Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound
Fibroblasts are the essential cell type of skin, highly involved in the wound regeneration process. In this study, we sought to screen out the novel genes which act important roles in diabetic fibroblasts through bioinformatic methods. A total of 811 and 490 differentially expressed genes (DEGs) bet...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/7619610 |
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| _version_ | 1832560744301854720 |
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| author | Weirong Zhu Qin Fang Zhao Liu Qiming Chen |
| author_facet | Weirong Zhu Qin Fang Zhao Liu Qiming Chen |
| author_sort | Weirong Zhu |
| collection | DOAJ |
| description | Fibroblasts are the essential cell type of skin, highly involved in the wound regeneration process. In this study, we sought to screen out the novel genes which act important roles in diabetic fibroblasts through bioinformatic methods. A total of 811 and 490 differentially expressed genes (DEGs) between diabetic and normal fibroblasts were screened out in GSE49566 and GSE78891, respectively. Furthermore, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways involved in type 2 diabetes were retrieved from miRWalk. Consequently, the integrated bioinformatic analyses revealed the shared KEGG pathways between DEG-identified and diabetes-related pathways were functionally enriched in the MAPK signaling pathway, and the MAPKAPK3, HSPA2, TGFBR1, and p53 signaling pathways were involved. Finally, ETV4 and NPE2 were identified as the targeted transcript factors of MAPKAPK3, HSPA2, and TGFBR1. Our findings may throw novel sight in elucidating the molecular mechanisms of fibroblast pathologies in patients with diabetic wounds and targeting new factors to advance diabetic wound treatment in clinic. |
| format | Article |
| id | doaj-art-84410d0b088b4889a00cfff4df43ed03 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-84410d0b088b4889a00cfff4df43ed032025-02-03T01:26:55ZengWileyJournal of Diabetes Research2314-67532021-01-01202110.1155/2021/7619610Novel Genes Potentially Involved in Fibroblasts of Diabetic WoundWeirong Zhu0Qin Fang1Zhao Liu2Qiming Chen3Department of Hand and Foot SurgeryDepartment of Breast SurgeryDepartment of Hand and Foot SurgeryDepartment of Hand and Foot SurgeryFibroblasts are the essential cell type of skin, highly involved in the wound regeneration process. In this study, we sought to screen out the novel genes which act important roles in diabetic fibroblasts through bioinformatic methods. A total of 811 and 490 differentially expressed genes (DEGs) between diabetic and normal fibroblasts were screened out in GSE49566 and GSE78891, respectively. Furthermore, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways involved in type 2 diabetes were retrieved from miRWalk. Consequently, the integrated bioinformatic analyses revealed the shared KEGG pathways between DEG-identified and diabetes-related pathways were functionally enriched in the MAPK signaling pathway, and the MAPKAPK3, HSPA2, TGFBR1, and p53 signaling pathways were involved. Finally, ETV4 and NPE2 were identified as the targeted transcript factors of MAPKAPK3, HSPA2, and TGFBR1. Our findings may throw novel sight in elucidating the molecular mechanisms of fibroblast pathologies in patients with diabetic wounds and targeting new factors to advance diabetic wound treatment in clinic.http://dx.doi.org/10.1155/2021/7619610 |
| spellingShingle | Weirong Zhu Qin Fang Zhao Liu Qiming Chen Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound Journal of Diabetes Research |
| title | Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound |
| title_full | Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound |
| title_fullStr | Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound |
| title_full_unstemmed | Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound |
| title_short | Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound |
| title_sort | novel genes potentially involved in fibroblasts of diabetic wound |
| url | http://dx.doi.org/10.1155/2021/7619610 |
| work_keys_str_mv | AT weirongzhu novelgenespotentiallyinvolvedinfibroblastsofdiabeticwound AT qinfang novelgenespotentiallyinvolvedinfibroblastsofdiabeticwound AT zhaoliu novelgenespotentiallyinvolvedinfibroblastsofdiabeticwound AT qimingchen novelgenespotentiallyinvolvedinfibroblastsofdiabeticwound |