Understanding the potential impact of trimester-specific maternal immune activation due to SARS-CoV-2 on early human neurodevelopment and the role of cytokine balance
Purpose: The COVID-19 pandemic presents significant future health challenges. Its impact on pregnant women and their newborn is a particular area of concern. This study aims to examine the potential role of maternal immune activation (MIA), due to SARS-CoV-2 infection, on early neurodevelopment. Met...
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Elsevier
2025-03-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354625000146 |
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| author | Alexandre Díaz-Pons Sergio Castaño-Castaño Víctor Ortiz-García de la Foz Ángel Yorca-Ruiz Carlos Martínez-Asensi Eva Munarriz-Cuezva Rosa Ayesa-Arriola |
| author_facet | Alexandre Díaz-Pons Sergio Castaño-Castaño Víctor Ortiz-García de la Foz Ángel Yorca-Ruiz Carlos Martínez-Asensi Eva Munarriz-Cuezva Rosa Ayesa-Arriola |
| author_sort | Alexandre Díaz-Pons |
| collection | DOAJ |
| description | Purpose: The COVID-19 pandemic presents significant future health challenges. Its impact on pregnant women and their newborn is a particular area of concern. This study aims to examine the potential role of maternal immune activation (MIA), due to SARS-CoV-2 infection, on early neurodevelopment. Methods: We analysed 107 mother-infant dyads from the COGESTCOV-19 study in Cantabria, Spain, which included 59 SARS-CoV-2 exposed (cases) and 48 unexposed (controls) mothers, recruited between December 2020 and February 2022. Cytokine levels (IL-6 and IL-10) were obtained from maternal blood and cord blood. Neurodevelopment was assessed using the Neonatal Behavioral Assessment Scale (NBAS) at six weeks of age. Trimester of infection was considered in the main analyses. Results: Results showed no significant overall delays in early neurodevelopment due to maternal SARS-CoV-2 infection. Control infants performed better in some NBAS items. However, cases infants showed trimester-specific differences. First-trimester exposure was related to motor and reflex delays, second-trimester to poorer performances in motor tasks and autonomic stability, and third-trimester to weaker state organization, regulation, and reflexes. Some correlations between cytokine levels and NBAS performance showed moderate associations. Conclusions: These findings highlight the need for ongoing neurodevelopmental monitoring of infants born during the COVID-19 pandemic. The study enhances our understanding of MIA's impact on early development, emphasizing the importance of addressing homeostatic mechanisms in mothers and newborns. |
| format | Article |
| id | doaj-art-8408f304ade54153afb6feb64762c34a |
| institution | Kabale University |
| issn | 2666-3546 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj-art-8408f304ade54153afb6feb64762c34a2025-02-04T04:10:36ZengElsevierBrain, Behavior, & Immunity - Health2666-35462025-03-0144100956Understanding the potential impact of trimester-specific maternal immune activation due to SARS-CoV-2 on early human neurodevelopment and the role of cytokine balanceAlexandre Díaz-Pons0Sergio Castaño-Castaño1Víctor Ortiz-García de la Foz2Ángel Yorca-Ruiz3Carlos Martínez-Asensi4Eva Munarriz-Cuezva5Rosa Ayesa-Arriola6Departamento de Investigación en Enfermedades Mentales, Instituto de Investigación Marqués de Valdecilla (IDIVAL), 39011, Santander, Spain; Escuela de Doctorado de la Universidad de Cantabria (EDUC), Universidad de Cantabria (UC), 39005, Santander, Spain; Departamento de Medicina y Ciencias de la Salud, Facultad de Medicina, Universidad de Cantabria (UC), 39011, Santander, Spain; Facultad de Psicología, Universidad Nacional de Educación a Distancia (UNED), 28015, Madrid, SpainDepartamento de Psicobiología, Facultad de Psicología, Universidad de Oviedo (UO), 33003, Oviedo, Spain; Instituto de Neurociencias del Principado de Asturias (INEUROPA), 33003, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011, Oviedo, SpainDepartamento de Investigación en Enfermedades Mentales, Instituto de Investigación Marqués de Valdecilla (IDIVAL), 39011, Santander, SpainDepartamento de Investigación en Enfermedades Mentales, Instituto de Investigación Marqués de Valdecilla (IDIVAL), 39011, Santander, Spain; Escuela de Doctorado de la Universidad de Cantabria (EDUC), Universidad de Cantabria (UC), 39005, Santander, Spain; Departamento de Biología Molecular, Facultad de Medicina, Universidad de Cantabria (UC), 39011, Santander, SpainDepartamento de Investigación en Enfermedades Mentales, Instituto de Investigación Marqués