Multivariate Analysis of the Ocular Response Analyzer’s Corneal Deformation Response Curve for Early Keratoconus Detection
Purpose. To thoroughly analyze corneal deformation responses curves obtained by Ocular Response Analyzer (ORA) testing in order to improve subclinical keratoconus detection. Methods. Observational case series of 87 control and 73 subclinical keratoconus eyes. Examination included corneal topography,...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/496382 |
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| author | Jonatán D. Galletti Pablo R. Ruiseñor Vázquez Fernando Fuentes Bonthoux Tomás Pförtner Jeremías G. Galletti |
| author_facet | Jonatán D. Galletti Pablo R. Ruiseñor Vázquez Fernando Fuentes Bonthoux Tomás Pförtner Jeremías G. Galletti |
| author_sort | Jonatán D. Galletti |
| collection | DOAJ |
| description | Purpose. To thoroughly analyze corneal deformation responses curves obtained by Ocular Response Analyzer (ORA) testing in order to improve subclinical keratoconus detection. Methods. Observational case series of 87 control and 73 subclinical keratoconus eyes. Examination included corneal topography, tomography, and biomechanical testing with ORA. Factor analysis, logistic regression, and receiver operating characteristic curves were used to extract combinations of 45 corneal waveform descriptors. Main outcome measures were corneal-thickness-corrected corneal resistance factor (ccCRF), combinations of corneal descriptors, and their diagnostic performance. Results. Thirty-seven descriptors differed significantly in means between groups, and among them ccCRF afforded the highest individual diagnostic performance. Factor analysis identified first- and second-peak related descriptors as the most variable one. However, conventional biomechanical descriptors corneal resistance factor and hysteresis differed the most between control and keratoconic eyes. A combination of three factors including several corneal descriptors did not show better diagnostic performance than a combination of conventional indices. Conclusion. Multivariate analysis of ORA signals did not surpass simpler models in subclinical keratoconus detection, and there is considerable overlap between normal and ectatic eyes irrespective of the analysis model. Conventional biomechanical indices seem to already provide the best performance when appropriately considered. |
| format | Article |
| id | doaj-art-83847ed80eab47f69cd336a1c4915786 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-83847ed80eab47f69cd336a1c49157862025-02-03T01:11:40ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/496382496382Multivariate Analysis of the Ocular Response Analyzer’s Corneal Deformation Response Curve for Early Keratoconus DetectionJonatán D. Galletti0Pablo R. Ruiseñor Vázquez1Fernando Fuentes Bonthoux2Tomás Pförtner3Jeremías G. Galletti4ECOS (Clinical Ocular Studies) Laboratory, Pueyrredón 1716, 1119 Buenos Aires, ArgentinaECOS (Clinical Ocular Studies) Laboratory, Pueyrredón 1716, 1119 Buenos Aires, ArgentinaECOS (Clinical Ocular Studies) Laboratory, Pueyrredón 1716, 1119 Buenos Aires, ArgentinaECOS (Clinical Ocular Studies) Laboratory, Pueyrredón 1716, 1119 Buenos Aires, ArgentinaECOS (Clinical Ocular Studies) Laboratory, Pueyrredón 1716, 1119 Buenos Aires, ArgentinaPurpose. To thoroughly analyze corneal deformation responses curves obtained by Ocular Response Analyzer (ORA) testing in order to improve subclinical keratoconus detection. Methods. Observational case series of 87 control and 73 subclinical keratoconus eyes. Examination included corneal topography, tomography, and biomechanical testing with ORA. Factor analysis, logistic regression, and receiver operating characteristic curves were used to extract combinations of 45 corneal waveform descriptors. Main outcome measures were corneal-thickness-corrected corneal resistance factor (ccCRF), combinations of corneal descriptors, and their diagnostic performance. Results. Thirty-seven descriptors differed significantly in means between groups, and among them ccCRF afforded the highest individual diagnostic performance. Factor analysis identified first- and second-peak related descriptors as the most variable one. However, conventional biomechanical descriptors corneal resistance factor and hysteresis differed the most between control and keratoconic eyes. A combination of three factors including several corneal descriptors did not show better diagnostic performance than a combination of conventional indices. Conclusion. Multivariate analysis of ORA signals did not surpass simpler models in subclinical keratoconus detection, and there is considerable overlap between normal and ectatic eyes irrespective of the analysis model. Conventional biomechanical indices seem to already provide the best performance when appropriately considered.http://dx.doi.org/10.1155/2015/496382 |
| spellingShingle | Jonatán D. Galletti Pablo R. Ruiseñor Vázquez Fernando Fuentes Bonthoux Tomás Pförtner Jeremías G. Galletti Multivariate Analysis of the Ocular Response Analyzer’s Corneal Deformation Response Curve for Early Keratoconus Detection Journal of Ophthalmology |
| title | Multivariate Analysis of the Ocular Response Analyzer’s Corneal Deformation Response Curve for Early Keratoconus Detection |
| title_full | Multivariate Analysis of the Ocular Response Analyzer’s Corneal Deformation Response Curve for Early Keratoconus Detection |
| title_fullStr | Multivariate Analysis of the Ocular Response Analyzer’s Corneal Deformation Response Curve for Early Keratoconus Detection |
| title_full_unstemmed | Multivariate Analysis of the Ocular Response Analyzer’s Corneal Deformation Response Curve for Early Keratoconus Detection |
| title_short | Multivariate Analysis of the Ocular Response Analyzer’s Corneal Deformation Response Curve for Early Keratoconus Detection |
| title_sort | multivariate analysis of the ocular response analyzer s corneal deformation response curve for early keratoconus detection |
| url | http://dx.doi.org/10.1155/2015/496382 |
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