New Spectrophotometric Method for the Determination of Bosentan - An Anti-Hypertensive Agent in Pharmaceutical Dosage Forms
A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of Bosentan in bulk and in pharmaceutical formulations. Bosentan exhibits absorption maxima at 273 nm with apparent molar absorptivity of 1.3293×104 L/mol.cm in methanol and octane 1-...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/359745 |
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| _version_ | 1832545378279358464 |
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| author | A. Narendra D. Deepika M. Mathrusri Annapurna |
| author_facet | A. Narendra D. Deepika M. Mathrusri Annapurna |
| author_sort | A. Narendra |
| collection | DOAJ |
| description | A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of Bosentan in bulk and in pharmaceutical formulations. Bosentan exhibits absorption maxima at 273 nm with apparent molar absorptivity of 1.3293×104 L/mol.cm in methanol and octane 1-sulfonic acid solvent mixture. Beer's law was found to be obeyed in the concentration range of 0.1-100 μg/mL. The method was validated as per the ICH guidelines. |
| format | Article |
| id | doaj-art-83ec81831fef4feb9ea156d277a30a83 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-83ec81831fef4feb9ea156d277a30a832025-02-03T07:26:02ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-019270070410.1155/2012/359745New Spectrophotometric Method for the Determination of Bosentan - An Anti-Hypertensive Agent in Pharmaceutical Dosage FormsA. Narendra0D. Deepika1M. Mathrusri Annapurna2Department of Pharmaceutical analysis and Quality Assurance, Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa, IndiaRoyal College of Pharmacy and Health Sciences, Berhampur, Orissa, IndiaGITAM Institute of Pharmacy, GITAM University, Visakhapatnam, IndiaA new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of Bosentan in bulk and in pharmaceutical formulations. Bosentan exhibits absorption maxima at 273 nm with apparent molar absorptivity of 1.3293×104 L/mol.cm in methanol and octane 1-sulfonic acid solvent mixture. Beer's law was found to be obeyed in the concentration range of 0.1-100 μg/mL. The method was validated as per the ICH guidelines.http://dx.doi.org/10.1155/2012/359745 |
| spellingShingle | A. Narendra D. Deepika M. Mathrusri Annapurna New Spectrophotometric Method for the Determination of Bosentan - An Anti-Hypertensive Agent in Pharmaceutical Dosage Forms E-Journal of Chemistry |
| title | New Spectrophotometric Method for the Determination of Bosentan - An Anti-Hypertensive Agent in Pharmaceutical Dosage Forms |
| title_full | New Spectrophotometric Method for the Determination of Bosentan - An Anti-Hypertensive Agent in Pharmaceutical Dosage Forms |
| title_fullStr | New Spectrophotometric Method for the Determination of Bosentan - An Anti-Hypertensive Agent in Pharmaceutical Dosage Forms |
| title_full_unstemmed | New Spectrophotometric Method for the Determination of Bosentan - An Anti-Hypertensive Agent in Pharmaceutical Dosage Forms |
| title_short | New Spectrophotometric Method for the Determination of Bosentan - An Anti-Hypertensive Agent in Pharmaceutical Dosage Forms |
| title_sort | new spectrophotometric method for the determination of bosentan an anti hypertensive agent in pharmaceutical dosage forms |
| url | http://dx.doi.org/10.1155/2012/359745 |
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