Spinal Fusion in the Next Generation: Gene and Cell Therapy Approaches
Bone fusion represents a challenge in the orthopedics practice, being especially indicated for spine disorders. Spinal fusion can be defined as the bony union between two vertebral bodies obtained through the surgical introduction of an osteoconductive, osteoinductive, and osteogenic compound. Autog...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/406159 |
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| _version_ | 1832554432934445056 |
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| author | Marta Barba Claudia Cicione Camilla Bernardini Vincenzo Campana Ernesto Pagano Fabrizio Michetti Giandomenico Logroscino Wanda Lattanzi |
| author_facet | Marta Barba Claudia Cicione Camilla Bernardini Vincenzo Campana Ernesto Pagano Fabrizio Michetti Giandomenico Logroscino Wanda Lattanzi |
| author_sort | Marta Barba |
| collection | DOAJ |
| description | Bone fusion represents a challenge in the orthopedics practice, being especially indicated for spine disorders. Spinal fusion can be defined as the bony union between two vertebral bodies obtained through the surgical introduction of an osteoconductive, osteoinductive, and osteogenic compound. Autogenous bone graft provides all these three qualities and is considered the gold standard. However, a high morbidity is associated with the harvest procedure. Intensive research efforts have been spent during the last decades to develop new approaches and technologies for successful spine fusion. In recent years, cell and gene therapies have attracted great interest from the scientific community. The improved knowledge of both mesenchymal stem cell biology and osteogenic molecules allowed their use in regenerative medicine, representing attractive approaches to achieve bone regeneration also in spinal surgery applications. In this review we aim to describe the developing gene- and cell-based bone regenerative approaches as promising future trends in spine fusion. |
| format | Article |
| id | doaj-art-836229c97a494685805434b38cb91687 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-836229c97a494685805434b38cb916872025-02-03T05:51:31ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/406159406159Spinal Fusion in the Next Generation: Gene and Cell Therapy ApproachesMarta Barba0Claudia Cicione1Camilla Bernardini2Vincenzo Campana3Ernesto Pagano4Fabrizio Michetti5Giandomenico Logroscino6Wanda Lattanzi7Institute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, ItalyInstitute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, ItalyInstitute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, ItalyDepartement of Orthopaedics and Traumatology, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168 Rome, ItalyDepartement of Orthopaedics and Traumatology, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168 Rome, ItalyInstitute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, ItalyDepartement of Orthopaedics and Traumatology, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168 Rome, ItalyInstitute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, ItalyBone fusion represents a challenge in the orthopedics practice, being especially indicated for spine disorders. Spinal fusion can be defined as the bony union between two vertebral bodies obtained through the surgical introduction of an osteoconductive, osteoinductive, and osteogenic compound. Autogenous bone graft provides all these three qualities and is considered the gold standard. However, a high morbidity is associated with the harvest procedure. Intensive research efforts have been spent during the last decades to develop new approaches and technologies for successful spine fusion. In recent years, cell and gene therapies have attracted great interest from the scientific community. The improved knowledge of both mesenchymal stem cell biology and osteogenic molecules allowed their use in regenerative medicine, representing attractive approaches to achieve bone regeneration also in spinal surgery applications. In this review we aim to describe the developing gene- and cell-based bone regenerative approaches as promising future trends in spine fusion.http://dx.doi.org/10.1155/2014/406159 |
| spellingShingle | Marta Barba Claudia Cicione Camilla Bernardini Vincenzo Campana Ernesto Pagano Fabrizio Michetti Giandomenico Logroscino Wanda Lattanzi Spinal Fusion in the Next Generation: Gene and Cell Therapy Approaches The Scientific World Journal |
| title | Spinal Fusion in the Next Generation: Gene and Cell Therapy Approaches |
| title_full | Spinal Fusion in the Next Generation: Gene and Cell Therapy Approaches |
| title_fullStr | Spinal Fusion in the Next Generation: Gene and Cell Therapy Approaches |
| title_full_unstemmed | Spinal Fusion in the Next Generation: Gene and Cell Therapy Approaches |
| title_short | Spinal Fusion in the Next Generation: Gene and Cell Therapy Approaches |
| title_sort | spinal fusion in the next generation gene and cell therapy approaches |
| url | http://dx.doi.org/10.1155/2014/406159 |
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