Synthesis, antibacterial evaluation and in silico studies of novel 2-(benzo[d]thiazol-2-yl)-N-arylacetamides and their derivatives as potential DHFR inhibitors

Synthesis, antibacterial evaluation and in silico studies of novel 2-(benzo[d]thiazol-2-yl)-N-arylacetamides and their derivatives as potential DHFR inhibitors

Abstract Novel N-arylacetamides 2a–f were synthesized based on benzo[d]thiazole scaffold. The compounds 2a–c underwent Knoevenagel condensation through green synthetic method with different aromatic aldehydes and pyrazole-7-carbaldehydes delivered the respective arylidenes with efficient yields. Ary...

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Bibliographic Details
Main Authors: Nadia Hanafy Metwally, Galal Hamza Elgemeie, Aya Ragab Abdelrazek, Salwa Magdy Eldaly
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Chemistry
Subjects:
Synthesis
ADME studies
Benzo[d]thiazole
Coumarins
N-arylpyridone
DFT
Online Access:https://doi.org/10.1186/s13065-025-01386-5
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