Pivotal Roles of GM-CSF in Autoimmunity and Inflammation
Granulocyte macrophage-colony stimulating factor (GM-CSF) is a hematopoietic growth factor, which stimulates the proliferation of granulocytes and macrophages from bone marrow precursor cells. In autoimmune and inflammatory diseases, Th17 cells have been considered as strong inducers of tissue infla...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/568543 |
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| _version_ | 1832549312961183744 |
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| author | Aoi Shiomi Takashi Usui |
| author_facet | Aoi Shiomi Takashi Usui |
| author_sort | Aoi Shiomi |
| collection | DOAJ |
| description | Granulocyte macrophage-colony stimulating factor (GM-CSF) is a hematopoietic growth factor, which stimulates the proliferation of granulocytes and macrophages from bone marrow precursor cells. In autoimmune and inflammatory diseases, Th17 cells have been considered as strong inducers of tissue inflammation. However, recent evidence indicates that GM-CSF has prominent proinflammatory functions and that this growth factor (not IL-17) is critical for the pathogenicity of CD4+ T cells. Therefore, the mechanism of GM-CSF-producing CD4+ T cell differentiation and the role of GM-CSF in the development of autoimmune and inflammatory diseases are gaining increasing attention. This review summarizes the latest knowledge of GM-CSF and its relationship with autoimmune and inflammatory diseases. The potential therapies targeting GM-CSF as well as their possible side effects have also been addressed in this review. |
| format | Article |
| id | doaj-art-83625da3d1694b4bb1fa42bf0e23ce9a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-83625da3d1694b4bb1fa42bf0e23ce9a2025-02-03T06:11:35ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/568543568543Pivotal Roles of GM-CSF in Autoimmunity and InflammationAoi Shiomi0Takashi Usui1Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, JapanDepartment of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, JapanGranulocyte macrophage-colony stimulating factor (GM-CSF) is a hematopoietic growth factor, which stimulates the proliferation of granulocytes and macrophages from bone marrow precursor cells. In autoimmune and inflammatory diseases, Th17 cells have been considered as strong inducers of tissue inflammation. However, recent evidence indicates that GM-CSF has prominent proinflammatory functions and that this growth factor (not IL-17) is critical for the pathogenicity of CD4+ T cells. Therefore, the mechanism of GM-CSF-producing CD4+ T cell differentiation and the role of GM-CSF in the development of autoimmune and inflammatory diseases are gaining increasing attention. This review summarizes the latest knowledge of GM-CSF and its relationship with autoimmune and inflammatory diseases. The potential therapies targeting GM-CSF as well as their possible side effects have also been addressed in this review.http://dx.doi.org/10.1155/2015/568543 |
| spellingShingle | Aoi Shiomi Takashi Usui Pivotal Roles of GM-CSF in Autoimmunity and Inflammation Mediators of Inflammation |
| title | Pivotal Roles of GM-CSF in Autoimmunity and Inflammation |
| title_full | Pivotal Roles of GM-CSF in Autoimmunity and Inflammation |
| title_fullStr | Pivotal Roles of GM-CSF in Autoimmunity and Inflammation |
| title_full_unstemmed | Pivotal Roles of GM-CSF in Autoimmunity and Inflammation |
| title_short | Pivotal Roles of GM-CSF in Autoimmunity and Inflammation |
| title_sort | pivotal roles of gm csf in autoimmunity and inflammation |
| url | http://dx.doi.org/10.1155/2015/568543 |
| work_keys_str_mv | AT aoishiomi pivotalrolesofgmcsfinautoimmunityandinflammation AT takashiusui pivotalrolesofgmcsfinautoimmunityandinflammation |