Cardiomyopathy Classification: Ongoing Debate in the Genomics Era
Cardiomyopathies represent a group of diseases of the myocardium of the heart and include diseases both primarily of the cardiac muscle and systemic diseases leading to adverse effects on the heart muscle size, shape, and function. Traditionally cardiomyopathies were defined according to phenotypica...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/796926 |
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| author | Charles McCartan Robert Mason S. R. Jayasinghe Lyn R. Griffiths |
| author_facet | Charles McCartan Robert Mason S. R. Jayasinghe Lyn R. Griffiths |
| author_sort | Charles McCartan |
| collection | DOAJ |
| description | Cardiomyopathies represent a group of diseases of the myocardium of the heart and include diseases both primarily of the cardiac muscle and systemic diseases leading to adverse effects on the heart muscle size, shape, and function. Traditionally cardiomyopathies were defined according to phenotypical appearance. Now, as our understanding of the pathophysiology of the different entities classified under each of the different phenotypes improves and our knowledge of the molecular and genetic basis for these entities progresses, the traditional classifications seem oversimplistic and do not reflect current understanding of this myriad of diseases and disease processes. Although our knowledge of the exact basis of many of the disease processes of cardiomyopathies is still in its infancy, it is important to have a classification system that has the ability to incorporate the coming tide of molecular and genetic information. This paper discusses how the traditional classification of cardiomyopathies based on morphology has evolved due to rapid advances in our understanding of the genetic and molecular basis for many of these clinical entities. |
| format | Article |
| id | doaj-art-842b82343afa43aa883f816883de4d31 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-842b82343afa43aa883f816883de4d312025-02-03T01:21:00ZengWileyBiochemistry Research International2090-22472090-22552012-01-01201210.1155/2012/796926796926Cardiomyopathy Classification: Ongoing Debate in the Genomics EraCharles McCartan0Robert Mason1S. R. Jayasinghe2Lyn R. Griffiths3Genomics Research Centre, Griffith Health Institute, Griffith University, Parklands Drive, Southport, QLD 4222, AustraliaDepartment of Cardiology, Gold Coast Hospital, Southport Campus, Nerang Street, Southport, QLD 4218, AustraliaDepartment of Cardiology, Gold Coast Hospital, Southport Campus, Nerang Street, Southport, QLD 4218, AustraliaGenomics Research Centre, Griffith Health Institute, Griffith University, Parklands Drive, Southport, QLD 4222, AustraliaCardiomyopathies represent a group of diseases of the myocardium of the heart and include diseases both primarily of the cardiac muscle and systemic diseases leading to adverse effects on the heart muscle size, shape, and function. Traditionally cardiomyopathies were defined according to phenotypical appearance. Now, as our understanding of the pathophysiology of the different entities classified under each of the different phenotypes improves and our knowledge of the molecular and genetic basis for these entities progresses, the traditional classifications seem oversimplistic and do not reflect current understanding of this myriad of diseases and disease processes. Although our knowledge of the exact basis of many of the disease processes of cardiomyopathies is still in its infancy, it is important to have a classification system that has the ability to incorporate the coming tide of molecular and genetic information. This paper discusses how the traditional classification of cardiomyopathies based on morphology has evolved due to rapid advances in our understanding of the genetic and molecular basis for many of these clinical entities.http://dx.doi.org/10.1155/2012/796926 |
| spellingShingle | Charles McCartan Robert Mason S. R. Jayasinghe Lyn R. Griffiths Cardiomyopathy Classification: Ongoing Debate in the Genomics Era Biochemistry Research International |
| title | Cardiomyopathy Classification: Ongoing Debate in the Genomics Era |
| title_full | Cardiomyopathy Classification: Ongoing Debate in the Genomics Era |
| title_fullStr | Cardiomyopathy Classification: Ongoing Debate in the Genomics Era |
| title_full_unstemmed | Cardiomyopathy Classification: Ongoing Debate in the Genomics Era |
| title_short | Cardiomyopathy Classification: Ongoing Debate in the Genomics Era |
| title_sort | cardiomyopathy classification ongoing debate in the genomics era |
| url | http://dx.doi.org/10.1155/2012/796926 |
| work_keys_str_mv | AT charlesmccartan cardiomyopathyclassificationongoingdebateinthegenomicsera AT robertmason cardiomyopathyclassificationongoingdebateinthegenomicsera AT srjayasinghe cardiomyopathyclassificationongoingdebateinthegenomicsera AT lynrgriffiths cardiomyopathyclassificationongoingdebateinthegenomicsera |