Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature review
Cryptococcal endophthalmitis is a rare manifestation of cryptococcal infection, typically occurring in immunocompromised patients. In this case report, we present a 50-year-old female with advanced-stage lung cancer with multiple metastases presenting with blurred vision for 10 days. A diagnostic pa...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Medical Mycology Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211753925000120 |
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| author | Kamonchanok Phaopraphat Rujipas Sirijatuphat |
| author_facet | Kamonchanok Phaopraphat Rujipas Sirijatuphat |
| author_sort | Kamonchanok Phaopraphat |
| collection | DOAJ |
| description | Cryptococcal endophthalmitis is a rare manifestation of cryptococcal infection, typically occurring in immunocompromised patients. In this case report, we present a 50-year-old female with advanced-stage lung cancer with multiple metastases presenting with blurred vision for 10 days. A diagnostic pars plana vitrectomy revealed Cryptococcus neoformans in the vitreous. She was treated with systemic amphotericin B and flucytosine, followed by fluconazole for consolidation and maintenance, along with intravitreal amphotericin B and voriconazole injections. Her visual acuity improved from counting fingers at 2 feet to 3/60, with a pinhole correction of 6/18 after 10 months of treatment. |
| format | Article |
| id | doaj-art-83b0a1e3d85f43c99b0ff9a74c376b76 |
| institution | Kabale University |
| issn | 2211-7539 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medical Mycology Case Reports |
| spelling | doaj-art-83b0a1e3d85f43c99b0ff9a74c376b762025-08-20T03:45:28ZengElsevierMedical Mycology Case Reports2211-75392025-06-014810070310.1016/j.mmcr.2025.100703Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature reviewKamonchanok Phaopraphat0Rujipas Sirijatuphat1Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandCorresponding author.; Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandCryptococcal endophthalmitis is a rare manifestation of cryptococcal infection, typically occurring in immunocompromised patients. In this case report, we present a 50-year-old female with advanced-stage lung cancer with multiple metastases presenting with blurred vision for 10 days. A diagnostic pars plana vitrectomy revealed Cryptococcus neoformans in the vitreous. She was treated with systemic amphotericin B and flucytosine, followed by fluconazole for consolidation and maintenance, along with intravitreal amphotericin B and voriconazole injections. Her visual acuity improved from counting fingers at 2 feet to 3/60, with a pinhole correction of 6/18 after 10 months of treatment.http://www.sciencedirect.com/science/article/pii/S2211753925000120 |
| spellingShingle | Kamonchanok Phaopraphat Rujipas Sirijatuphat Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature review Medical Mycology Case Reports |
| title | Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature review |
| title_full | Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature review |
| title_fullStr | Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature review |
| title_full_unstemmed | Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature review |
| title_short | Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature review |
| title_sort | cryptococcal endophthalmitis in a patient with malignancy a case report and literature review |
| url | http://www.sciencedirect.com/science/article/pii/S2211753925000120 |
| work_keys_str_mv | AT kamonchanokphaopraphat cryptococcalendophthalmitisinapatientwithmalignancyacasereportandliteraturereview AT rujipassirijatuphat cryptococcalendophthalmitisinapatientwithmalignancyacasereportandliteraturereview |