Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity
The helix-loop-helix (HLH) transcription factor inhibitor of DNA binding 2 (Id2) has been implicated as a regulator of hematopoiesis and embryonic development. While its role in early lymphopoiesis has been well characterized, new roles in adaptive immune responses have recently been uncovered openi...
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| Format: | Article |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/281569 |
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| author | Lucille Rankin Gabrielle T. Belz |
| author_facet | Lucille Rankin Gabrielle T. Belz |
| author_sort | Lucille Rankin |
| collection | DOAJ |
| description | The helix-loop-helix (HLH) transcription factor inhibitor of DNA binding 2 (Id2) has been implicated as a regulator of hematopoiesis and embryonic development. While its role in early lymphopoiesis has been well characterized, new roles in adaptive immune responses have recently been uncovered opening exciting new directions for investigation. In the innate immune system, Id2 is required for the development of mature natural killer (NK) cells, lymphoid tissue-inducer (LTi) cells, and the recently identified interleukin (IL)-22 secreting nonconventional innate lymphocytes found in the gut. In addition, Id2 has been implicated in the development of specific dendritic cell (DC) subsets, decisions determining the formation of αβ and γδ T-cell development, NK T-cell behaviour, and in the maintenance of effector and memory CD8+ T cells in peripheral tissues. Here, we review the current understanding of the role of Id2 in lymphopoiesis and in the development of the adaptive immune response required for maintaining immune homeostasis and immune protection. |
| format | Article |
| id | doaj-art-838081bb9c2c4986bccbfdfab50a6cdc |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
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| series | Clinical and Developmental Immunology |
| spelling | doaj-art-838081bb9c2c4986bccbfdfab50a6cdc2025-02-03T01:22:15ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/281569281569Diverse Roles of Inhibitor of Differentiation 2 in Adaptive ImmunityLucille Rankin0Gabrielle T. Belz1Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, AustraliaDivision of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, AustraliaThe helix-loop-helix (HLH) transcription factor inhibitor of DNA binding 2 (Id2) has been implicated as a regulator of hematopoiesis and embryonic development. While its role in early lymphopoiesis has been well characterized, new roles in adaptive immune responses have recently been uncovered opening exciting new directions for investigation. In the innate immune system, Id2 is required for the development of mature natural killer (NK) cells, lymphoid tissue-inducer (LTi) cells, and the recently identified interleukin (IL)-22 secreting nonconventional innate lymphocytes found in the gut. In addition, Id2 has been implicated in the development of specific dendritic cell (DC) subsets, decisions determining the formation of αβ and γδ T-cell development, NK T-cell behaviour, and in the maintenance of effector and memory CD8+ T cells in peripheral tissues. Here, we review the current understanding of the role of Id2 in lymphopoiesis and in the development of the adaptive immune response required for maintaining immune homeostasis and immune protection.http://dx.doi.org/10.1155/2011/281569 |
| spellingShingle | Lucille Rankin Gabrielle T. Belz Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity Clinical and Developmental Immunology |
| title | Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity |
| title_full | Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity |
| title_fullStr | Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity |
| title_full_unstemmed | Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity |
| title_short | Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity |
| title_sort | diverse roles of inhibitor of differentiation 2 in adaptive immunity |
| url | http://dx.doi.org/10.1155/2011/281569 |
| work_keys_str_mv | AT lucillerankin diverserolesofinhibitorofdifferentiation2inadaptiveimmunity AT gabrielletbelz diverserolesofinhibitorofdifferentiation2inadaptiveimmunity |