www.mdpi.com/1648-9144/61/1/146bone formationfracture healinglocal melatoninrat |
| spellingShingle | Murat Tanrisever Bahar Tekin Umit Koray Can Ozmen Istek Erhan Cahit Ozcan Ibrahim H. Ozercan Turker Gelic Serkan Dundar The Effect of Local Melatonin Application on Bone Fracture Healing in Rat Tibias Medicina bone formation fracture healing local melatonin rat |
| title | The Effect of Local Melatonin Application on Bone Fracture Healing in Rat Tibias |
| title_full | The Effect of Local Melatonin Application on Bone Fracture Healing in Rat Tibias |
| title_fullStr | The Effect of Local Melatonin Application on Bone Fracture Healing in Rat Tibias |
| title_full_unstemmed | The Effect of Local Melatonin Application on Bone Fracture Healing in Rat Tibias |
| title_short | The Effect of Local Melatonin Application on Bone Fracture Healing in Rat Tibias |
| title_sort | effect of local melatonin application on bone fracture healing in rat tibias |
| topic | bone formation fracture healing local melatonin rat |
| url | https://www.mdpi.com/1648-9144/61/1/146 |
| work_keys_str_mv | AT murattanrisever theeffectoflocalmelatoninapplicationonbonefracturehealinginrattibias AT bahartekin theeffectoflocalmelatoninapplicationonbonefracturehealinginrattibias AT umitkoraycan theeffectoflocalmelatoninapplicationonbonefracturehealinginrattibias AT ozmenistek theeffectoflocalmelatoninapplicationonbonefracturehealinginrattibias AT erhancahitozcan theeffectoflocalmelatoninapplicationonbonefracturehealinginrattibias AT ibrahimhozercan theeffectoflocalmelatoninapplicationonbonefracturehealinginrattibias AT turkergelic theeffectoflocalmelatoninapplicationonbonefracturehealinginrattibias AT serkandundar theeffectoflocalmelatoninapplicationonbonefracturehealinginrattibias AT murattanrisever effectoflocalmelatoninapplicationonbonefracturehealinginrattibias AT bahartekin effectoflocalmelatoninapplicationonbonefracturehealinginrattibias AT umitkoraycan effectoflocalmelatoninapplicationonbonefracturehealinginrattibias AT ozmenistek effectoflocalmelatoninapplicationonbonefracturehealinginrattibias AT erhancahitozcan effectoflocalmelatoninapplicationonbonefracturehealinginrattibias AT ibrahimhozercan effectoflocalmelatoninapplicationonbonefracturehealinginrattibias AT turkergelic effectoflocalmelatoninapplicationonbonefracturehealinginrattibias AT serkandundar effectoflocalmelatoninapplicationonbonefracturehealinginrattibias |