Hyperglycemia in Streptozotocin-Induced Diabetes Leads to Persistent Inflammation and Tissue Damage Following Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1
This study investigated the heme oxygenase-1 (HO-1) and the endotoxin-induced uveitis (EIU) in diabetic streptozotocin (STZ)-hyperglycemic rats. STZ-hyperglycemic rats had impaired levels of the enzyme HO-1 within the ciliary bodies if compared with the nondiabetic rats. STZ-hyperglycemic rats also...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/60285 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | This study investigated the heme oxygenase-1 (HO-1) and the
endotoxin-induced uveitis (EIU) in diabetic streptozotocin
(STZ)-hyperglycemic rats. STZ-hyperglycemic rats had impaired
levels of the enzyme HO-1 within the ciliary bodies if
compared with the nondiabetic rats. STZ-hyperglycemic rats also
predisposed the eye to produce high levels of both the cytokines
IL-1β
and CXCL8. Subsequent EIU further and significantly
(P<.01)
increased the cytokines production, an effect partly
prevented by hemin treatment. Most importantly, hemin, an inducer
of heme oxygenase expression and activity, recovered the huge
number of infiltrated polymorphonuclear leukocytes PMN within the
ciliary bodies associated with STZ-hyperglycemic state and EIU
damage. Impairment of the stress-sensitive enzyme HO-1 in
STZ-hyperglycemic rats increases and prolongs the inflammatory
response to EIU. |
|---|---|
| ISSN: | 0962-9351 1466-1861 |