Does hormone replacement therapy impact implant osseointegration in females- A systematic review and meta-analysis
Background: This review aimed to comprehensively investigate the impact of Hormone Replacement Therapy (HRT) on implant osseointegration and bone loss. The study considered factors such as HRT type, osteoporosis, smoking, and diabetes mellitus, and analysed the available literature to provide insigh...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2024-03-01
|
| Series: | Saudi Dental Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905223002183 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850037650222743552 |
|---|---|
| author | Tushar Sinha Jayant Prakash Mahesh Suganna Golgeri Daginakatti Shambhulingappa Aruna Bukanakere Sangappa Sunila Ganiga Channaiah Shivakumar Marco Cicciù Giuseppe Minervini |
| author_facet | Tushar Sinha Jayant Prakash Mahesh Suganna Golgeri Daginakatti Shambhulingappa Aruna Bukanakere Sangappa Sunila Ganiga Channaiah Shivakumar Marco Cicciù Giuseppe Minervini |
| author_sort | Tushar Sinha |
| collection | DOAJ |
| description | Background: This review aimed to comprehensively investigate the impact of Hormone Replacement Therapy (HRT) on implant osseointegration and bone loss. The study considered factors such as HRT type, osteoporosis, smoking, and diabetes mellitus, and analysed the available literature to provide insights into the association between HRT and implant outcomes. Methods: Multiple databases were utilized, and studies with diverse designs and methodologies were included that examined the relationship between HRT and implant osseointegration. The selected studies were analyzed and relevant data on implant success rates, bone loss, and other correlations was extracted. Results: The review findings indicate that HRT has a detrimental impact on implant osseointegration, as evidenced by lower implant success rates and increased bone loss in HRT-treated individuals. The odds ratio analysis further strengthens this association, with significant values of 0.59 (95% CI: 0.50–0.70) and 0.64 (95% CI: 0.54–0.76), indicating a higher likelihood of implant failure in HRT-treated patients., highlighting the need for caution when considering HRT as a treatment option in patients undergoing implant procedures. Smoking and diabetes mellitus were also found to significantly affect implant outcomes, emphasizing the importance of addressing these factors in patient management. Conclusion: The assessments demonstrate that HRT adversely affects implant osseointegration and increases bone loss. The results suggest the importance of considering the potential negative impact of HRT on implant outcomes and the need for thorough patient evaluation and management. Further research is warranted to explore the underlying mechanisms, assess the impact of specific HRT types and dosages, and evaluate preventive strategies to mitigate the detrimental effects of HRT on implant success. |
| format | Article |
| id | doaj-art-83d3f36b9035419c9db74d0a1d535f90 |
| institution | DOAJ |
| issn | 1013-9052 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Springer |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj-art-83d3f36b9035419c9db74d0a1d535f902025-08-20T02:56:47ZengSpringerSaudi Dental Journal1013-90522024-03-0136342042710.1016/j.sdentj.2023.10.021Does hormone replacement therapy impact implant osseointegration in females- A systematic review and meta-analysisTushar Sinha0Jayant Prakash1Mahesh Suganna Golgeri2Daginakatti Shambhulingappa Aruna3Bukanakere Sangappa Sunila4Ganiga Channaiah Shivakumar5Marco Cicciù6Giuseppe Minervini7Dept of Prosthodontics, Dental college, Rajendra institute of medical sciences, RIMS, Ranchi, Jharkhand, IndiaSadar Hospital, Muzaffarpur 842001, Bihar, India; Corresponding authors.Assistant Professor, Department of Prosthodontics, Riyadh Elm University, Riyadh, Saudi ArabiaPGD Health Promotion, CTCS, Dental Public health Consultant and tobacco cessation specialist, Bengaluru, IndiaDepartment of Prosthodontics and Crown & Bridge, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, IndiaDepartment of Oral Medicine and Radiology, People’s College of Dental Sciences and Research Centre, People’s University, Bhopal 462037, IndiaDepartment of Biomedical and Surgical and Biomedical Sciences, Catania University, 95123, Catania, ItalySaveetha Dental College & Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai 600 077, India; Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania, Luigi