de Valdecilla (IDIVAL), 39011, Santander, Spain; Facultad de Psicología, Universidad Nacional de Educación a Distancia (UNED), 28015, Madrid, SpainDepartamento de Farmacología, Facultad de Medicina y Enfermería, Universidad del País Vasco/ Euskal Herriko Unibertsitatea (UPV/EHU), 48940, Leioa, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029, Madrid, SpainDepartamento de Investigación en Enfermedades Mentales, Instituto de Investigación Marqués de Valdecilla (IDIVAL), 39011, Santander, Spain; Departamento de Medicina y Ciencias de la Salud, Facultad de Medicina, Universidad de Cantabria (UC), 39011, Santander, Spain; Facultad de Psicología, Universidad Nacional de Educación a Distancia (UNED), 28015, Madrid, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029, Madrid, Spain; Corresponding author. Departamento de Investigación en Enfermedades Mentales, Instituto de Investigación Marqués de Valdecilla (IDIVAL), 39011, Santander, Spain.Purpose: The COVID-19 pandemic presents significant future health challenges. Its impact on pregnant women and their newborn is a particular area of concern. This study aims to examine the potential role of maternal immune activation (MIA), due to SARS-CoV-2 infection, on early neurodevelopment. Methods: We analysed 107 mother-infant dyads from the COGESTCOV-19 study in Cantabria, Spain, which included 59 SARS-CoV-2 exposed (cases) and 48 unexposed (controls) mothers, recruited between December 2020 and February 2022. Cytokine levels (IL-6 and IL-10) were obtained from maternal blood and cord blood. Neurodevelopment was assessed using the Neonatal Behavioral Assessment Scale (NBAS) at six weeks of age. Trimester of infection was considered in the main analyses. Results: Results showed no significant overall delays in early neurodevelopment due to maternal SARS-CoV-2 infection. Control infants performed better in some NBAS items. However, cases infants showed trimester-specific differences. First-trimester exposure was related to motor and reflex delays, second-trimester to poorer performances in motor tasks and autonomic stability, and third-trimester to weaker state organization, regulation, and reflexes. Some correlations between cytokine levels and NBAS performance showed moderate associations. Conclusions: These findings highlight the need for ongoing neurodevelopmental monitoring of infants born during the COVID-19 pandemic. The study enhances our understanding of MIA's impact on early development, emphasizing the importance of addressing homeostatic mechanisms in mothers and newborns.http://www.sciencedirect.com/science/article/pii/S2666354625000146Maternal immune activation (MIA)SARS-CoV-2NeurodevelopmentCytokinesHomeostasisNeonatal behavioral assessment scale (NBAS) |
| spellingShingle | Alexandre Díaz-Pons Sergio Castaño-Castaño Víctor Ortiz-García de la Foz Ángel Yorca-Ruiz Carlos Martínez-Asensi Eva Munarriz-Cuezva Rosa Ayesa-Arriola Understanding the potential impact of trimester-specific maternal immune activation due to SARS-CoV-2 on early human neurodevelopment and the role of cytokine balance Brain, Behavior, & Immunity - Health Maternal immune activation (MIA) SARS-CoV-2 Neurodevelopment Cytokines Homeostasis Neonatal behavioral assessment scale (NBAS) |
| title | Understanding the potential impact of trimester-specific maternal immune activation due to SARS-CoV-2 on early human neurodevelopment and the role of cytokine balance |
| title_full | Understanding the potential impact of trimester-specific maternal immune activation due to SARS-CoV-2 on early human neurodevelopment and the role of cytokine balance |
| title_fullStr | Understanding the potential impact of trimester-specific maternal immune activation due to SARS-CoV-2 on early human neurodevelopment and the role of cytokine balance |
| title_full_unstemmed | Understanding the potential impact of trimester-specific maternal immune activation due to SARS-CoV-2 on early human neurodevelopment and the role of cytokine balance |
| title_short | Understanding the potential impact of trimester-specific maternal immune activation due to SARS-CoV-2 on early human neurodevelopment and the role of cytokine balance |
| title_sort | understanding the potential impact of trimester specific maternal immune activation due to sars cov 2 on early human neurodevelopment and the role of cytokine balance |
| topic | Maternal immune activation (MIA) SARS-CoV-2 Neurodevelopment Cytokines Homeostasis Neonatal behavioral assessment scale (NBAS) |
| url | http://www.sciencedirect.com/science/article/pii/S2666354625000146 |
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