A Comprehensive Comparison of Clinical Presentation and Outcomes of Kidney Transplant Recipients with COVID-19 during Wave 1 versus Wave 2 at a Tertiary Care Center, India
Data comparing the clinical spectrum of COVID-19 in kidney transplant recipients (KTRs) during the first and second waves of the pandemic in India is limited. Our single-center retrospective study compared the clinical profile, mortality, and associated risk factors in KTRs with COVID-19 during the...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2022/9088393 |
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| author | Sanjiv Jasuja Gaurav Sagar Anupam Bahl Neharita Jasuja Rajesh Chawla Avdhesh Bansal Manjit. S. Kanwar Sudha Kansal Nikhil Modi Athar P. Ansari Viny Kantroo Purnima Dhar Chitra Chatterjee Nitin Ghonge Samir Tawakley Shalini Verma |
| author_facet | Sanjiv Jasuja Gaurav Sagar Anupam Bahl Neharita Jasuja Rajesh Chawla Avdhesh Bansal Manjit. S. Kanwar Sudha Kansal Nikhil Modi Athar P. Ansari Viny Kantroo Purnima Dhar Chitra Chatterjee Nitin Ghonge Samir Tawakley Shalini Verma |
| author_sort | Sanjiv Jasuja |
| collection | DOAJ |
| description | Data comparing the clinical spectrum of COVID-19 in kidney transplant recipients (KTRs) during the first and second waves of the pandemic in India is limited. Our single-center retrospective study compared the clinical profile, mortality, and associated risk factors in KTRs with COVID-19 during the 1st wave (1st February 2020 to 31st January 2021) and the second wave (1st March-31st August 2021). 156 KTRs with PCR confirmed SARS-CoV-2 infection treated at a tertiary care hospital in New Delhi during the 1st and the second waves were analyzed. The demographics and baseline transplant characteristics of the patients diagnosed during both waves were comparable. Patients in the second wave reported less frequent hospitalization, though the intensive care unit (ICU) and ventilator requirements were similar. Strategies to modify immunosuppressants such as discontinuation of antinucleoside drugs with or without change in calcineurin inhibitors and the use of steroids were similar during both waves. Overall patient mortality was 27.5%. The demographics and baseline characteristics of survivors and nonsurvivors were comparable. A higher percentage of nonsurvivors presented with breathing difficulty, low SpO2, and altered sensorium. Both wave risk factors for mortality included older age, severe disease, ICU/ventilator requirements, acute kidney injury (AKI) needing dialysis, Chest Computerized Tomographic (CT) scan abnormalities, and higher levels of inflammatory markers particularly D-dimer and interleukin-6 levels. Conclusions. KTRs in both COVID-19 waves had similar demographics and baseline characteristics, while fewer patients during the second wave required hospitalization. The D-dimer and IL-6 levels are directly correlated with mortality. |
| format | Article |
| id | doaj-art-8497dabeda81413e88fd609cfb92b9fe |
| institution | Kabale University |
| issn | 2090-2158 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-8497dabeda81413e88fd609cfb92b9fe2025-02-03T05:53:28ZengWileyInternational Journal of Nephrology2090-21582022-01-01202210.1155/2022/9088393A Comprehensive Comparison of Clinical Presentation and Outcomes of Kidney Transplant Recipients with COVID-19 during Wave 1 versus Wave 2 at a Tertiary Care Center, IndiaSanjiv Jasuja0Gaurav Sagar1Anupam Bahl2Neharita Jasuja3Rajesh Chawla4Avdhesh Bansal5Manjit. S. Kanwar6Sudha Kansal7Nikhil Modi8Athar P. Ansari9Viny Kantroo10Purnima Dhar11Chitra Chatterjee12Nitin Ghonge13Samir Tawakley14Shalini Verma15Indraprastha Apollo HospitalIndraprastha Apollo HospitalIndraprastha Apollo HospitalAVATAR FoundationIndraprastha Apollo HospitalIndraprastha