The Research Progress of Monoclonal Antibody Labeled with 89Zr
Zirconium-89 (89Zr) is a metallic positron-emitting radionuclide. The relatively long half-life and moderate energy making 89Zr especially suitable for the labeling of large biomolecules such as antibodies for radioimmuno-PET (positron emission tomography) imaging. In recent years，significant progre...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Board of Journal of Isotopes
2025-04-01
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| Series: | Journal of Isotopes |
| Subjects: | |
| Online Access: | https://tws.xml-journal.net/article/doi/10.7538/tws.2024.youxian.093 |
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| Summary: | Zirconium-89 (89Zr) is a metallic positron-emitting radionuclide. The relatively long half-life and moderate energy making 89Zr especially suitable for the labeling of large biomolecules such as antibodies for radioimmuno-PET (positron emission tomography) imaging. In recent years，significant progress has been made in the research of 89Zr-labeled monoclonal antibodies (mAbs)，driven by the development of mAb therapies. Currently，some of these mAb drugs have entered clinical phases II and III. In the labeling methods of 89Zr，deferoxamine B (DFO) is the most commonly used chelator and has been applied in clinical research. However，researchers are still continually exploring better ligands. In terms of chelator-mAb conjugation techniques，various forms of DFO derivatives remain the primary focus of research. In this article，89Zr labeling methods，chelator conjugation techniques，and advances in 89Zr-mAbs were reviewed. The challenges，issues，and future trends of 89Zr-mAbs has also been discussed and prospected. |
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| ISSN: | 1000-7512 |