Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis
Interleukin-8 has long been recognized to have anti-inflammatory activity, which has been established in various models of infection, inflammation, and cancer. Several cell types express the receptor for the cytokine IL-8 and upon its recognition produce molecules that are active both locally and sy...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.4061/2011/908468 |
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| author | Basit Saleem Qazi Kai Tang Asma Qazi |
| author_facet | Basit Saleem Qazi Kai Tang Asma Qazi |
| author_sort | Basit Saleem Qazi |
| collection | DOAJ |
| description | Interleukin-8 has long been recognized to have anti-inflammatory activity, which has been established in various models of infection, inflammation, and cancer. Several cell types express the receptor for the cytokine IL-8 and upon its recognition produce molecules that are active both locally and systemically. Many different types of cells, in particular monocytes, neutrophils, epithelial, fibroblast, endothelial, mesothelial, and tumor cells, secrete IL-8. Increased expression of IL-8 and/or its receptors has been characterized in many chronic inflammatory conditions, including psoriasis, ARDS, COPD, and RA as well as many cancers, and its upregulation often correlates with disease activity. IL-8 constitutes the CXC class of chemokines, a potent chemoattractant and activator of neutrophils and other immune cells. It is a proangiogenic cytokine that is overexpressed in many human cancers. Therefore, inhibiting the effects of IL-8 signaling may be a significant therapeutic intervention. |
| format | Article |
| id | doaj-art-83d4926d6f444098ab26d5cadbed10aa |
| institution | Kabale University |
| issn | 2042-0099 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-83d4926d6f444098ab26d5cadbed10aa2025-02-03T01:12:26ZengWileyInternational Journal of Inflammation2042-00992011-01-01201110.4061/2011/908468908468Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and AngiogenesisBasit Saleem Qazi0Kai Tang1Asma Qazi2Department of Orthopedic Surgery Spine Unit, First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian, Liaoning 116011, ChinaDepartment of Orthopedic Surgery Spine Unit, First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian, Liaoning 116011, ChinaDepartment of Pathology and Pathophysiology, Dalian Medical University, 9 West Section Lvshun South Road, Lvshun District, Dalian, Liaoning 116044, ChinaInterleukin-8 has long been recognized to have anti-inflammatory activity, which has been established in various models of infection, inflammation, and cancer. Several cell types express the receptor for the cytokine IL-8 and upon its recognition produce molecules that are active both locally and systemically. Many different types of cells, in particular monocytes, neutrophils, epithelial, fibroblast, endothelial, mesothelial, and tumor cells, secrete IL-8. Increased expression of IL-8 and/or its receptors has been characterized in many chronic inflammatory conditions, including psoriasis, ARDS, COPD, and RA as well as many cancers, and its upregulation often correlates with disease activity. IL-8 constitutes the CXC class of chemokines, a potent chemoattractant and activator of neutrophils and other immune cells. It is a proangiogenic cytokine that is overexpressed in many human cancers. Therefore, inhibiting the effects of IL-8 signaling may be a significant therapeutic intervention.http://dx.doi.org/10.4061/2011/908468 |
| spellingShingle | Basit Saleem Qazi Kai Tang Asma Qazi Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis International Journal of Inflammation |
| title | Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis |
| title_full | Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis |
| title_fullStr | Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis |
| title_full_unstemmed | Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis |
| title_short | Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis |
| title_sort | recent advances in underlying pathologies provide insight into interleukin 8 expression mediated inflammation and angiogenesis |
| url | http://dx.doi.org/10.4061/2011/908468 |
| work_keys_str_mv | AT basitsaleemqazi recentadvancesinunderlyingpathologiesprovideinsightintointerleukin8expressionmediatedinflammationandangiogenesis AT kaitang recentadvancesinunderlyingpathologiesprovideinsightintointerleukin8expressionmediatedinflammationandangiogenesis AT asmaqazi recentadvancesinunderlyingpathologiesprovideinsightintointerleukin8expressionmediatedinflammationandangiogenesis |