Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome
We aimed to explore the mechanism of the linoleic acid metabolism in metabolic syndrome (MetS). RNA-seq data for 16 samples with or without MetS from the GSE145412 dataset were collected. Gene set variation analysis (GSVA), gene set enrichment analysis (GSEA), and gene differential expression analys...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Genetics Research |
| Online Access: | http://dx.doi.org/10.1155/2022/6793346 |
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| author | Yan Wen Yawen Shang Qing Wang |
| author_facet | Yan Wen Yawen Shang Qing Wang |
| author_sort | Yan Wen |
| collection | DOAJ |
| description | We aimed to explore the mechanism of the linoleic acid metabolism in metabolic syndrome (MetS). RNA-seq data for 16 samples with or without MetS from the GSE145412 dataset were collected. Gene set variation analysis (GSVA), gene set enrichment analysis (GSEA), and gene differential expression analysis were performed. Expression data of differentially expressed genes (DEGs) involved in the linoleic acid metabolism pathway were mapped to the pathway by using Pathview for visualization. There were 19 and 10 differentially expressed biological processes in the disease group and healthy group, respectively. 9 KEGG pathways were differentially expressed in the disease group. Linoleic acid metabolism was the only differentially expressed pathway in the healthy group. The GSVA enrichment score of the linoleic acid metabolism pathway in the disease group was markedly lower than that in the healthy group. The GSEA result showed that the linoleic acid metabolism pathway was significantly downregulated in the disease group. JMJD7-PLA2G4B, PLA2G1B, PLA2G2D, CYP2C8, and CYP2J2 involved in the pathway were significantly downregulated in the disease group. This study may provide novel insight into MetS from the point of linoleic acid metabolism dysregulation. |
| format | Article |
| id | doaj-art-83fdfb83893e4ee7bc4192bbd02bbdcf |
| institution | Kabale University |
| issn | 1469-5073 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Genetics Research |
| spelling | doaj-art-83fdfb83893e4ee7bc4192bbd02bbdcf2025-08-20T03:37:38ZengWileyGenetics Research1469-50732022-01-01202210.1155/2022/6793346Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic SyndromeYan Wen0Yawen Shang1Qing Wang2Department of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyWe aimed to explore the mechanism of the linoleic acid metabolism in metabolic syndrome (MetS). RNA-seq data for 16 samples with or without MetS from the GSE145412 dataset were collected. Gene set variation analysis (GSVA), gene set enrichment analysis (GSEA), and gene differential expression analysis were performed. Expression data of differentially expressed genes (DEGs) involved in the linoleic acid metabolism pathway were mapped to the pathway by using Pathview for visualization. There were 19 and 10 differentially expressed biological processes in the disease group and healthy group, respectively. 9 KEGG pathways were differentially expressed in the disease group. Linoleic acid metabolism was the only differentially expressed pathway in the healthy group. The GSVA enrichment score of the linoleic acid metabolism pathway in the disease group was markedly lower than that in the healthy group. The GSEA result showed that the linoleic acid metabolism pathway was significantly downregulated in the disease group. JMJD7-PLA2G4B, PLA2G1B, PLA2G2D, CYP2C8, and CYP2J2 involved in the pathway were significantly downregulated in the disease group. This study may provide novel insight into MetS from the point of linoleic acid metabolism dysregulation.http://dx.doi.org/10.1155/2022/6793346 |
| spellingShingle | Yan Wen Yawen Shang Qing Wang Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome Genetics Research |
| title | Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome |
| title_full | Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome |
| title_fullStr | Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome |
| title_full_unstemmed | Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome |
| title_short | Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome |
| title_sort | exploration of the mechanism of linoleic acid metabolism dysregulation in metabolic syndrome |
| url | http://dx.doi.org/10.1155/2022/6793346 |
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