Persistently increased post-stress activity of paraventricular thalamic neurons is essential for the emergence of stress-induced alterations in behaviour.
A single exposure to a stressful event can result in enduring changes in behaviour. Long-term modifications in neuronal networks induced by stress are well explored but the initial steps leading to these alterations remain incompletely understood. In this study, we found that acute stress exposure t...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3002962 |
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| author | Anna Jász László Biró Zsolt Buday Bálint Király Orsolya Szalárdy Krisztina Horváth Gergely Komlósi Róbert Bódizs Krisztina J Kovács Marco A Diana Balázs Hangya László Acsády |
| author_facet | Anna Jász László Biró Zsolt Buday Bálint Király Orsolya Szalárdy Krisztina Horváth Gergely Komlósi Róbert Bódizs Krisztina J Kovács Marco A Diana Balázs Hangya László Acsády |
| author_sort | Anna Jász |
| collection | DOAJ |
| description | A single exposure to a stressful event can result in enduring changes in behaviour. Long-term modifications in neuronal networks induced by stress are well explored but the initial steps leading to these alterations remain incompletely understood. In this study, we found that acute stress exposure triggers an immediate increase in the firing activity of calretinin-positive neurons in the paraventricular thalamic nucleus (PVT/CR+) that persists for several days in mice. This increase in activity had a causal role in stress-induced changes in spontaneous behaviour. Attenuating PVT/CR+ neuronal activity for only 1 h after the stress event rescued both the protracted increase in PVT/CR+ firing rate and the stress-induced behavioural alterations. Activation of the key forebrain targets (basolateral amygdala, prelimbic cortex, and nucleus accumbens) that mediate defensive behaviour has also been reduced by this post-stress inhibition. Reduction of PVT/CR+ cell activity 5 days later remained still effective in ameliorating stress-induced changes in spontaneous behaviour. The results demonstrate a critical role of the prolonged, post-stress changes in firing activity of PVT/CR+ neurons in shaping the behavioural changes associated with stress. Our data proposes a therapeutic window for intervention in acute stress-related disorders, offering potential avenues for targeted treatment strategies. |
| format | Article |
| id | doaj-art-840721d9037e48e9b3b9dc22a3ee97e3 |
| institution | Kabale University |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-840721d9037e48e9b3b9dc22a3ee97e32025-02-05T05:30:18ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852025-01-01231e300296210.1371/journal.pbio.3002962Persistently increased post-stress activity of paraventricular thalamic neurons is essential for the emergence of stress-induced alterations in behaviour.Anna JászLászló BiróZsolt BudayBálint KirályOrsolya SzalárdyKrisztina HorváthGergely KomlósiRóbert BódizsKrisztina J KovácsMarco A DianaBalázs HangyaLászló AcsádyA single exposure to a stressful event can result in enduring changes in behaviour. Long-term modifications in neuronal networks induced by stress are well explored but the initial steps leading to these alterations remain incompletely understood. In this study, we found that acute stress exposure triggers an immediate increase in the firing activity of calretinin-positive neurons in the paraventricular thalamic nucleus (PVT/CR+) that persists for several days in mice. This increase in activity had a causal role in stress-induced changes in spontaneous behaviour. Attenuating PVT/CR+ neuronal activity for only 1 h after the stress event rescued both the protracted increase in PVT/CR+ firing rate and the stress-induced behavioural alterations. Activation of the key forebrain targets (basolateral amygdala, prelimbic cortex, and nucleus accumbens) that mediate defensive behaviour has also been reduced by this post-stress inhibition. Reduction of PVT/CR+ cell activity 5 days later remained still effective in ameliorating stress-induced changes in spontaneous behaviour. The results demonstrate a critical role of the prolonged, post-stress changes in firing activity of PVT/CR+ neurons in shaping the behavioural changes associated with stress. Our data proposes a therapeutic window for intervention in acute stress-related disorders, offering potential avenues for targeted treatment strategies.https://doi.org/10.1371/journal.pbio.3002962 |
| spellingShingle | Anna Jász László Biró Zsolt Buday Bálint Király Orsolya Szalárdy Krisztina Horváth Gergely Komlósi Róbert Bódizs Krisztina J Kovács Marco A Diana Balázs Hangya László Acsády Persistently increased post-stress activity of paraventricular thalamic neurons is essential for the emergence of stress-induced alterations in behaviour. PLoS Biology |
| title | Persistently increased post-stress activity of paraventricular thalamic neurons is essential for the emergence of stress-induced alterations in behaviour. |
| title_full | Persistently increased post-stress activity of paraventricular thalamic neurons is essential for the emergence of stress-induced alterations in behaviour. |
| title_fullStr | Persistently increased post-stress activity of paraventricular thalamic neurons is essential for the emergence of stress-induced alterations in behaviour. |
| title_full_unstemmed | Persistently increased post-stress activity of paraventricular thalamic neurons is essential for the emergence of stress-induced alterations in behaviour. |
| title_short | Persistently increased post-stress activity of paraventricular thalamic neurons is essential for the emergence of stress-induced alterations in behaviour. |
| title_sort | persistently increased post stress activity of paraventricular thalamic neurons is essential for the emergence of stress induced alterations in behaviour |
| url | https://doi.org/10.1371/journal.pbio.3002962 |
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