Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation: Implications in Cancer and Neurodegeneration
S-nitrosylation is a posttranslational modification of cysteine residues that has been frequently indicated as potential molecular mechanism governing cell response upon redox unbalance downstream of nitric oxide (over)production. In the last years, increased levels of S-nitrosothiols (SNOs) have be...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/361872 |
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| _version_ | 1832549525196111872 |
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| author | Giuseppina Di Giacomo Salvatore Rizza Costanza Montagna Giuseppe Filomeni |
| author_facet | Giuseppina Di Giacomo Salvatore Rizza Costanza Montagna Giuseppe Filomeni |
| author_sort | Giuseppina Di Giacomo |
| collection | DOAJ |
| description | S-nitrosylation is a posttranslational modification of cysteine residues that has been frequently indicated as potential molecular mechanism governing cell response upon redox unbalance downstream of nitric oxide (over)production. In the last years, increased levels of S-nitrosothiols (SNOs) have been tightly associated with the onset of nitroxidative stress-based pathologies (e.g., cancer and neurodegeneration), conditions in which alterations of mitochondrial homeostasis and activation of cellular processes dependent on it have been reported as well. In this paper we aim at summarizing the current knowledge of mitochondria-related proteins undergoing S-nitrosylation and how this redox modification might impact on mitochondrial functions, whose impairment has been correlated to tumorigenesis and neuronal cell death. In particular, emphasis will be given to the possible, but still neglected implication of denitrosylation reactions in the modulation of mitochondrial SNOs and how they can affect mitochondrion-related cellular process, such as oxidative phosphorylation, mitochondrial dynamics, and mitophagy. |
| format | Article |
| id | doaj-art-84161d500688445eb2aa271c3af6310a |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-84161d500688445eb2aa271c3af6310a2025-02-03T06:11:10ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/361872361872Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation: Implications in Cancer and NeurodegenerationGiuseppina Di Giacomo0Salvatore Rizza1Costanza Montagna2Giuseppe Filomeni3Research Centre IRCCS San Raffaele Pisana, Via di Val Cannuta, 247, 00166 Rome, ItalyDepartment of Biology, University of Rome “Tor Vergata”, Via della Ricerca Scientifica, 00133 Rome, ItalyResearch Centre IRCCS San Raffaele Pisana, Via di Val Cannuta, 247, 00166 Rome, ItalyResearch Centre IRCCS San Raffaele Pisana, Via di Val Cannuta, 247, 00166 Rome, ItalyS-nitrosylation is a posttranslational modification of cysteine residues that has been frequently indicated as potential molecular mechanism governing cell response upon redox unbalance downstream of nitric oxide (over)production. In the last years, increased levels of S-nitrosothiols (SNOs) have been tightly associated with the onset of nitroxidative stress-based pathologies (e.g., cancer and neurodegeneration), conditions in which alterations of mitochondrial homeostasis and activation of cellular processes dependent on it have been reported as well. In this paper we aim at summarizing the current knowledge of mitochondria-related proteins undergoing S-nitrosylation and how this redox modification might impact on mitochondrial functions, whose impairment has been correlated to tumorigenesis and neuronal cell death. In particular, emphasis will be given to the possible, but still neglected implication of denitrosylation reactions in the modulation of mitochondrial SNOs and how they can affect mitochondrion-related cellular process, such as oxidative phosphorylation, mitochondrial dynamics, and mitophagy.http://dx.doi.org/10.1155/2012/361872 |
| spellingShingle | Giuseppina Di Giacomo Salvatore Rizza Costanza Montagna Giuseppe Filomeni Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation: Implications in Cancer and Neurodegeneration International Journal of Cell Biology |
| title | Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation: Implications in Cancer and Neurodegeneration |
| title_full | Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation: Implications in Cancer and Neurodegeneration |
| title_fullStr | Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation: Implications in Cancer and Neurodegeneration |
| title_full_unstemmed | Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation: Implications in Cancer and Neurodegeneration |
| title_short | Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation: Implications in Cancer and Neurodegeneration |
| title_sort | established principles and emerging concepts on the interplay between mitochondrial physiology and s de nitrosylation implications in cancer and neurodegeneration |
| url | http://dx.doi.org/10.1155/2012/361872 |
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