Vanvitelli, 80138 Naples, Italy; Corresponding authors.Background: This review aimed to comprehensively investigate the impact of Hormone Replacement Therapy (HRT) on implant osseointegration and bone loss. The study considered factors such as HRT type, osteoporosis, smoking, and diabetes mellitus, and analysed the available literature to provide insights into the association between HRT and implant outcomes. Methods: Multiple databases were utilized, and studies with diverse designs and methodologies were included that examined the relationship between HRT and implant osseointegration. The selected studies were analyzed and relevant data on implant success rates, bone loss, and other correlations was extracted. Results: The review findings indicate that HRT has a detrimental impact on implant osseointegration, as evidenced by lower implant success rates and increased bone loss in HRT-treated individuals. The odds ratio analysis further strengthens this association, with significant values of 0.59 (95% CI: 0.50–0.70) and 0.64 (95% CI: 0.54–0.76), indicating a higher likelihood of implant failure in HRT-treated patients., highlighting the need for caution when considering HRT as a treatment option in patients undergoing implant procedures. Smoking and diabetes mellitus were also found to significantly affect implant outcomes, emphasizing the importance of addressing these factors in patient management. Conclusion: The assessments demonstrate that HRT adversely affects implant osseointegration and increases bone loss. The results suggest the importance of considering the potential negative impact of HRT on implant outcomes and the need for thorough patient evaluation and management. Further research is warranted to explore the underlying mechanisms, assess the impact of specific HRT types and dosages, and evaluate preventive strategies to mitigate the detrimental effects of HRT on implant success.http://www.sciencedirect.com/science/article/pii/S1013905223002183Hormone Replacement TherapyHRTImplant osseointegrationBone lossImplant failure |
| spellingShingle | Tushar Sinha Jayant Prakash Mahesh Suganna Golgeri Daginakatti Shambhulingappa Aruna Bukanakere Sangappa Sunila Ganiga Channaiah Shivakumar Marco Cicciù Giuseppe Minervini Does hormone replacement therapy impact implant osseointegration in females- A systematic review and meta-analysis Saudi Dental Journal Hormone Replacement Therapy HRT Implant osseointegration Bone loss Implant failure |
| title | Does hormone replacement therapy impact implant osseointegration in females- A systematic review and meta-analysis |
| title_full | Does hormone replacement therapy impact implant osseointegration in females- A systematic review and meta-analysis |
| title_fullStr | Does hormone replacement therapy impact implant osseointegration in females- A systematic review and meta-analysis |
| title_full_unstemmed | Does hormone replacement therapy impact implant osseointegration in females- A systematic review and meta-analysis |
| title_short | Does hormone replacement therapy impact implant osseointegration in females- A systematic review and meta-analysis |
| title_sort | does hormone replacement therapy impact implant osseointegration in females a systematic review and meta analysis |
| topic | Hormone Replacement Therapy HRT Implant osseointegration Bone loss Implant failure |
| url | http://www.sciencedirect.com/science/article/pii/S1013905223002183 |
| work_keys_str_mv | AT tusharsinha doeshormonereplacementtherapyimpactimplantosseointegrationinfemalesasystematicreviewandmetaanalysis AT jayantprakash doeshormonereplacementtherapyimpactimplantosseointegrationinfemalesasystematicreviewandmetaanalysis AT maheshsugannagolgeri doeshormonereplacementtherapyimpactimplantosseointegrationinfemalesasystematicreviewandmetaanalysis AT daginakattishambhulingappaaruna doeshormonereplacementtherapyimpactimplantosseointegrationinfemalesasystematicreviewandmetaanalysis AT bukanakeresangappasunila doeshormonereplacementtherapyimpactimplantosseointegrationinfemalesasystematicreviewandmetaanalysis AT ganigachannaiahshivakumar doeshormonereplacementtherapyimpactimplantosseointegrationinfemalesasystematicreviewandmetaanalysis AT marcocicciu doeshormonereplacementtherapyimpactimplantosseointegrationinfemalesasystematicreviewandmetaanalysis AT giuseppeminervini doeshormonereplacementtherapyimpactimplantosseointegrationinfemalesasystematicreviewandmetaanalysis |