Optimizing non-invasive vagus nerve stimulation for treatment in stroke
Stroke remains a leading cause of long-term disability worldwide. There is an unmet need for neuromodulatory therapies that can mitigate against neurovascular injury and potentially promote neurological recovery. Transcutaneous vagus nerve stimulation has been demonstrated to show potential therapeu...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-12-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/NRR.NRR-D-24-00945 |
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| _version_ | 1832086660666359808 |
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| author | Sheharyar S. Baig Samantha Dorney Mudasar Aziz Simon M. Bell Ali N. Ali Li Su Jessica N. Redgrave Arshad Majid |
| author_facet | Sheharyar S. Baig Samantha Dorney Mudasar Aziz Simon M. Bell Ali N. Ali Li Su Jessica N. Redgrave Arshad Majid |
| author_sort | Sheharyar S. Baig |
| collection | DOAJ |
| description | Stroke remains a leading cause of long-term disability worldwide. There is an unmet need for neuromodulatory therapies that can mitigate against neurovascular injury and potentially promote neurological recovery. Transcutaneous vagus nerve stimulation has been demonstrated to show potential therapeutic effects in both acute and chronic stroke. However, previously published research has only investigated a narrow range of stimulation settings and indications. In this review, we detail the ongoing studies of transcutaneous vagus nerve stimulation in stroke through systematic searches of registered clinical trials. We summarize the upcoming clinical trials of transcutaneous vagus nerve stimulation in stroke, highlighting their indications, parameter settings, scope, and limitations. We further explore the challenges and barriers associated with the implementation of transcutaneous vagus nerve stimulation in acute stroke and stroke rehabilitation, focusing on critical aspects such as stimulation settings, target groups, biomarkers, and integration with rehabilitation interventions. |
| format | Article |
| id | doaj-art-8375a12f82924c20a8f05b97e626f17a |
| institution | Kabale University |
| issn | 1673-5374 1876-7958 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj-art-8375a12f82924c20a8f05b97e626f17a2025-02-06T09:58:38ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53741876-79582025-12-0120123388339910.4103/NRR.NRR-D-24-00945Optimizing non-invasive vagus nerve stimulation for treatment in strokeSheharyar S. BaigSamantha DorneyMudasar AzizSimon M. BellAli N. AliLi SuJessica N. RedgraveArshad MajidStroke remains a leading cause of long-term disability worldwide. There is an unmet need for neuromodulatory therapies that can mitigate against neurovascular injury and potentially promote neurological recovery. Transcutaneous vagus nerve stimulation has been demonstrated to show potential therapeutic effects in both acute and chronic stroke. However, previously published research has only investigated a narrow range of stimulation settings and indications. In this review, we detail the ongoing studies of transcutaneous vagus nerve stimulation in stroke through systematic searches of registered clinical trials. We summarize the upcoming clinical trials of transcutaneous vagus nerve stimulation in stroke, highlighting their indications, parameter settings, scope, and limitations. We further explore the challenges and barriers associated with the implementation of transcutaneous vagus nerve stimulation in acute stroke and stroke rehabilitation, focusing on critical aspects such as stimulation settings, target groups, biomarkers, and integration with rehabilitation interventions.https://journals.lww.com/10.4103/NRR.NRR-D-24-00945neuromodulationneuroplasticityrehabilitationstrokevagal nerve stimulationvagus nerve stimulation |
| spellingShingle | Sheharyar S. Baig Samantha Dorney Mudasar Aziz Simon M. Bell Ali N. Ali Li Su Jessica N. Redgrave Arshad Majid Optimizing non-invasive vagus nerve stimulation for treatment in stroke Neural Regeneration Research neuromodulation neuroplasticity rehabilitation stroke vagal nerve stimulation vagus nerve stimulation |
| title | Optimizing non-invasive vagus nerve stimulation for treatment in stroke |
| title_full | Optimizing non-invasive vagus nerve stimulation for treatment in stroke |
| title_fullStr | Optimizing non-invasive vagus nerve stimulation for treatment in stroke |
| title_full_unstemmed | Optimizing non-invasive vagus nerve stimulation for treatment in stroke |
| title_short | Optimizing non-invasive vagus nerve stimulation for treatment in stroke |
| title_sort | optimizing non invasive vagus nerve stimulation for treatment in stroke |
| topic | neuromodulation neuroplasticity rehabilitation stroke vagal nerve stimulation vagus nerve stimulation |
| url | https://journals.lww.com/10.4103/NRR.NRR-D-24-00945 |
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