Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis
Purpose. To evaluate the ability of new swept-source (SS) optical coherence tomography (OCT) technology to detect changes in retinal and choroidal thickness in patients with multiple sclerosis (MS). Methods. A total of 101 healthy and 97 MS eyes underwent retinal and choroidal assessment using SS Tr...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2018/7361212 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563852771852288 |
|---|---|
| author | Elena Garcia-Martin Laura Jarauta Elisa Vilades Jose Ramon Ara Jesus Martin Vicente Polo Jose Manuel Larrosa Luis Emilio Pablo Maria Satue |
| author_facet | Elena Garcia-Martin Laura Jarauta Elisa Vilades Jose Ramon Ara Jesus Martin Vicente Polo Jose Manuel Larrosa Luis Emilio Pablo Maria Satue |
| author_sort | Elena Garcia-Martin |
| collection | DOAJ |
| description | Purpose. To evaluate the ability of new swept-source (SS) optical coherence tomography (OCT) technology to detect changes in retinal and choroidal thickness in patients with multiple sclerosis (MS). Methods. A total of 101 healthy and 97 MS eyes underwent retinal and choroidal assessment using SS Triton OCT (Topcon). Macular thickness and peripapillary data (retinal, ganglion cell layer (GCL+, GCL++) and retinal nerve fiber layer (RNFL) thickness) were analyzed, including choroidal thickness evaluation. Results. Significant macular thinning was observed in all ETDRS areas (p<0.001) in MS patients. Peripapillary retinal, RNFL, and GCL ++ thickness showed a significant reduction in patients in all sectors (p<0.001) except in the nasal quadrant/sector (p>0.05). GCL+ measurements were found to be reduced in the nasal (p=0.003), inferonasal (p=0.045), and temporal (p=0.001) sectors and total thickness (p<0.001). Choroidal thickness was reduced in the outer macular ring in MS patients compared with controls (p=0.038). Conclusion. New swept-source technology for OCT devices detects retinal thinning in MS patients, providing increased depth analysis of the choroid in these patients. MS patients present reduced retinal and choroidal thickness in the macular area and reduced peripapillary retinal, RNFL, and GCL thickness. |
| format | Article |
| id | doaj-art-83c0470664e14beab659ba15052aa549 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-83c0470664e14beab659ba15052aa5492025-02-03T01:12:26ZengWileyJournal of Ophthalmology2090-004X2090-00582018-01-01201810.1155/2018/73612127361212Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple SclerosisElena Garcia-Martin0Laura Jarauta1Elisa Vilades2Jose Ramon Ara3Jesus Martin4Vicente Polo5Jose Manuel Larrosa6Luis Emilio Pablo7Maria Satue8Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, SpainIIS-Aragon. Aragon Institute for Health Sciences, Zaragoza, SpainOphthalmology Department, Miguel Servet University Hospital, Zaragoza, SpainIIS-Aragon. Aragon Institute for Health Sciences, Zaragoza, SpainIIS-Aragon. Aragon Institute for Health Sciences, Zaragoza, SpainOphthalmology Department, Miguel Servet University Hospital, Zaragoza, SpainOphthalmology Department, Miguel Servet University Hospital, Zaragoza, SpainOphthalmology Department, Miguel Servet University Hospital, Zaragoza, SpainOphthalmology Department, Miguel Servet University Hospital, Zaragoza, SpainPurpose. To evaluate the ability of new swept-source (SS) optical coherence tomography (OCT) technology to detect changes in retinal and choroidal thickness in patients with multiple sclerosis (MS). Methods. A total of 101 healthy and 97 MS eyes underwent retinal and choroidal assessment using SS Triton OCT (Topcon). Macular thickness and peripapillary data (retinal, ganglion cell layer (GCL+, GCL++) and retinal nerve fiber layer (RNFL) thickness) were analyzed, including choroidal thickness evaluation. Results. Significant macular thinning was observed in all ETDRS areas (p<0.001) in MS patients. Peripapillary retinal, RNFL, and GCL ++ thickness showed a significant reduction in patients in all sectors (p<0.001) except in the nasal quadrant/sector (p>0.05). GCL+ measurements were found to be reduced in the nasal (p=0.003), inferonasal (p=0.045), and temporal (p=0.001) sectors and total thickness (p<0.001). Choroidal thickness was reduced in the outer macular ring in MS patients compared with controls (p=0.038). Conclusion. New swept-source technology for OCT devices detects retinal thinning in MS patients, providing increased depth analysis of the choroid in these patients. MS patients present reduced retinal and choroidal thickness in the macular area and reduced peripapillary retinal, RNFL, and GCL thickness.http://dx.doi.org/10.1155/2018/7361212 |
| spellingShingle | Elena Garcia-Martin Laura Jarauta Elisa Vilades Jose Ramon Ara Jesus Martin Vicente Polo Jose Manuel Larrosa Luis Emilio Pablo Maria Satue Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis Journal of Ophthalmology |
| title | Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis |
| title_full | Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis |
| title_fullStr | Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis |
| title_full_unstemmed | Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis |
| title_short | Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis |
| title_sort | ability of swept source optical coherence tomography to detect retinal and choroidal changes in patients with multiple sclerosis |
| url | http://dx.doi.org/10.1155/2018/7361212 |
| work_keys_str_mv | AT elenagarciamartin abilityofsweptsourceopticalcoherencetomographytodetectretinalandchoroidalchangesinpatientswithmultiplesclerosis AT laurajarauta abilityofsweptsourceopticalcoherencetomographytodetectretinalandchoroidalchangesinpatientswithmultiplesclerosis AT elisavilades abilityofsweptsourceopticalcoherencetomographytodetectretinalandchoroidalchangesinpatientswithmultiplesclerosis AT joseramonara abilityofsweptsourceopticalcoherencetomographytodetectretinalandchoroidalchangesinpatientswithmultiplesclerosis AT jesusmartin abilityofsweptsourceopticalcoherencetomographytodetectretinalandchoroidalchangesinpatientswithmultiplesclerosis AT vicentepolo abilityofsweptsourceopticalcoherencetomographytodetectretinalandchoroidalchangesinpatientswithmultiplesclerosis AT josemanuellarrosa abilityofsweptsourceopticalcoherencetomographytodetectretinalandchoroidalchangesinpatientswithmultiplesclerosis AT luisemiliopablo abilityofsweptsourceopticalcoherencetomographytodetectretinalandchoroidalchangesinpatientswithmultiplesclerosis AT mariasatue abilityofsweptsourceopticalcoherencetomographytodetectretinalandchoroidalchangesinpatientswithmultiplesclerosis |