Construction of nomogram model based on contrast-enhanced ultrasound parameters to predict the degree of pathological differentiation of hepatocellular carcinoma
ObjectiveTo predict the degree of pathological differentiation of hepatocellular carcinoma (HCC) by quantitative analysis the correlation between the perfusion parameters of contrast-enhanced ultrasound (CEUS) and the pathological grades of HCC using VueBox® software.MethodsWe enrolled 189 patients...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1519703/full |
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| author | Shu-Min Lian Hong-Jing Cheng Hong-Jing Li Hui Wang |
| author_facet | Shu-Min Lian Hong-Jing Cheng Hong-Jing Li Hui Wang |
| author_sort | Shu-Min Lian |
| collection | DOAJ |
| description | ObjectiveTo predict the degree of pathological differentiation of hepatocellular carcinoma (HCC) by quantitative analysis the correlation between the perfusion parameters of contrast-enhanced ultrasound (CEUS) and the pathological grades of HCC using VueBox® software.MethodsWe enrolled 189 patients who underwent CEUS and liver biopsy at our hospital from July 2019 to September 2024 and were pathologically confirmed with primary HCC. The Edmondson-Steiner pathological classification system was used as the gold standard for dividing the patients into the low-grade and high-grade groups. The patients were randomly divided into training set and testing set in a ratio of 7:3, in which the parameters of the training set were analyzed by univariate analysis and then stepwise regression to construct the prediction model, and the diagnostic efficacy of the validation model was evaluated by discrimination, calibration, and clinical applicability.ResultsA total of 189 patients with primary hepatocellular carcinoma were enrolled, including 118 patients in the low-grade group and 71 patients in the high-grade group; they were randomly divided into training set of 128 patients and testing set of 61 patients. The prediction model was constructed by logistic regression in the training set, and the final model included three variables: mTTI, FT, and maximum diameter of a single lesion, resulting in the equation was Y=−2.360+1.674X1+1.019X2+0.753X3(2)+1.570X3(3).The area under the ROC curve (AUC) of the training set was 0.831, with a sensitivity of 82.0% and a specificity of 79.5%; the area under the ROC curve (AUC) of the testing set was 0.811, with a sensitivity of 81.0% and a specificity of 70.0%.ConclusionThe regression model constructed by combining multiple parameters can effectively improve the diagnostic performance of CEUS in predicting the pathological differentiation grade of HCC, thus providing a clinical basis and empirical support for the use of CEUS as a diagnostic imaging method for this disease. |
| format | Article |
| id | doaj-art-847ca6ae24da4f0ca64dbeb03d5da3b4 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-847ca6ae24da4f0ca64dbeb03d5da3b42025-01-27T05:14:31ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.15197031519703Construction of nomogram model based on contrast-enhanced ultrasound parameters to predict the degree of pathological differentiation of hepatocellular carcinomaShu-Min Lian0Hong-Jing Cheng1Hong-Jing Li2Hui Wang3Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Pathology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, Jilin, ChinaObjectiveTo predict the degree of pathological differentiation of hepatocellular carcinoma (HCC) by quantitative analysis the correlation between the perfusion parameters of contrast-enhanced ultrasound (CEUS) and the pathological grades of HCC using VueBox® software.MethodsWe enrolled 189 patients who underwent CEUS and liver biopsy at our hospital from July 2019 to September 2024 and were pathologically confirmed with primary HCC. The Edmondson-Steiner pathological classification system was used as the gold standard for dividing the patients into the low-grade and high-grade groups. The patients were randomly divided into training set and testing set in a ratio of 7:3, in which the parameters of the training set were analyzed by univariate analysis and then stepwise regression to construct the prediction model, and the diagnostic efficacy of the validation model was evaluated by discrimination, calibration, and clinical applicability.ResultsA total of 189 patients with primary hepatocellular carcinoma were enrolled, including 118 patients in the low-grade group and 71 patients in the high-grade group; they were randomly divided into training set of 128 patients and testing set of 61 patients. The prediction model was constructed by logistic regression in the training set, and the final model included three variables: mTTI, FT, and maximum diameter of a single lesion, resulting in the equation was Y=−2.360+1.674X1+1.019X2+0.753X3(2)+1.570X3(3).The area under the ROC curve (AUC) of the training set was 0.831, with a sensitivity of 82.0% and a specificity of 79.5%; the area under the ROC curve (AUC) of the testing set was 0.811, with a sensitivity of 81.0% and a specificity of 70.0%.ConclusionThe regression model constructed by combining multiple parameters can effectively improve the diagnostic performance of CEUS in predicting the pathological differentiation grade of HCC, thus providing a clinical basis and empirical support for the use of CEUS as a diagnostic imaging method for this disease.https://www.frontiersin.org/articles/10.3389/fonc.2025.1519703/fullnomogramcontrast-enhanced ultrasoundprimary hepatocellular carcinomaEdmondson-Steiner gradeVueBox® external perfusion software |
| spellingShingle | Shu-Min Lian Hong-Jing Cheng Hong-Jing Li Hui Wang Construction of nomogram model based on contrast-enhanced ultrasound parameters to predict the degree of pathological differentiation of hepatocellular carcinoma Frontiers in Oncology nomogram contrast-enhanced ultrasound primary hepatocellular carcinoma Edmondson-Steiner grade VueBox® external perfusion software |
| title | Construction of nomogram model based on contrast-enhanced ultrasound parameters to predict the degree of pathological differentiation of hepatocellular carcinoma |
| title_full | Construction of nomogram model based on contrast-enhanced ultrasound parameters to predict the degree of pathological differentiation of hepatocellular carcinoma |
| title_fullStr | Construction of nomogram model based on contrast-enhanced ultrasound parameters to predict the degree of pathological differentiation of hepatocellular carcinoma |
| title_full_unstemmed | Construction of nomogram model based on contrast-enhanced ultrasound parameters to predict the degree of pathological differentiation of hepatocellular carcinoma |
| title_short | Construction of nomogram model based on contrast-enhanced ultrasound parameters to predict the degree of pathological differentiation of hepatocellular carcinoma |
| title_sort | construction of nomogram model based on contrast enhanced ultrasound parameters to predict the degree of pathological differentiation of hepatocellular carcinoma |
| topic | nomogram contrast-enhanced ultrasound primary hepatocellular carcinoma Edmondson-Steiner grade VueBox® external perfusion software |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1519703/full |
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