Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysis
IntroductionMajor depressive disorder with suicidal ideation (MDD/SI+) is characterized by high prevalence, high recurrence rate, high disability rate and low response rate. There is an urgent need for clarifying the pathogenesis and developing novel treatment methods.MethodsSubjects were recruited...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1486835/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591712779763712 |
|---|---|
| author | Yao Zhang Nan Mu Shun Qi Chuanzhu Sun Yang Rao Xinyi Yang Jianying Guo Yunfeng Mu |
| author_facet | Yao Zhang Nan Mu Shun Qi Chuanzhu Sun Yang Rao Xinyi Yang Jianying Guo Yunfeng Mu |
| author_sort | Yao Zhang |
| collection | DOAJ |
| description | IntroductionMajor depressive disorder with suicidal ideation (MDD/SI+) is characterized by high prevalence, high recurrence rate, high disability rate and low response rate. There is an urgent need for clarifying the pathogenesis and developing novel treatment methods.MethodsSubjects were recruited for the collection of Magnetic Resonance Imaging data and clinical scales. Individual target-transcranial magnetic stimulation (IT-TMS) using Stanford Neuromodulation Therapy over individualized left dorsolateral prefrontal cortex was performed to treat MDD/SI+ with the ethical approval (KY20212218-C-1). GRETNA software was used to analyze brain network characteristics according to graph theory.ResultsA total of 32 patients (aged 18-55) and 28 healthy controls (aged 20-51) had been recruited. Patients after IT-TMS treatment had significant reduction in suicidal ideation and depressive symptom. The functional network of all three groups conformed to small-world topology. There was a renormalization in topology structure after IT-TMS treatment. Decreased functional connectivity between right insula and left anterior cingulate gyrus correlated with improvement in Beck Scale for Suicide Ideation scores.DiscussionThe current study highlights that MDD/SI+ patients in this cohort showed abnormal brain network connections compared to healthy controls, and that IT-TMS may exert its treatment effects by reducing spontaneous hyper-connectivity in the salience network and insula. |
| format | Article |
| id | doaj-art-844fca07036f4160b13e1d09dd7695e9 |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-844fca07036f4160b13e1d09dd7695e92025-01-22T07:11:52ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-01-011610.3389/fpsyt.2025.14868351486835Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysisYao Zhang0Nan Mu1Shun Qi2Chuanzhu Sun3Yang Rao4Xinyi Yang5Jianying Guo6Yunfeng Mu7Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi, ChinaXijing Hospital, Air Force Medical University, Xi’an, Shaanxi, ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, The Key Laboratory of Neuro-informatics & Rehabilitation Engineering of Ministry of Civil Affairs, Xi’an Jiaotong University, Xi’an, ChinaShaanxi Brain Modulation and Scientific Research Center, Xi’an, Shaanxi, ChinaShaanxi Brain Modulation and Scientific Research Center, Xi’an, Shaanxi, ChinaXijing Hospital, Air Force Medical University, Xi’an, Shaanxi, ChinaXijing Hospital, Air Force Medical University, Xi’an, Shaanxi, ChinaDepartment of Gynecological Oncology, Shaanxi Provincial Cancer Hospital, Xi’an, ChinaIntroductionMajor depressive disorder with suicidal ideation (MDD/SI+) is characterized by high prevalence, high recurrence rate, high disability rate and low response rate. There is an urgent need for clarifying the pathogenesis and developing novel treatment methods.MethodsSubjects were recruited for the collection of Magnetic Resonance Imaging data and clinical scales. Individual target-transcranial magnetic stimulation (IT-TMS) using Stanford Neuromodulation Therapy over individualized left dorsolateral prefrontal cortex was performed to treat MDD/SI+ with the ethical approval (KY20212218-C-1). GRETNA software was used to analyze brain network characteristics according to graph theory.ResultsA total of 32 patients (aged 18-55) and 28 healthy controls (aged 20-51) had been recruited. Patients after IT-TMS treatment had significant reduction in suicidal ideation and depressive symptom. The functional network of all three groups conformed to small-world topology. There was a renormalization in topology structure after IT-TMS treatment. Decreased functional connectivity between right insula and left anterior cingulate gyrus correlated with improvement in Beck Scale for Suicide Ideation scores.DiscussionThe current study highlights that MDD/SI+ patients in this cohort showed abnormal brain network connections compared to healthy controls, and that IT-TMS may exert its treatment effects by reducing spontaneous hyper-connectivity in the salience network and insula.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1486835/fulldepressionsuicidal ideationtranscranial magnetic stimulationsmall-worldgraph-theory |
| spellingShingle | Yao Zhang Nan Mu Shun Qi Chuanzhu Sun Yang Rao Xinyi Yang Jianying Guo Yunfeng Mu Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysis Frontiers in Psychiatry depression suicidal ideation transcranial magnetic stimulation small-world graph-theory |
| title | Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysis |
| title_full | Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysis |
| title_fullStr | Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysis |
| title_full_unstemmed | Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysis |
| title_short | Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysis |
| title_sort | improved brain functional network in major depressive disorder with suicidal ideation after individual target transcranial magnetic stimulation treatment a graph theory analysis |
| topic | depression suicidal ideation transcranial magnetic stimulation small-world graph-theory |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1486835/full |
| work_keys_str_mv | AT yaozhang improvedbrainfunctionalnetworkinmajordepressivedisorderwithsuicidalideationafterindividualtargettranscranialmagneticstimulationtreatmentagraphtheoryanalysis AT nanmu improvedbrainfunctionalnetworkinmajordepressivedisorderwithsuicidalideationafterindividualtargettranscranialmagneticstimulationtreatmentagraphtheoryanalysis AT shunqi improvedbrainfunctionalnetworkinmajordepressivedisorderwithsuicidalideationafterindividualtargettranscranialmagneticstimulationtreatmentagraphtheoryanalysis AT chuanzhusun improvedbrainfunctionalnetworkinmajordepressivedisorderwithsuicidalideationafterindividualtargettranscranialmagneticstimulationtreatmentagraphtheoryanalysis AT yangrao improvedbrainfunctionalnetworkinmajordepressivedisorderwithsuicidalideationafterindividualtargettranscranialmagneticstimulationtreatmentagraphtheoryanalysis AT xinyiyang improvedbrainfunctionalnetworkinmajordepressivedisorderwithsuicidalideationafterindividualtargettranscranialmagneticstimulationtreatmentagraphtheoryanalysis AT jianyingguo improvedbrainfunctionalnetworkinmajordepressivedisorderwithsuicidalideationafterindividualtargettranscranialmagneticstimulationtreatmentagraphtheoryanalysis AT yunfengmu improvedbrainfunctionalnetworkinmajordepressivedisorderwithsuicidalideationafterindividualtargettranscranialmagneticstimulationtreatmentagraphtheoryanalysis |