Acute high-intensity interval exercise is superior to moderate-intensity continuous exercise in enhancing endothelial function and its associated biomarkers in sedentary young individuals: the possible involvement of lactate
Abstracts: Objectives: Our study investigated the effects of acute high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) on endothelial function and its associated biomarkers in sedentary young individuals. Methods: Fifteen subjects (10M / 5F; 22 ± 2 years; BMI:...
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Elsevier
2025-01-01
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| Series: | Journal of Exercise Science & Fitness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1728869X24000832 |
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| author | Ziqing Liu Jinglin Huang Min Hu Xuyan Cui Lu Leng Kangle Wang Jiarui Wu Shan He Weiji Deng Peilun Li Yilin Chen Dongdong Gao Haijie Yu Junhao Huang |
| author_facet | Ziqing Liu Jinglin Huang Min Hu Xuyan Cui Lu Leng Kangle Wang Jiarui Wu Shan He Weiji Deng Peilun Li Yilin Chen Dongdong Gao Haijie Yu Junhao Huang |
| author_sort | Ziqing Liu |
| collection | DOAJ |
| description | Abstracts: Objectives: Our study investigated the effects of acute high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) on endothelial function and its associated biomarkers in sedentary young individuals. Methods: Fifteen subjects (10M / 5F; 22 ± 2 years; BMI: 23.07 ± 4.12 kg/m2) participated in a crossover trial including three experimental conditions: HIIE, MICE, and a control session of rest (CON) in random order separated by a 7-day washout period. Endothelial function was assessed using flow-mediated dilation (FMD), mean shear rate (MSR), and circulating levels of blood lactate, VEGF, IGF-1, and irisin. Results: Both HIIE and MICE significantly enhanced FMD% (both P < 0.001 and P < 0.01, respectively), lactate (both P < 0.001), VEGF (P < 0.001 and P < 0.01, respectively), IGF-1 (both P < 0.001), and irisin (P < 0.001 and P < 0.05, respectively), with a greater extent after HIIE compared to MICE in FMD% (P < 0.001), MSR (P < 0.05), lactate (P < 0.001), VEGF (P < 0.05), and IGF-1 (P < 0.05). Additionally, change (post-pre) in FMD% was positively correlated with changes in MSR, lactate, and VEGF in both HIIE and MICE conditions. Change in MSR was positively associated with changes in lactate and VEGF in both HIIE and MICE conditions. Furthermore, enhancement in lactate was correlated with enhancements in VEGF in both HIIE and MICE conditions. Conclusions: Acute HIIE is a more effective method than MICE at improving endothelial function in sedentary young individuals and increases in lactate and its mediated VEGF release, attributed to increase in shear rate after exercise, are involved in regulatory mechanisms. |
| format | Article |
| id | doaj-art-83d985687df44de2a1674c1d43e1f551 |
| institution | Kabale University |
| issn | 1728-869X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Exercise Science & Fitness |
| spelling | doaj-art-83d985687df44de2a1674c1d43e1f5512025-02-06T05:11:24ZengElsevierJournal of Exercise Science & Fitness1728-869X2025-01-012316068Acute high-intensity interval exercise is superior to moderate-intensity continuous exercise in enhancing endothelial function and its associated biomarkers in sedentary young individuals: the possible involvement of lactateZiqing Liu0Jinglin Huang1Min Hu2Xuyan Cui3Lu Leng4Kangle Wang5Jiarui Wu6Shan He7Weiji Deng8Peilun Li9Yilin Chen10Dongdong Gao11Haijie Yu12Junhao Huang13Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, Guangdong, ChinaGuangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, Guangdong, ChinaGuangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, Guangdong, ChinaGuangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, Guangdong, ChinaCollege of Foreign Languages, Jinan University, Guangzhou, Guangdong, ChinaGuangdong Polytechnic of Science and Technology, Zhuhai, Guangdong, ChinaPanyu District Health Management Center (Panyu Rehabilitation Hospital), Guangzhou, Guangdong, ChinaDepartment of Health and Physical Education, The Education University of Hong Kong, Hong Kong Special Administrative Region of ChinaGuangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, Guangdong, ChinaGuangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, Guangdong, ChinaGuangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, Guangdong, ChinaGuangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, Guangdong, ChinaDr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, ChinaGuangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, Guangdong, China; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China; Corresponding author. Guangzhou Sport University, 1268 Middle Guangzhou Avenue, Guangzhou, 510500, China.Abstracts: Objectives: Our study investigated the effects of acute high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) on endothelial function and its associated biomarkers in sedentary young individuals. Methods: Fifteen subjects (10M / 5F; 22 ± 2 years; BMI: 23.07 ± 4.12 kg/m2) participated in a crossover trial including three experimental conditions: HIIE, MICE, and a control session of rest (CON) in random order separated by a 7-day washout period. Endothelial function was assessed using flow-mediated dilation (FMD), mean shear rate (MSR), and circulating levels of blood lactate, VEGF, IGF-1, and irisin. Results: Both HIIE and MICE significantly enhanced FMD% (both P < 0.001 and P < 0.01, respectively), lactate (both P < 0.001), VEGF (P < 0.001 and P < 0.01, respectively), IGF-1 (both P < 0.001), and irisin (P < 0.001 and P < 0.05, respectively), with a greater extent after HIIE compared to MICE in FMD% (P < 0.001), MSR (P < 0.05), lactate (P < 0.001), VEGF (P < 0.05), and IGF-1 (P < 0.05). Additionally, change (post-pre) in FMD% was positively correlated with changes in MSR, lactate, and VEGF in both HIIE and MICE conditions. Change in MSR was positively associated with changes in lactate and VEGF in both HIIE and MICE conditions. Furthermore, enhancement in lactate was correlated with enhancements in VEGF in both HIIE and MICE conditions. Conclusions: Acute HIIE is a more effective method than MICE at improving endothelial function in sedentary young individuals and increases in lactate and its mediated VEGF release, attributed to increase in shear rate after exercise, are involved in regulatory mechanisms.http://www.sciencedirect.com/science/article/pii/S1728869X24000832High-intensity interval exerciseModerate-intensity continuous exerciseEndothelial functionLactate |
| spellingShingle | Ziqing Liu Jinglin Huang Min Hu Xuyan Cui Lu Leng Kangle Wang Jiarui Wu Shan He Weiji Deng Peilun Li Yilin Chen Dongdong Gao Haijie Yu Junhao Huang Acute high-intensity interval exercise is superior to moderate-intensity continuous exercise in enhancing endothelial function and its associated biomarkers in sedentary young individuals: the possible involvement of lactate Journal of Exercise Science & Fitness High-intensity interval exercise Moderate-intensity continuous exercise Endothelial function Lactate |
| title | Acute high-intensity interval exercise is superior to moderate-intensity continuous exercise in enhancing endothelial function and its associated biomarkers in sedentary young individuals: the possible involvement of lactate |
| title_full | Acute high-intensity interval exercise is superior to moderate-intensity continuous exercise in enhancing endothelial function and its associated biomarkers in sedentary young individuals: the possible involvement of lactate |
| title_fullStr | Acute high-intensity interval exercise is superior to moderate-intensity continuous exercise in enhancing endothelial function and its associated biomarkers in sedentary young individuals: the possible involvement of lactate |
| title_full_unstemmed | Acute high-intensity interval exercise is superior to moderate-intensity continuous exercise in enhancing endothelial function and its associated biomarkers in sedentary young individuals: the possible involvement of lactate |
| title_short | Acute high-intensity interval exercise is superior to moderate-intensity continuous exercise in enhancing endothelial function and its associated biomarkers in sedentary young individuals: the possible involvement of lactate |
| title_sort | acute high intensity interval exercise is superior to moderate intensity continuous exercise in enhancing endothelial function and its associated biomarkers in sedentary young individuals the possible involvement of lactate |
| topic | High-intensity interval exercise Moderate-intensity continuous exercise Endothelial function Lactate |
| url | http://www.sciencedirect.com/science/article/pii/S1728869X24000832 |
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