Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B Patients
CD4+ T cells serve as master regulators of the adaptive immune response to HBV. However, CD4+ T-cell subsets are heterogeneous, and it remains unknown how the antiviral agents affect the different CD4+ T cell subtypes. To this end, the expressions of signature transcription factors and cytokines of...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/789859 |
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| author | Yanhua Zheng Zemin Huang Xianhua Chen Yi Tian Jun Tang Yi Zhang Xiaomin Zhang Jijun Zhou Qing Mao Bing Ni Qinghong Wang Yuzhang Wu |
| author_facet | Yanhua Zheng Zemin Huang Xianhua Chen Yi Tian Jun Tang Yi Zhang Xiaomin Zhang Jijun Zhou Qing Mao Bing Ni Qinghong Wang Yuzhang Wu |
| author_sort | Yanhua Zheng |
| collection | DOAJ |
| description | CD4+ T cells serve as master regulators of the adaptive immune response to HBV. However, CD4+ T-cell subsets are heterogeneous, and it remains unknown how the antiviral agents affect the different CD4+ T cell subtypes. To this end, the expressions of signature transcription factors and cytokines of CD4+ T-cell subtypes were examined in hepatitis B patients before and after treatment with telbivudine. Results showed that, upon the rapid HBV copy decrease induced by telbivudine treatment, the frequencies and related cytokines of Th17 and Treg cells were dramatically decreased, while those for Th2 cells were dramatically increased. No obvious changes were observed in Th1 cell frequencies; although, IFN-γ expression was upregulated in response to telbivudine treatment, suggesting another cell source of IFN-γ in CHB patients. Statistical analyses indicated that Th17 and Tr1 (a Treg subtype) cells were the most sensitive subpopulations of the peripheral blood CD4+ T cells to telbivudine treatment over 52 weeks. Thus, Th17 and Tr1 cells may represent a suitable and effective predictor of responsiveness during telbivudine therapy. These findings not only improve our understanding of hepatitis pathogenesis but also can aid in future development of appropriate therapeutic strategies to control viral hepatitis. |
| format | Article |
| id | doaj-art-84095d0e2c114dbd877e1ec8f4b1e957 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-84095d0e2c114dbd877e1ec8f4b1e9572025-02-03T01:02:01ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/789859789859Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B PatientsYanhua Zheng0Zemin Huang1Xianhua Chen2Yi Tian3Jun Tang4Yi Zhang5Xiaomin Zhang6Jijun Zhou7Qing Mao8Bing Ni9Qinghong Wang10Yuzhang Wu11Institute of Immunology, Third Military Medical University, PLA, Chongqing 400038, ChinaInstitute of Immunology, Third Military Medical University, PLA, Chongqing 400038, ChinaDepartment of Health Care, Southwest Hospital, Third Military Medical University, Chongqing 400038, ChinaInstitute of Immunology, Third Military Medical University, PLA, Chongqing 400038, ChinaDepartment of Dermatology, 105th Hospital, PLA, Hefei 230001, ChinaInstitute of Immunology, Third Military Medical University, PLA, Chongqing 400038, ChinaDepartment of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, ChinaDepartment of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, ChinaDepartment of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, ChinaInstitute of Immunology, Third Military Medical University, PLA, Chongqing 400038, ChinaMinistry of Education Key Laboratory of Child Development and Disorders, Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing 400014, ChinaInstitute of Immunology, Third Military Medical University, PLA, Chongqing 400038, ChinaCD4+ T cells serve as master regulators of the adaptive immune response to HBV. However, CD4+ T-cell subsets are heterogeneous, and it remains unknown how the antiviral agents affect the different CD4+ T cell subtypes. To this end, the expressions of signature transcription factors and cytokines of CD4+ T-cell subtypes were examined in hepatitis B patients before and after treatment with telbivudine. Results showed that, upon the rapid HBV copy decrease induced by telbivudine treatment, the frequencies and related cytokines of Th17 and Treg cells were dramatically decreased, while those for Th2 cells were dramatically increased. No obvious changes were observed in Th1 cell frequencies; although, IFN-γ expression was upregulated in response to telbivudine treatment, suggesting another cell source of IFN-γ in CHB patients. Statistical analyses indicated that Th17 and Tr1 (a Treg subtype) cells were the most sensitive subpopulations of the peripheral blood CD4+ T cells to telbivudine treatment over 52 weeks. Thus, Th17 and Tr1 cells may represent a suitable and effective predictor of responsiveness during telbivudine therapy. These findings not only improve our understanding of hepatitis pathogenesis but also can aid in future development of appropriate therapeutic strategies to control viral hepatitis.http://dx.doi.org/10.1155/2012/789859 |
| spellingShingle | Yanhua Zheng Zemin Huang Xianhua Chen Yi Tian Jun Tang Yi Zhang Xiaomin Zhang Jijun Zhou Qing Mao Bing Ni Qinghong Wang Yuzhang Wu Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B Patients Mediators of Inflammation |
| title | Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B Patients |
| title_full | Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B Patients |
| title_fullStr | Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B Patients |
| title_full_unstemmed | Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B Patients |
| title_short | Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B Patients |
| title_sort | effects of telbivudine treatment on the circulating cd4 t cell subpopulations in chronic hepatitis b patients |
| url | http://dx.doi.org/10.1155/2012/789859 |
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