Aspartame and ischemic stroke: unraveling the molecular link through network toxicology and molecular docking analysis

Abstract Aspartame, a widely used artificial sweetener, remains controversial due to neurotoxic risks from its metabolites—phenylalanine, aspartic acid, and methanol. While epidemiological studies link artificial sweeteners to cerebrovascular disease, the molecular mechanisms connecting aspartame to...

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Bibliographic Details
Main Authors: Tianyu Zhang, Tao Wang, Kuangyang Yu, Changren huang, Kunyang Bao
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-08898-z
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