Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment
Purpose. To determine if the abnormal macular microvasculature in hyperopic anisometropic amblyopia changes after occlusion therapy, and to discover if the macular microvasculature influences the efficacy of amblyopic treatment. Materials and Methods. Twenty-two children with hyperopic anisometropic...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2020/8879175 |
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| author | Wuhe Chen Frank Thorn Ruzhi Deng Xiaoman Li Jiangtao Lou Yingjie Wang Xinping Yu |
| author_facet | Wuhe Chen Frank Thorn Ruzhi Deng Xiaoman Li Jiangtao Lou Yingjie Wang Xinping Yu |
| author_sort | Wuhe Chen |
| collection | DOAJ |
| description | Purpose. To determine if the abnormal macular microvasculature in hyperopic anisometropic amblyopia changes after occlusion therapy, and to discover if the macular microvasculature influences the efficacy of amblyopic treatment. Materials and Methods. Twenty-two children with hyperopic anisometropic amblyopia (median, 8 years old) were enrolled along with 66 healthy controls of similar age and gender distribution. Best-corrected visual acuity (BCVA) was determined, and macular vessel density in the superficial and deep capillary plexuses (SCPs and DCPs, respectively) was measured by optical coherence tomography angiography before and after refractive correction and occlusion therapy. Changes in BCVA and macular SCP and DCP vessel density were measured after amblyopia treatment of 7.5 ± 4.4 months. Results. The amblyopic baseline BCVA, logMAR 0.42 ± 0.27, improved to logMAR 0.18 ± 0.18 in 14 patients (64%) after amblyopia treatment (P<0.001). In 8 patients (36%), there was no improvement in the BCVA. In amblyopic eyes with improved BCVA, the SCP density tended to increase in each parafoveal quadrant, while it tended to decrease in all quadrants of the fellow eyes. For patients in whom BCVA did not improve, the macular SCP vessel density tended to decrease in all quadrants of the amblyopic and fellow eyes. The posttreatment difference in SCP vessel density between amblyopic and fellow eyes was not significant. Multiple linear regression analysis showed that older age and greater foveal SCP vessel density were negatively correlated with BCVA improvement (P<0.018 and P<0.036, respectively). Conclusions. Macular vessel density tends to increase in anisometropic amblyopic eyes after successful treatment. Younger age and lower SCP macular density are predictive of a greater therapeutic effect of occlusion therapy. |
| format | Article |
| id | doaj-art-848d3f3228d54122adc65c1645fc19fc |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-848d3f3228d54122adc65c1645fc19fc2025-02-03T01:01:23ZengWileyJournal of Ophthalmology2090-004X2090-00582020-01-01202010.1155/2020/88791758879175Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful TreatmentWuhe Chen0Frank Thorn1Ruzhi Deng2Xiaoman Li3Jiangtao Lou4Yingjie Wang5Xinping Yu6School of Ophthalmology and Optometry, Eye Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, ChinaSchool of Ophthalmology and Optometry, Eye Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, ChinaSchool of Ophthalmology and Optometry, Eye Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, ChinaSchool of Ophthalmology and Optometry, Eye Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, ChinaSchool of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325000, Zhejiang, ChinaSchool of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325000, Zhejiang, ChinaSchool of Ophthalmology and Optometry, Eye Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, ChinaPurpose. To determine if the abnormal macular microvasculature in hyperopic anisometropic amblyopia changes after occlusion therapy, and to discover if the macular microvasculature influences the efficacy of amblyopic treatment. Materials and Methods. Twenty-two children with hyperopic anisometropic amblyopia (median, 8 years old) were enrolled along with 66 healthy controls of similar age and gender distribution. Best-corrected visual acuity (BCVA) was determined, and macular vessel density in the superficial and deep capillary plexuses (SCPs and DCPs, respectively) was measured by optical coherence tomography angiography before and after refractive correction and occlusion therapy. Changes in BCVA and macular SCP and DCP vessel density were measured after amblyopia treatment of 7.5 ± 4.4 months. Results. The amblyopic baseline BCVA, logMAR 0.42 ± 0.27, improved to logMAR 0.18 ± 0.18 in 14 patients (64%) after amblyopia treatment (P<0.001). In 8 patients (36%), there was no improvement in the BCVA. In amblyopic eyes with improved BCVA, the SCP density tended to increase in each parafoveal quadrant, while it tended to decrease in all quadrants of the fellow eyes. For patients in whom BCVA did not improve, the macular SCP vessel density tended to decrease in all quadrants of the amblyopic and fellow eyes. The posttreatment difference in SCP vessel density between amblyopic and fellow eyes was not significant. Multiple linear regression analysis showed that older age and greater foveal SCP vessel density were negatively correlated with BCVA improvement (P<0.018 and P<0.036, respectively). Conclusions. Macular vessel density tends to increase in anisometropic amblyopic eyes after successful treatment. Younger age and lower SCP macular density are predictive of a greater therapeutic effect of occlusion therapy.http://dx.doi.org/10.1155/2020/8879175 |
| spellingShingle | Wuhe Chen Frank Thorn Ruzhi Deng Xiaoman Li Jiangtao Lou Yingjie Wang Xinping Yu Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment Journal of Ophthalmology |
| title | Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment |
| title_full | Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment |
| title_fullStr | Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment |
| title_full_unstemmed | Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment |
| title_short | Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment |
| title_sort | macular microvasculature density changes in anisometropic amblyopic eyes after successful treatment |
| url | http://dx.doi.org/10.1155/2020/8879175 |
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