Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1
The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced sepsis-induced mortality and lung in...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/354087 |
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| author | Xiao-hui Li Xia Gong Li Zhang Rong Jiang Hong-zhong Li Meng-jiao Wu Jing-yuan Wan |
| author_facet | Xiao-hui Li Xia Gong Li Zhang Rong Jiang Hong-zhong Li Meng-jiao Wu Jing-yuan Wan |
| author_sort | Xiao-hui Li |
| collection | DOAJ |
| description | The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced sepsis-induced mortality and lung injury, as indicated by alleviated lung pathological changes and infiltration of proteins and leukocytes. In addition, PD inhibited CLP-induced serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) production, lung cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase isoform (iNOS) protein expressions and NF-κB activation. Notably, PD upregulated the expression and activity of heme oxygenase (HO-)1 in lung tissue of septic mice. Further, the protective effects of PD on sepsis were abrogated by ZnPP IX, a specific HO-1 inhibitor. These findings indicated that PD might be an effective antisepsis drug. |
| format | Article |
| id | doaj-art-837d5711a958420195832ae59da9b9ee |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-837d5711a958420195832ae59da9b9ee2025-02-03T05:50:42ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/354087354087Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1Xiao-hui Li0Xia Gong1Li Zhang2Rong Jiang3Hong-zhong Li4Meng-jiao Wu5Jing-yuan Wan6Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Anatamy, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Pathophysiology, Chongqing Medical University, Chongqing 400016, ChinaLaboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing 400016, ChinaChongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, ChinaChongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, ChinaChongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, ChinaThe present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced sepsis-induced mortality and lung injury, as indicated by alleviated lung pathological changes and infiltration of proteins and leukocytes. In addition, PD inhibited CLP-induced serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) production, lung cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase isoform (iNOS) protein expressions and NF-κB activation. Notably, PD upregulated the expression and activity of heme oxygenase (HO-)1 in lung tissue of septic mice. Further, the protective effects of PD on sepsis were abrogated by ZnPP IX, a specific HO-1 inhibitor. These findings indicated that PD might be an effective antisepsis drug.http://dx.doi.org/10.1155/2013/354087 |
| spellingShingle | Xiao-hui Li Xia Gong Li Zhang Rong Jiang Hong-zhong Li Meng-jiao Wu Jing-yuan Wan Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1 Mediators of Inflammation |
| title | Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1 |
| title_full | Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1 |
| title_fullStr | Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1 |
| title_full_unstemmed | Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1 |
| title_short | Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1 |
| title_sort | protective effects of polydatin on septic lung injury in mice via upregulation of ho 1 |
| url | http://dx.doi.org/10.1155/2013/354087 |
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