Digit Tip Injuries: Current Treatment and Future Regenerative Paradigms
Over the past several decades there has been a profound increase in the understanding of tissue regeneration, driven largely by the observance of the tremendous regenerative capacity in lower order life forms, such as hydra and urodeles. However, it is known that humans and other mammals retain the...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/9619080 |
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| _version_ | 1832562117074485248 |
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| author | Travis J. Miller Peter L. Deptula Gregory M. Buncke Zeshaan N. Maan |
| author_facet | Travis J. Miller Peter L. Deptula Gregory M. Buncke Zeshaan N. Maan |
| author_sort | Travis J. Miller |
| collection | DOAJ |
| description | Over the past several decades there has been a profound increase in the understanding of tissue regeneration, driven largely by the observance of the tremendous regenerative capacity in lower order life forms, such as hydra and urodeles. However, it is known that humans and other mammals retain the ability to regenerate the distal phalanges of the digits after amputation. Despite the increased knowledge base on model organisms regarding regenerative paradigms, there is a lack of application of regenerative medicine techniques in clinical practice in regard to digit tip injury. Here, we review the current understanding of digit tip regeneration and discuss gaps that remain in translating regenerative medicine into clinical treatment of digit amputation. |
| format | Article |
| id | doaj-art-83a561475f10497cb130b5762f37ebeb |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-83a561475f10497cb130b5762f37ebeb2025-02-03T01:23:20ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/96190809619080Digit Tip Injuries: Current Treatment and Future Regenerative ParadigmsTravis J. Miller0Peter L. Deptula1Gregory M. Buncke2Zeshaan N. Maan3Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94304, USADepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94304, USAThe Buncke Clinic, San Francisco, CA 94114, USADepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94304, USAOver the past several decades there has been a profound increase in the understanding of tissue regeneration, driven largely by the observance of the tremendous regenerative capacity in lower order life forms, such as hydra and urodeles. However, it is known that humans and other mammals retain the ability to regenerate the distal phalanges of the digits after amputation. Despite the increased knowledge base on model organisms regarding regenerative paradigms, there is a lack of application of regenerative medicine techniques in clinical practice in regard to digit tip injury. Here, we review the current understanding of digit tip regeneration and discuss gaps that remain in translating regenerative medicine into clinical treatment of digit amputation.http://dx.doi.org/10.1155/2019/9619080 |
| spellingShingle | Travis J. Miller Peter L. Deptula Gregory M. Buncke Zeshaan N. Maan Digit Tip Injuries: Current Treatment and Future Regenerative Paradigms Stem Cells International |
| title | Digit Tip Injuries: Current Treatment and Future Regenerative Paradigms |
| title_full | Digit Tip Injuries: Current Treatment and Future Regenerative Paradigms |
| title_fullStr | Digit Tip Injuries: Current Treatment and Future Regenerative Paradigms |
| title_full_unstemmed | Digit Tip Injuries: Current Treatment and Future Regenerative Paradigms |
| title_short | Digit Tip Injuries: Current Treatment and Future Regenerative Paradigms |
| title_sort | digit tip injuries current treatment and future regenerative paradigms |
| url | http://dx.doi.org/10.1155/2019/9619080 |
| work_keys_str_mv | AT travisjmiller digittipinjuriescurrenttreatmentandfutureregenerativeparadigms AT peterldeptula digittipinjuriescurrenttreatmentandfutureregenerativeparadigms AT gregorymbuncke digittipinjuriescurrenttreatmentandfutureregenerativeparadigms AT zeshaannmaan digittipinjuriescurrenttreatmentandfutureregenerativeparadigms |