Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides
Histone deacetylase (HDAC) inhibitors have shown significant activity in the treatment of cutaneous T-cell lymphomas (CTCL). The epigenetic alterations of CTCL not only are limited to altered histone acetylation but also include aberrant DNA gene methylation hence, the combination of an HDAC inhibit...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/657579 |
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| _version_ | 1832547584235798528 |
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| author | Alfonso Dueñas-Gonzalez Maria Teresa Vega Déborah Martinez-Baños Linda García-Hidalgo Pedro Sobrevilla |
| author_facet | Alfonso Dueñas-Gonzalez Maria Teresa Vega Déborah Martinez-Baños Linda García-Hidalgo Pedro Sobrevilla |
| author_sort | Alfonso Dueñas-Gonzalez |
| collection | DOAJ |
| description | Histone deacetylase (HDAC) inhibitors have shown significant activity in the treatment of cutaneous T-cell lymphomas (CTCL). The epigenetic alterations of CTCL not only are limited to altered histone acetylation but also include aberrant DNA gene methylation hence, the combination of an HDAC inhibitor with a DNA demethylating agent is a promising therapy to be tested. Here we report a mycosis fungoides patient having a dramatic response to hydralazine and valproate, two repositioned drugs as HDAC and DNA methylation inhibitors, respectively. |
| format | Article |
| id | doaj-art-83eea36434924563accb7fc138b74b57 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-83eea36434924563accb7fc138b74b572025-02-03T06:44:14ZengWileyCase Reports in Medicine1687-96271687-96352010-01-01201010.1155/2010/657579657579Response to Hydralazine-Valproate in a Patient with Mycosis FungoidesAlfonso Dueñas-Gonzalez0Maria Teresa Vega1Déborah Martinez-Baños2Linda García-Hidalgo3Pedro Sobrevilla4Unidad de Investigación Biomédica en Cancer, Instituto de Investigaciones Biomédicas, Instituto Nacional de Cancerología, UNAM, San Fernando 22, Tlalpan 14080, Mexico City, MexicoDepartment of Dermatology, Instituto Nacional de Cancerología, Tlalpan 14080, Mexico City, MexicoDepartment of Hematology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan 14080, Mexico City, MexicoDepartment of Dermatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan 14080, Mexico City, MexicoDepartment of Hematology, Instituto Nacional de Cancerología, Tlalpan 14080, Mexico City, MexicoHistone deacetylase (HDAC) inhibitors have shown significant activity in the treatment of cutaneous T-cell lymphomas (CTCL). The epigenetic alterations of CTCL not only are limited to altered histone acetylation but also include aberrant DNA gene methylation hence, the combination of an HDAC inhibitor with a DNA demethylating agent is a promising therapy to be tested. Here we report a mycosis fungoides patient having a dramatic response to hydralazine and valproate, two repositioned drugs as HDAC and DNA methylation inhibitors, respectively.http://dx.doi.org/10.1155/2010/657579 |
| spellingShingle | Alfonso Dueñas-Gonzalez Maria Teresa Vega Déborah Martinez-Baños Linda García-Hidalgo Pedro Sobrevilla Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides Case Reports in Medicine |
| title | Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides |
| title_full | Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides |
| title_fullStr | Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides |
| title_full_unstemmed | Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides |
| title_short | Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides |
| title_sort | response to hydralazine valproate in a patient with mycosis fungoides |
| url | http://dx.doi.org/10.1155/2010/657579 |
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