Absence of the interthalamic adhesion (ITA) as a neuroanatomical association or risk factor for neuropsychiatric disorders: A systemic review and meta-analysis
Background: This study aimed to provide an up-to-date account of the frequency of “the absence of interthalamic adhesion (AITA) as a risk factor or association” in healthy subjects and neuropsychiatric patients. Owing to the increased interest in the contribution of ITA to neurological function in p...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-10-01
|
| Series: | Indian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_744_22 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586139558477824 |
|---|---|
| author | Adil Asghar Ravi K. Narayan Pankaj Kumar Kumar S. Ravi R. Shane Tubbs Apurba Patra Shagufta Naaz |
| author_facet | Adil Asghar Ravi K. Narayan Pankaj Kumar Kumar S. Ravi R. Shane Tubbs Apurba Patra Shagufta Naaz |
| author_sort | Adil Asghar |
| collection | DOAJ |
| description | Background:
This study aimed to provide an up-to-date account of the frequency of “the absence of interthalamic adhesion (AITA) as a risk factor or association” in healthy subjects and neuropsychiatric patients. Owing to the increased interest in the contribution of ITA to neurological function in previous literature, a meta-analysis of its frequency and sex dependency is required.
Aim:
This study aimed to study whether the AITA is associated with neuropsychiatric disorders.
Settings and Design:
This study is a meta-analysis and systemic review.
Methods and Material:
Literature searches were conducted in PubMed, Web of Science, and Google Scholar using the keywords “interthalamic adhesion,” “massa intermedia,” “adhesio interthalamica,” and “adhesion” along with the Boolean operators (OR, AND, and NOT). Three reviewers independently assessed the abstracts and full texts for validation based on the inclusion criteria. The meta-analysis was performed using Microsoft Excel 2019 for descriptive studies and RevMan 5.2 for comparative studies.
Results:
The incidence of absent ITA was 15.3% in healthy subjects and 28.76% in neuropsychiatric subjects. The relative probability of AITA was 2.30 [95% confidence interval (CI), 1.96–2.70] in neuropsychiatric illness. Healthy men were 1.91 times more likely, and men with neuropsychiatric disorders were 1.82 times more likely to have absent ITA than women.
Conclusions and Relevance:
In this study, a consistent association of AITA with psychiatric disorders was observed, rendering the condition to be treated as an associated risk factor affecting the function of the habenula nuclear complex via the stria medullaris thalami. A cohort or longitudinal study is needed to compare the incidence of psychiatric disorders in individuals with or without ITA and to calculate the attributed risk. |
| format | Article |
| id | doaj-art-841cadebd2ac48a880a7396fc09691bd |
| institution | Kabale University |
| issn | 0019-5545 1998-3794 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Psychiatry |
| spelling | doaj-art-841cadebd2ac48a880a7396fc09691bd2025-01-26T08:53:44ZengWolters Kluwer Medknow PublicationsIndian Journal of Psychiatry0019-55451998-37942023-10-01651098599410.4103/indianjpsychiatry.indianjpsychiatry_744_22Absence of the interthalamic adhesion (ITA) as a neuroanatomical association or risk factor for neuropsychiatric disorders: A systemic review and meta-analysisAdil AsgharRavi K. NarayanPankaj KumarKumar S. RaviR. Shane TubbsApurba PatraShagufta NaazBackground: This study aimed to provide an up-to-date account of the frequency of “the absence of interthalamic adhesion (AITA) as a risk factor or association” in healthy subjects and neuropsychiatric patients. Owing to the increased interest in the contribution of ITA to neurological function in previous literature, a meta-analysis of its frequency and sex dependency is required. Aim: This study aimed to study whether the AITA is associated with neuropsychiatric disorders. Settings and Design: This study is a meta-analysis and systemic review. Methods and Material: Literature searches were conducted in PubMed, Web of Science, and Google Scholar using the keywords “interthalamic adhesion,” “massa intermedia,” “adhesio interthalamica,” and “adhesion” along with the Boolean operators (OR, AND, and NOT). Three reviewers independently assessed the abstracts and full texts for validation based on the inclusion criteria. The meta-analysis was performed using Microsoft Excel 2019 for descriptive studies and RevMan 5.2 for comparative studies. Results: The incidence of absent ITA was 15.3% in healthy subjects and 28.76% in neuropsychiatric subjects. The relative probability of AITA was 2.30 [95% confidence interval (CI), 1.96–2.70] in neuropsychiatric illness. Healthy men were 1.91 times more likely, and men with neuropsychiatric disorders were 1.82 times more likely to have absent ITA than women. Conclusions and Relevance: In this study, a consistent association of AITA with psychiatric disorders was observed, rendering the condition to be treated as an associated risk factor affecting the function of the habenula nuclear complex via the stria medullaris thalami. A cohort or longitudinal study is needed to compare the incidence of psychiatric disorders in individuals with or without ITA and to calculate the attributed risk.https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_744_22adhesio interthalamicaanatomyinterthalamic adhesionmeta-analysismri studiesneuropsychiatric disorderspostmortem studies |
| spellingShingle | Adil Asghar Ravi K. Narayan Pankaj Kumar Kumar S. Ravi R. Shane Tubbs Apurba Patra Shagufta Naaz Absence of the interthalamic adhesion (ITA) as a neuroanatomical association or risk factor for neuropsychiatric disorders: A systemic review and meta-analysis Indian Journal of Psychiatry adhesio interthalamica anatomy interthalamic adhesion meta-analysis mri studies neuropsychiatric disorders postmortem studies |
| title | Absence of the interthalamic adhesion (ITA) as a neuroanatomical association or risk factor for neuropsychiatric disorders: A systemic review and meta-analysis |
| title_full | Absence of the interthalamic adhesion (ITA) as a neuroanatomical association or risk factor for neuropsychiatric disorders: A systemic review and meta-analysis |
| title_fullStr | Absence of the interthalamic adhesion (ITA) as a neuroanatomical association or risk factor for neuropsychiatric disorders: A systemic review and meta-analysis |
| title_full_unstemmed | Absence of the interthalamic adhesion (ITA) as a neuroanatomical association or risk factor for neuropsychiatric disorders: A systemic review and meta-analysis |
| title_short | Absence of the interthalamic adhesion (ITA) as a neuroanatomical association or risk factor for neuropsychiatric disorders: A systemic review and meta-analysis |
| title_sort | absence of the interthalamic adhesion ita as a neuroanatomical association or risk factor for neuropsychiatric disorders a systemic review and meta analysis |
| topic | adhesio interthalamica anatomy interthalamic adhesion meta-analysis mri studies neuropsychiatric disorders postmortem studies |
| url | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_744_22 |
| work_keys_str_mv | AT adilasghar absenceoftheinterthalamicadhesionitaasaneuroanatomicalassociationorriskfactorforneuropsychiatricdisordersasystemicreviewandmetaanalysis AT raviknarayan absenceoftheinterthalamicadhesionitaasaneuroanatomicalassociationorriskfactorforneuropsychiatricdisordersasystemicreviewandmetaanalysis AT pankajkumar absenceoftheinterthalamicadhesionitaasaneuroanatomicalassociationorriskfactorforneuropsychiatricdisordersasystemicreviewandmetaanalysis AT kumarsravi absenceoftheinterthalamicadhesionitaasaneuroanatomicalassociationorriskfactorforneuropsychiatricdisordersasystemicreviewandmetaanalysis AT rshanetubbs absenceoftheinterthalamicadhesionitaasaneuroanatomicalassociationorriskfactorforneuropsychiatricdisordersasystemicreviewandmetaanalysis AT apurbapatra absenceoftheinterthalamicadhesionitaasaneuroanatomicalassociationorriskfactorforneuropsychiatricdisordersasystemicreviewandmetaanalysis AT shaguftanaaz absenceoftheinterthalamicadhesionitaasaneuroanatomicalassociationorriskfactorforneuropsychiatricdisordersasystemicreviewandmetaanalysis |