Hyperglycemia in Streptozotocin-Induced Diabetes Leads to Persistent Inflammation and Tissue Damage Following Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1
This study investigated the heme oxygenase-1 (HO-1) and the endotoxin-induced uveitis (EIU) in diabetic streptozotocin (STZ)-hyperglycemic rats. STZ-hyperglycemic rats had impaired levels of the enzyme HO-1 within the ciliary bodies if compared with the nondiabetic rats. STZ-hyperglycemic rats also...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/60285 |
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| author | Settimio Rossi Michele D'Amico Annalisa Capuano Mary Romano Pasquale Petronella Clara Di Filippo |
| author_facet | Settimio Rossi Michele D'Amico Annalisa Capuano Mary Romano Pasquale Petronella Clara Di Filippo |
| author_sort | Settimio Rossi |
| collection | DOAJ |
| description | This study investigated the heme oxygenase-1 (HO-1) and the
endotoxin-induced uveitis (EIU) in diabetic streptozotocin
(STZ)-hyperglycemic rats. STZ-hyperglycemic rats had impaired
levels of the enzyme HO-1 within the ciliary bodies if
compared with the nondiabetic rats. STZ-hyperglycemic rats also
predisposed the eye to produce high levels of both the cytokines
IL-1β
and CXCL8. Subsequent EIU further and significantly
(P<.01)
increased the cytokines production, an effect partly
prevented by hemin treatment. Most importantly, hemin, an inducer
of heme oxygenase expression and activity, recovered the huge
number of infiltrated polymorphonuclear leukocytes PMN within the
ciliary bodies associated with STZ-hyperglycemic state and EIU
damage. Impairment of the stress-sensitive enzyme HO-1 in
STZ-hyperglycemic rats increases and prolongs the inflammatory
response to EIU. |
| format | Article |
| id | doaj-art-847b35652d72417481519426e68ccb62 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-847b35652d72417481519426e68ccb622025-02-03T05:49:57ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/6028560285Hyperglycemia in Streptozotocin-Induced Diabetes Leads to Persistent Inflammation and Tissue Damage Following Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1Settimio Rossi0Michele D'Amico1Annalisa Capuano2Mary Romano3Pasquale Petronella4Clara Di Filippo5Department of Experimental Medicine, Second University of Naples, Naples 80138, ItalyDepartment of Experimental Medicine, Second University of Naples, Naples 80138, ItalyDepartment of Experimental Medicine, Second University of Naples, Naples 80138, ItalyDepartment of Experimental Medicine, Second University of Naples, Naples 80138, ItalyDepartment of Experimental Medicine, Second University of Naples, Naples 80138, ItalyDepartment of Experimental Medicine, Second University of Naples, Naples 80138, ItalyThis study investigated the heme oxygenase-1 (HO-1) and the endotoxin-induced uveitis (EIU) in diabetic streptozotocin (STZ)-hyperglycemic rats. STZ-hyperglycemic rats had impaired levels of the enzyme HO-1 within the ciliary bodies if compared with the nondiabetic rats. STZ-hyperglycemic rats also predisposed the eye to produce high levels of both the cytokines IL-1β and CXCL8. Subsequent EIU further and significantly (P<.01) increased the cytokines production, an effect partly prevented by hemin treatment. Most importantly, hemin, an inducer of heme oxygenase expression and activity, recovered the huge number of infiltrated polymorphonuclear leukocytes PMN within the ciliary bodies associated with STZ-hyperglycemic state and EIU damage. Impairment of the stress-sensitive enzyme HO-1 in STZ-hyperglycemic rats increases and prolongs the inflammatory response to EIU.http://dx.doi.org/10.1155/MI/2006/60285 |
| spellingShingle | Settimio Rossi Michele D'Amico Annalisa Capuano Mary Romano Pasquale Petronella Clara Di Filippo Hyperglycemia in Streptozotocin-Induced Diabetes Leads to Persistent Inflammation and Tissue Damage Following Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1 Mediators of Inflammation |
| title | Hyperglycemia in Streptozotocin-Induced Diabetes
Leads to Persistent Inflammation and Tissue Damage Following
Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1 |
| title_full | Hyperglycemia in Streptozotocin-Induced Diabetes
Leads to Persistent Inflammation and Tissue Damage Following
Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1 |
| title_fullStr | Hyperglycemia in Streptozotocin-Induced Diabetes
Leads to Persistent Inflammation and Tissue Damage Following
Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1 |
| title_full_unstemmed | Hyperglycemia in Streptozotocin-Induced Diabetes
Leads to Persistent Inflammation and Tissue Damage Following
Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1 |
| title_short | Hyperglycemia in Streptozotocin-Induced Diabetes
Leads to Persistent Inflammation and Tissue Damage Following
Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1 |
| title_sort | hyperglycemia in streptozotocin induced diabetes leads to persistent inflammation and tissue damage following uveitis due to reduced levels of ciliary body heme oxygenase 1 |
| url | http://dx.doi.org/10.1155/MI/2006/60285 |
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