Sildenafil Treatment of Primary Pulmonary Hypertension
A 37-year-old woman with primary pulmonary hypertension and worsening symptomatology underwent pulmonary artery (PA) catheterization and vasodilator trials. Oxygen had no effect, but 10 parts/million of nitric oxide reduced mean PA (PAm) pressure by 20%. Prostacyclin infusion at 8 ng/kg/min decrease...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2003-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2003/612905 |
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| _version_ | 1832565866960519168 |
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| author | Kevin B Laupland Doug Helmersen David A Zygun Sidney M Viner |
| author_facet | Kevin B Laupland Doug Helmersen David A Zygun Sidney M Viner |
| author_sort | Kevin B Laupland |
| collection | DOAJ |
| description | A 37-year-old woman with primary pulmonary hypertension and worsening symptomatology underwent pulmonary artery (PA) catheterization and vasodilator trials. Oxygen had no effect, but 10 parts/million of nitric oxide reduced mean PA (PAm) pressure by 20%. Prostacyclin infusion at 8 ng/kg/min decreased the PAm pressure by 11%, but further dose increases were limited by systemic hypotension. Sildenafil in doses of 25 mg or higher resulted in an average decrease of 14% in PAm pressure. Sildenafil is a potentially useful treatment option for patients with primary pulmonary hypertension, and further investigation is warranted. |
| format | Article |
| id | doaj-art-836a332ca0a046dbbf448dfcd5aa47ad |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-836a332ca0a046dbbf448dfcd5aa47ad2025-02-03T01:06:18ZengWileyCanadian Respiratory Journal1198-22412003-01-01101485010.1155/2003/612905Sildenafil Treatment of Primary Pulmonary HypertensionKevin B Laupland0Doug Helmersen1David A Zygun2Sidney M Viner3Department of Critical Care Medicine, University of Calgary and the Calgary Health Region, Calgary, Alberta, CanadaDepartment of Medicine, University of Calgary and the Calgary Health Region, Calgary, Alberta, CanadaDepartment of Critical Care Medicine, University of Calgary and the Calgary Health Region, Calgary, Alberta, CanadaDepartment of Critical Care Medicine, University of Calgary and the Calgary Health Region, Calgary, Alberta, CanadaA 37-year-old woman with primary pulmonary hypertension and worsening symptomatology underwent pulmonary artery (PA) catheterization and vasodilator trials. Oxygen had no effect, but 10 parts/million of nitric oxide reduced mean PA (PAm) pressure by 20%. Prostacyclin infusion at 8 ng/kg/min decreased the PAm pressure by 11%, but further dose increases were limited by systemic hypotension. Sildenafil in doses of 25 mg or higher resulted in an average decrease of 14% in PAm pressure. Sildenafil is a potentially useful treatment option for patients with primary pulmonary hypertension, and further investigation is warranted.http://dx.doi.org/10.1155/2003/612905 |
| spellingShingle | Kevin B Laupland Doug Helmersen David A Zygun Sidney M Viner Sildenafil Treatment of Primary Pulmonary Hypertension Canadian Respiratory Journal |
| title | Sildenafil Treatment of Primary Pulmonary Hypertension |
| title_full | Sildenafil Treatment of Primary Pulmonary Hypertension |
| title_fullStr | Sildenafil Treatment of Primary Pulmonary Hypertension |
| title_full_unstemmed | Sildenafil Treatment of Primary Pulmonary Hypertension |
| title_short | Sildenafil Treatment of Primary Pulmonary Hypertension |
| title_sort | sildenafil treatment of primary pulmonary hypertension |
| url | http://dx.doi.org/10.1155/2003/612905 |
| work_keys_str_mv | AT kevinblaupland sildenafiltreatmentofprimarypulmonaryhypertension AT doughelmersen sildenafiltreatmentofprimarypulmonaryhypertension AT davidazygun sildenafiltreatmentofprimarypulmonaryhypertension AT sidneymviner sildenafiltreatmentofprimarypulmonaryhypertension |