Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection
The Sjögren syndrome has been diagnosed in patients with HTLV-1 associated myelopathy and dry mouth and dry eyes are documented in HTLV-1 carriers. However the diagnosis of Sjögren syndrome in these subjects has been contested. In this cross-sectional study, we evaluated the role of immunological fa...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/8402059 |
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| author | Clara Mônica Lima Silvane Santos Adriana Dourado Natália B. Carvalho Valéria Bittencourt Marcus Miranda Lessa Isadora Siqueira Edgar M. Carvalho |
| author_facet | Clara Mônica Lima Silvane Santos Adriana Dourado Natália B. Carvalho Valéria Bittencourt Marcus Miranda Lessa Isadora Siqueira Edgar M. Carvalho |
| author_sort | Clara Mônica Lima |
| collection | DOAJ |
| description | The Sjögren syndrome has been diagnosed in patients with HTLV-1 associated myelopathy and dry mouth and dry eyes are documented in HTLV-1 carriers. However the diagnosis of Sjögren syndrome in these subjects has been contested. In this cross-sectional study, we evaluated the role of immunological factors and proviral load, in sicca syndrome associated with HTLV-1 in patients without myelopathy. Subjects were recruited in the HTLV-1 Clinic, from 2009 to 2011. The proviral load and cytokine levels (IFN-γ, TNF-α, IL-5, and IL-10) were obtained from a database containing the values presented by the subjects at admission in the clinic. Of the 272 participants, 59 (21.7%) had sicca syndrome and in all of them anti-Sjögren syndrome related antigen A (SSA) and antigen B (SSB) were negatives. The production of TNF-α and IFN-γ was higher in the group with sicca syndrome (P<0.05) than in HTLV-1 infected subjects without sicca syndrome. Our data indicates that patients with sicca syndrome associated with HTLV-1 do not have Sjögren syndrome. However the increased production of TNF-α and IFN-γ in this group of patients may contribute to the pathogenesis of sicca syndrome associated with HTLV-1. |
| format | Article |
| id | doaj-art-841cd8f607524bb998bea790d38a041f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-841cd8f607524bb998bea790d38a041f2025-02-03T01:32:43ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/84020598402059Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 InfectionClara Mônica Lima0Silvane Santos1Adriana Dourado2Natália B. Carvalho3Valéria Bittencourt4Marcus Miranda Lessa5Isadora Siqueira6Edgar M. Carvalho7Postgraduate Program in Health Sciences, Federal University of Bahia School of Medicine, 40025-010 Salvador, BA, BrazilImmunology Service, Professor Edgard Santos University Hospital, Federal University of Bahia, 40110-060 Salvador, BA, BrazilImmunology Service, Professor Edgard Santos University Hospital, Federal University of Bahia, 40110-060 Salvador, BA, BrazilImmunology Service, Professor Edgard Santos University Hospital, Federal University of Bahia, 40110-060 Salvador, BA, BrazilImmunology Service, Professor Edgard Santos University Hospital, Federal University of Bahia, 40110-060 Salvador, BA, BrazilPostgraduate Program in Health Sciences, Federal University of Bahia School of Medicine, 40025-010 Salvador, BA, BrazilImmunology Service, Professor Edgard Santos University Hospital, Federal University of Bahia, 40110-060 Salvador, BA, BrazilPostgraduate Program in Health Sciences, Federal University of Bahia School of Medicine, 40025-010 Salvador, BA, BrazilThe Sjögren syndrome has been diagnosed in patients with HTLV-1 associated myelopathy and dry mouth and dry eyes are documented in HTLV-1 carriers. However the diagnosis of Sjögren syndrome in these subjects has been contested. In this cross-sectional study, we evaluated the role of immunological factors and proviral load, in sicca syndrome associated with HTLV-1 in patients without myelopathy. Subjects were recruited in the HTLV-1 Clinic, from 2009 to 2011. The proviral load and cytokine levels (IFN-γ, TNF-α, IL-5, and IL-10) were obtained from a database containing the values presented by the subjects at admission in the clinic. Of the 272 participants, 59 (21.7%) had sicca syndrome and in all of them anti-Sjögren syndrome related antigen A (SSA) and antigen B (SSB) were negatives. The production of TNF-α and IFN-γ was higher in the group with sicca syndrome (P<0.05) than in HTLV-1 infected subjects without sicca syndrome. Our data indicates that patients with sicca syndrome associated with HTLV-1 do not have Sjögren syndrome. However the increased production of TNF-α and IFN-γ in this group of patients may contribute to the pathogenesis of sicca syndrome associated with HTLV-1.http://dx.doi.org/10.1155/2016/8402059 |
| spellingShingle | Clara Mônica Lima Silvane Santos Adriana Dourado Natália B. Carvalho Valéria Bittencourt Marcus Miranda Lessa Isadora Siqueira Edgar M. Carvalho Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection Journal of Immunology Research |
| title | Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection |
| title_full | Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection |
| title_fullStr | Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection |
| title_full_unstemmed | Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection |
| title_short | Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection |
| title_sort | association of sicca syndrome with proviral load and proinflammatory cytokines in htlv 1 infection |
| url | http://dx.doi.org/10.1155/2016/8402059 |
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