Does viral circulation in slums have a global impact? The lesson learned from SARS-CoV-2 circulation in Complexo de favelas da Maré, Rio de Janeiro, Brazil
Because of growing inequalities, more than one-third of the worldwide population is expected to live in slums by 2050. Although slum dwellers are at increased risk of infectious diseases, this population may have been overlooked with respect to the sustainability of virus evolution. In this study, w...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1483895/full |
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| author | Monique Cristina dos Santos Monique Cristina dos Santos Natalia Fintelman-Rodrigues Natalia Fintelman-Rodrigues Aline de Paula Dias da Silva Aline de Paula Dias da Silva Rodolfo Leandro Nascimento Silva Victor Corrêa Seixas Amanda A. Batista-da-Silva Amanda A. Batista-da-Silva Marcelo Alves Ferreira Patrícia T. Bozza Fernando A. Bozza Fernando A. Bozza Fernando A. Bozza Thiago Moreno L. Souza Thiago Moreno L. Souza |
| author_facet | Monique Cristina dos Santos Monique Cristina dos Santos Natalia Fintelman-Rodrigues Natalia Fintelman-Rodrigues Aline de Paula Dias da Silva Aline de Paula Dias da Silva Rodolfo Leandro Nascimento Silva Victor Corrêa Seixas Amanda A. Batista-da-Silva Amanda A. Batista-da-Silva Marcelo Alves Ferreira Patrícia T. Bozza Fernando A. Bozza Fernando A. Bozza Fernando A. Bozza Thiago Moreno L. Souza Thiago Moreno L. Souza |
| author_sort | Monique Cristina dos Santos |
| collection | DOAJ |
| description | Because of growing inequalities, more than one-third of the worldwide population is expected to live in slums by 2050. Although slum dwellers are at increased risk of infectious diseases, this population may have been overlooked with respect to the sustainability of virus evolution. In this study, we aimed to analyze the genetic diversity and evolution of SARS-CoV-2 in the Complexo de Favelas da Maré slum, Rio de Janeiro, Brazil, and assess its impact on the global spread of the virus. We found that this slum harbored multiple strains of SARS-CoV-2, and its amplification and genetic diversity connected with the global circulation from 2020 to 2022. Thus, enhancing surveillance in slums could be important for future epidemic/pandemic preparedness by connecting virus genetic diversity in this region with its circulation at divergent locations. |
| format | Article |
| id | doaj-art-84727634585d475382707e1b8f3bc574 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-84727634585d475382707e1b8f3bc5742025-02-12T07:25:38ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-02-011610.3389/fmicb.2025.14838951483895Does viral circulation in slums have a global impact? The lesson learned from SARS-CoV-2 circulation in Complexo de favelas da Maré, Rio de Janeiro, BrazilMonique Cristina dos Santos0Monique Cristina dos Santos1Natalia Fintelman-Rodrigues2Natalia Fintelman-Rodrigues3Aline de Paula Dias da Silva4Aline de Paula Dias da Silva5Rodolfo Leandro Nascimento Silva6Victor Corrêa Seixas7Amanda A. Batista-da-Silva8Amanda A. Batista-da-Silva9Marcelo Alves Ferreira10Patrícia T. Bozza11Fernando A. Bozza12Fernando A. Bozza13Fernando A. Bozza14Thiago Moreno L. Souza15Thiago Moreno L. Souza16Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, BrazilNational Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, BrazilLaboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, BrazilNational Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, BrazilLaboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, BrazilNational Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, BrazilInstituto de Biologia, Universidade Federal Fluminense (UFF), Rio de Janeiro, BrazilInstituto de Biologia, Universidade Federal Fluminense (UFF), Rio de Janeiro, BrazilInstituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro, BrazilDepartment of Industrial Engineering, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, BrazilNational Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, BrazilLaboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, BrazilInstituto de Biologia, Universidade Federal Fluminense (UFF), Rio de Janeiro, BrazilD’Or Institute for Research and Education, Rio de Janeiro, BrazilTecgraf Institute, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, BrazilNational Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, BrazilBecause of growing inequalities, more than one-third of the worldwide population is expected to live in slums by 2050. Although slum dwellers are at increased risk of infectious diseases, this population may have been overlooked with respect to the sustainability of virus evolution. In this study, we aimed to analyze the genetic diversity and evolution of SARS-CoV-2 in the Complexo de Favelas da Maré slum, Rio de Janeiro, Brazil, and assess its impact on the global spread of the virus. We found that this slum harbored multiple strains of SARS-CoV-2, and its amplification and genetic diversity connected with the global circulation from 2020 to 2022. Thus, enhancing surveillance in slums could be important for future epidemic/pandemic preparedness by connecting virus genetic diversity in this region with its circulation at divergent locations.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1483895/fullCOVID-19SARS-CoV-2slumRio de JaneiroBrazil |
| spellingShingle | Monique Cristina dos Santos Monique Cristina dos Santos Natalia Fintelman-Rodrigues Natalia Fintelman-Rodrigues Aline de Paula Dias da Silva Aline de Paula Dias da Silva Rodolfo Leandro Nascimento Silva Victor Corrêa Seixas Amanda A. Batista-da-Silva Amanda A. Batista-da-Silva Marcelo Alves Ferreira Patrícia T. Bozza Fernando A. Bozza Fernando A. Bozza Fernando A. Bozza Thiago Moreno L. Souza Thiago Moreno L. Souza Does viral circulation in slums have a global impact? The lesson learned from SARS-CoV-2 circulation in Complexo de favelas da Maré, Rio de Janeiro, Brazil Frontiers in Microbiology COVID-19 SARS-CoV-2 slum Rio de Janeiro Brazil |
| title | Does viral circulation in slums have a global impact? The lesson learned from SARS-CoV-2 circulation in Complexo de favelas da Maré, Rio de Janeiro, Brazil |
| title_full | Does viral circulation in slums have a global impact? The lesson learned from SARS-CoV-2 circulation in Complexo de favelas da Maré, Rio de Janeiro, Brazil |
| title_fullStr | Does viral circulation in slums have a global impact? The lesson learned from SARS-CoV-2 circulation in Complexo de favelas da Maré, Rio de Janeiro, Brazil |
| title_full_unstemmed | Does viral circulation in slums have a global impact? The lesson learned from SARS-CoV-2 circulation in Complexo de favelas da Maré, Rio de Janeiro, Brazil |
| title_short | Does viral circulation in slums have a global impact? The lesson learned from SARS-CoV-2 circulation in Complexo de favelas da Maré, Rio de Janeiro, Brazil |
| title_sort | does viral circulation in slums have a global impact the lesson learned from sars cov 2 circulation in complexo de favelas da mare rio de janeiro brazil |
| topic | COVID-19 SARS-CoV-2 slum Rio de Janeiro Brazil |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1483895/full |
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