Apollo HospitalIndraprastha Apollo HospitalIndraprastha Apollo HospitalIndraprastha Apollo HospitalIndraprastha Apollo HospitalIndraprastha Apollo HospitalIndraprastha Apollo HospitalIndraprastha Apollo HospitalIndraprastha Apollo HospitalApollo HospitalAVATAR FoundationData comparing the clinical spectrum of COVID-19 in kidney transplant recipients (KTRs) during the first and second waves of the pandemic in India is limited. Our single-center retrospective study compared the clinical profile, mortality, and associated risk factors in KTRs with COVID-19 during the 1st wave (1st February 2020 to 31st January 2021) and the second wave (1st March-31st August 2021). 156 KTRs with PCR confirmed SARS-CoV-2 infection treated at a tertiary care hospital in New Delhi during the 1st and the second waves were analyzed. The demographics and baseline transplant characteristics of the patients diagnosed during both waves were comparable. Patients in the second wave reported less frequent hospitalization, though the intensive care unit (ICU) and ventilator requirements were similar. Strategies to modify immunosuppressants such as discontinuation of antinucleoside drugs with or without change in calcineurin inhibitors and the use of steroids were similar during both waves. Overall patient mortality was 27.5%. The demographics and baseline characteristics of survivors and nonsurvivors were comparable. A higher percentage of nonsurvivors presented with breathing difficulty, low SpO2, and altered sensorium. Both wave risk factors for mortality included older age, severe disease, ICU/ventilator requirements, acute kidney injury (AKI) needing dialysis, Chest Computerized Tomographic (CT) scan abnormalities, and higher levels of inflammatory markers particularly D-dimer and interleukin-6 levels. Conclusions. KTRs in both COVID-19 waves had similar demographics and baseline characteristics, while fewer patients during the second wave required hospitalization. The D-dimer and IL-6 levels are directly correlated with mortality.http://dx.doi.org/10.1155/2022/9088393 |
| spellingShingle | Sanjiv Jasuja Gaurav Sagar Anupam Bahl Neharita Jasuja Rajesh Chawla Avdhesh Bansal Manjit. S. Kanwar Sudha Kansal Nikhil Modi Athar P. Ansari Viny Kantroo Purnima Dhar Chitra Chatterjee Nitin Ghonge Samir Tawakley Shalini Verma A Comprehensive Comparison of Clinical Presentation and Outcomes of Kidney Transplant Recipients with COVID-19 during Wave 1 versus Wave 2 at a Tertiary Care Center, India International Journal of Nephrology |
| title | A Comprehensive Comparison of Clinical Presentation and Outcomes of Kidney Transplant Recipients with COVID-19 during Wave 1 versus Wave 2 at a Tertiary Care Center, India |
| title_full | A Comprehensive Comparison of Clinical Presentation and Outcomes of Kidney Transplant Recipients with COVID-19 during Wave 1 versus Wave 2 at a Tertiary Care Center, India |
| title_fullStr | A Comprehensive Comparison of Clinical Presentation and Outcomes of Kidney Transplant Recipients with COVID-19 during Wave 1 versus Wave 2 at a Tertiary Care Center, India |
| title_full_unstemmed | A Comprehensive Comparison of Clinical Presentation and Outcomes of Kidney Transplant Recipients with COVID-19 during Wave 1 versus Wave 2 at a Tertiary Care Center, India |
| title_short | A Comprehensive Comparison of Clinical Presentation and Outcomes of Kidney Transplant Recipients with COVID-19 during Wave 1 versus Wave 2 at a Tertiary Care Center, India |
| title_sort | comprehensive comparison of clinical presentation and outcomes of kidney transplant recipients with covid 19 during wave 1 versus wave 2 at a tertiary care center india |
| url | http://dx.doi.org/10.1155/2022/9088393 |
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