Cellular aspects of immunity involved in the development of atherosclerosis
Atherosclerosis, previously regarded as a lipid storage disease, has now been classified as a chronic inflammatory disease. The hardening of arterial vessels characterizes atherosclerosis due to the accumulation of lipids in the arterial walls, eliciting an inflammatory response. The development of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1461535/full |
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| author | Khalil Khalaf Khalil Khalaf Khalil Khalaf Marc Chamieh Natalia Welc Chandpreet Singh Joanne Lynn Kaouk Aiden Kaouk Andrzej Mackiewicz Andrzej Mackiewicz Mariusz Kaczmarek Mariusz Kaczmarek Bartlomiej Perek |
| author_facet | Khalil Khalaf Khalil Khalaf Khalil Khalaf Marc Chamieh Natalia Welc Chandpreet Singh Joanne Lynn Kaouk Aiden Kaouk Andrzej Mackiewicz Andrzej Mackiewicz Mariusz Kaczmarek Mariusz Kaczmarek Bartlomiej Perek |
| author_sort | Khalil Khalaf |
| collection | DOAJ |
| description | Atherosclerosis, previously regarded as a lipid storage disease, has now been classified as a chronic inflammatory disease. The hardening of arterial vessels characterizes atherosclerosis due to the accumulation of lipids in the arterial walls, eliciting an inflammatory response. The development of atherosclerosis occurs in various stages and is facilitated by many clinical factors, such as hypertension, hyperlipidemia, and inflammatory status. A large arsenal of cells has been implicated in its development. This review will summarize the phases of atherosclerotic formation and all the cells involved in either promoting or inhibiting its development. |
| format | Article |
| id | doaj-art-844868f36e3a49a1838888001eff74cb |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-844868f36e3a49a1838888001eff74cb2025-01-29T05:21:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.14615351461535Cellular aspects of immunity involved in the development of atherosclerosisKhalil Khalaf0Khalil Khalaf1Khalil Khalaf2Marc Chamieh3Natalia Welc4Chandpreet Singh5Joanne Lynn Kaouk6Aiden Kaouk7Andrzej Mackiewicz8Andrzej Mackiewicz9Mariusz Kaczmarek10Mariusz Kaczmarek11Bartlomiej Perek12Doctoral School, Poznan University of Medical Sciences, Poznan, PolandDepartment of Cancer Immunology, Poznan University of Medical Sciences, Poznań, PolandDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, PolandDepartment of Spine Disorders and Pediatric Orthopedics, Poznan University of Medical Sciences, Poznań, PolandDepartment of Dermatology, Poznan University of Medical Sciences, Poznan, PolandDepartment of Internal Medicine, University of California, Los Angeles (UCLA) - Kern Medical Center, Bakersfield, CA, United StatesDepartment of Science, Louisiana State University, Lousiana, LA, United StatesDepartment of Natural Sciences, The University of Texas at Austin, Texas, TX, United StatesDepartment of Cancer Immunology, Poznan University of Medical Sciences, Poznań, PolandDepartment of Cancer Diagnostics and Immunology, Greater Poland Cancer Center, Poznań, PolandDepartment of Cancer Immunology, Poznan University of Medical Sciences, Poznań, PolandDepartment of Cancer Diagnostics and Immunology, Greater Poland Cancer Center, Poznań, PolandDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, PolandAtherosclerosis, previously regarded as a lipid storage disease, has now been classified as a chronic inflammatory disease. The hardening of arterial vessels characterizes atherosclerosis due to the accumulation of lipids in the arterial walls, eliciting an inflammatory response. The development of atherosclerosis occurs in various stages and is facilitated by many clinical factors, such as hypertension, hyperlipidemia, and inflammatory status. A large arsenal of cells has been implicated in its development. This review will summarize the phases of atherosclerotic formation and all the cells involved in either promoting or inhibiting its development.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1461535/fullcardiovascular diseaseinterferonmonocyteslymphocytesinterleukinatherosclerosis |
| spellingShingle | Khalil Khalaf Khalil Khalaf Khalil Khalaf Marc Chamieh Natalia Welc Chandpreet Singh Joanne Lynn Kaouk Aiden Kaouk Andrzej Mackiewicz Andrzej Mackiewicz Mariusz Kaczmarek Mariusz Kaczmarek Bartlomiej Perek Cellular aspects of immunity involved in the development of atherosclerosis Frontiers in Immunology cardiovascular disease interferon monocytes lymphocytes interleukin atherosclerosis |
| title | Cellular aspects of immunity involved in the development of atherosclerosis |
| title_full | Cellular aspects of immunity involved in the development of atherosclerosis |
| title_fullStr | Cellular aspects of immunity involved in the development of atherosclerosis |
| title_full_unstemmed | Cellular aspects of immunity involved in the development of atherosclerosis |
| title_short | Cellular aspects of immunity involved in the development of atherosclerosis |
| title_sort | cellular aspects of immunity involved in the development of atherosclerosis |
| topic | cardiovascular disease interferon monocytes lymphocytes interleukin atherosclerosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1461535/full |
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