Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed?
Childhood tuberculosis (TB) is a significant public health problem and the ninth leading cause of death worldwide. Progression of Mycobacterium tuberculosis infection to active disease depends on mycobacterial virulence, environmental diversity, and host susceptibility and immune response. In childr...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/8235149 |
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| author | Laura E. Carreto-Binaghi Esmeralda Juárez Silvia Guzmán-Beltrán María Teresa Herrera Martha Torres Alejandro Alejandre José Arturo Martínez-Orozco Eduardo Becerril-Vargas Yolanda Gonzalez |
| author_facet | Laura E. Carreto-Binaghi Esmeralda Juárez Silvia Guzmán-Beltrán María Teresa Herrera Martha Torres Alejandro Alejandre José Arturo Martínez-Orozco Eduardo Becerril-Vargas Yolanda Gonzalez |
| author_sort | Laura E. Carreto-Binaghi |
| collection | DOAJ |
| description | Childhood tuberculosis (TB) is a significant public health problem and the ninth leading cause of death worldwide. Progression of Mycobacterium tuberculosis infection to active disease depends on mycobacterial virulence, environmental diversity, and host susceptibility and immune response. In children, malnutrition and immaturity of the immune system contribute to an inadequate immune response. Coinfections, though rarely described in TB, might be associated with host immune deficiencies. Here, we describe the immunological evaluation of eight pediatric patients infected with a member of the M. tuberculosis complex, most of them with concomitant pulmonary infections (bacteria, viruses, or fungi). We assessed the functionality of several innate immunity receptors, IL-12 receptor, and IFN-γ receptor, as well as the antioxidant levels (glutathione), which are essential mechanisms for fighting intracellular pathogens such as M. tuberculosis. This study is aimed at developing a thorough immunological evaluation of patients with TB and a coinfection. |
| format | Article |
| id | doaj-art-83924682af7d4174b2680564c3e11d9b |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-83924682af7d4174b2680564c3e11d9b2025-02-03T01:01:28ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/82351498235149Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed?Laura E. Carreto-Binaghi0Esmeralda Juárez1Silvia Guzmán-Beltrán2María Teresa Herrera3Martha Torres4Alejandro Alejandre5José Arturo Martínez-Orozco6Eduardo Becerril-Vargas7Yolanda Gonzalez8Microbiology Research Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, CDMX 14080, MexicoMicrobiology Research Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, CDMX 14080, MexicoMicrobiology Research Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, CDMX 14080, MexicoMicrobiology Research Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, CDMX 14080, MexicoMicrobiology Research Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, CDMX 14080, MexicoPediatric Pulmonology Clinical Ward, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, CDMX 14080, MexicoClinical Microbiology Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, CDMX 14080, MexicoClinical Microbiology Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, CDMX 14080, MexicoMicrobiology Research Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, CDMX 14080, MexicoChildhood tuberculosis (TB) is a significant public health problem and the ninth leading cause of death worldwide. Progression of Mycobacterium tuberculosis infection to active disease depends on mycobacterial virulence, environmental diversity, and host susceptibility and immune response. In children, malnutrition and immaturity of the immune system contribute to an inadequate immune response. Coinfections, though rarely described in TB, might be associated with host immune deficiencies. Here, we describe the immunological evaluation of eight pediatric patients infected with a member of the M. tuberculosis complex, most of them with concomitant pulmonary infections (bacteria, viruses, or fungi). We assessed the functionality of several innate immunity receptors, IL-12 receptor, and IFN-γ receptor, as well as the antioxidant levels (glutathione), which are essential mechanisms for fighting intracellular pathogens such as M. tuberculosis. This study is aimed at developing a thorough immunological evaluation of patients with TB and a coinfection.http://dx.doi.org/10.1155/2020/8235149 |
| spellingShingle | Laura E. Carreto-Binaghi Esmeralda Juárez Silvia Guzmán-Beltrán María Teresa Herrera Martha Torres Alejandro Alejandre José Arturo Martínez-Orozco Eduardo Becerril-Vargas Yolanda Gonzalez Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed? Journal of Immunology Research |
| title | Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed? |
| title_full | Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed? |
| title_fullStr | Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed? |
| title_full_unstemmed | Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed? |
| title_short | Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed? |
| title_sort | immunological evaluation for personalized interventions in children with tuberculosis should it be routinely performed |
| url | http://dx.doi.org/10.1155/2020/8235149 |
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