Diabetic Kidney Disease: Pathophysiology and Therapeutic Targets
Diabetes is a worldwide epidemic that has led to a rise in diabetic kidney disease (DKD). Over the past two decades, there has been significant clarification of the various pathways implicated in the pathogenesis of DKD. Nonetheless, very little has changed in the way clinicians manage patients wit...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/697010 |
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| _version_ | 1832564549991006208 |
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| author | Stephanie Toth-Manikowski Mohamed G. Atta |
| author_facet | Stephanie Toth-Manikowski Mohamed G. Atta |
| author_sort | Stephanie Toth-Manikowski |
| collection | DOAJ |
| description | Diabetes is a worldwide epidemic that has led to a rise in diabetic kidney disease (DKD). Over the past two decades, there has been significant clarification of the various pathways implicated in the pathogenesis of DKD. Nonetheless, very little has changed in the way clinicians manage patients with this disorder. Indeed, treatment is primarily centered on controlling hyperglycemia and hypertension and inhibiting the renin-angiotensin system. The purpose of this review is to describe the current understanding of how the hemodynamic, metabolic, inflammatory, and alternative pathways are all entangled in pathogenesis of DKD and detail the various therapeutic targets that may one day play a role in quelling this epidemic. |
| format | Article |
| id | doaj-art-844aadfba5fa46bbb0bd8f9ca4c99047 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-844aadfba5fa46bbb0bd8f9ca4c990472025-02-03T01:10:43ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/697010697010Diabetic Kidney Disease: Pathophysiology and Therapeutic TargetsStephanie Toth-Manikowski0Mohamed G. Atta1Division of Nephrology, Johns Hopkins University, 1830 E. Monument Street, Suite 416, Baltimore, MD 21287, USADivision of Nephrology, Johns Hopkins University, 1830 E. Monument Street, Suite 416, Baltimore, MD 21287, USADiabetes is a worldwide epidemic that has led to a rise in diabetic kidney disease (DKD). Over the past two decades, there has been significant clarification of the various pathways implicated in the pathogenesis of DKD. Nonetheless, very little has changed in the way clinicians manage patients with this disorder. Indeed, treatment is primarily centered on controlling hyperglycemia and hypertension and inhibiting the renin-angiotensin system. The purpose of this review is to describe the current understanding of how the hemodynamic, metabolic, inflammatory, and alternative pathways are all entangled in pathogenesis of DKD and detail the various therapeutic targets that may one day play a role in quelling this epidemic.http://dx.doi.org/10.1155/2015/697010 |
| spellingShingle | Stephanie Toth-Manikowski Mohamed G. Atta Diabetic Kidney Disease: Pathophysiology and Therapeutic Targets Journal of Diabetes Research |
| title | Diabetic Kidney Disease: Pathophysiology and Therapeutic Targets |
| title_full | Diabetic Kidney Disease: Pathophysiology and Therapeutic Targets |
| title_fullStr | Diabetic Kidney Disease: Pathophysiology and Therapeutic Targets |
| title_full_unstemmed | Diabetic Kidney Disease: Pathophysiology and Therapeutic Targets |
| title_short | Diabetic Kidney Disease: Pathophysiology and Therapeutic Targets |
| title_sort | diabetic kidney disease pathophysiology and therapeutic targets |
| url | http://dx.doi.org/10.1155/2015/697010 |
| work_keys_str_mv | AT stephanietothmanikowski diabetickidneydiseasepathophysiologyandtherapeutictargets AT mohamedgatta diabetickidneydiseasepathophysiologyandtherapeutictargets |