Spectrophotometric Method for the Determination of Nebivolol Hydrochloride in Bulk and Pharmaceutical Formulations
A simple, sensitive, highly accurate spectrophotometric method in UV region has been developed for the determination of nebivolol hydrochloride in bulk and pharmaceutical formulations. Nebivolol hydrochloride is an antihypertensive drug, which shows maximum absorbance at 281 nm with apparent molar a...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/902697 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559360259129344 |
|---|---|
| author | A. Lakshmana Rao K. R. Rajeswari G. G. Sankar |
| author_facet | A. Lakshmana Rao K. R. Rajeswari G. G. Sankar |
| author_sort | A. Lakshmana Rao |
| collection | DOAJ |
| description | A simple, sensitive, highly accurate spectrophotometric method in UV region has been developed for the determination of nebivolol hydrochloride in bulk and pharmaceutical formulations. Nebivolol hydrochloride is an antihypertensive drug, which shows maximum absorbance at 281 nm with apparent molar absorptivity of 5.37208 × 103 mol-1 cm-1. Beer’s law was obeyed in the concentration range of 4-60 μg/mL. The slope, intercept and correlation coefficient were also calculated. The proposed method has been successfully used for the analysis of the drug in pure and its tablet dosage forms. Results of percentage recovery shows that the method was not affected by the presence of common excipients. The percentage assay of nebivolol hydrochloride was 98.75 and 99.02 respectively. The method was validated by sensitivity and precision which proves suitability of proposed method for the routine estimation of nebivolol in bulk and pharmaceutical formulations. |
| format | Article |
| id | doaj-art-835b8fbfc4614c77bfc8826c1f784816 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-835b8fbfc4614c77bfc8826c1f7848162025-02-03T01:30:12ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-017244544810.1155/2010/902697Spectrophotometric Method for the Determination of Nebivolol Hydrochloride in Bulk and Pharmaceutical FormulationsA. Lakshmana Rao0K. R. Rajeswari1G. G. Sankar2Department of Pharmaceutical Analysis, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram-534 202, IndiaDepartment of Pharmaceutical Analysis, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram-534 202, IndiaDepartment of Pharmaceutical Analysis, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram-534 202, IndiaA simple, sensitive, highly accurate spectrophotometric method in UV region has been developed for the determination of nebivolol hydrochloride in bulk and pharmaceutical formulations. Nebivolol hydrochloride is an antihypertensive drug, which shows maximum absorbance at 281 nm with apparent molar absorptivity of 5.37208 × 103 mol-1 cm-1. Beer’s law was obeyed in the concentration range of 4-60 μg/mL. The slope, intercept and correlation coefficient were also calculated. The proposed method has been successfully used for the analysis of the drug in pure and its tablet dosage forms. Results of percentage recovery shows that the method was not affected by the presence of common excipients. The percentage assay of nebivolol hydrochloride was 98.75 and 99.02 respectively. The method was validated by sensitivity and precision which proves suitability of proposed method for the routine estimation of nebivolol in bulk and pharmaceutical formulations.http://dx.doi.org/10.1155/2010/902697 |
| spellingShingle | A. Lakshmana Rao K. R. Rajeswari G. G. Sankar Spectrophotometric Method for the Determination of Nebivolol Hydrochloride in Bulk and Pharmaceutical Formulations E-Journal of Chemistry |
| title | Spectrophotometric Method for the Determination of Nebivolol Hydrochloride in Bulk and Pharmaceutical Formulations |
| title_full | Spectrophotometric Method for the Determination of Nebivolol Hydrochloride in Bulk and Pharmaceutical Formulations |
| title_fullStr | Spectrophotometric Method for the Determination of Nebivolol Hydrochloride in Bulk and Pharmaceutical Formulations |
| title_full_unstemmed | Spectrophotometric Method for the Determination of Nebivolol Hydrochloride in Bulk and Pharmaceutical Formulations |
| title_short | Spectrophotometric Method for the Determination of Nebivolol Hydrochloride in Bulk and Pharmaceutical Formulations |
| title_sort | spectrophotometric method for the determination of nebivolol hydrochloride in bulk and pharmaceutical formulations |
| url | http://dx.doi.org/10.1155/2010/902697 |
| work_keys_str_mv | AT alakshmanarao spectrophotometricmethodforthedeterminationofnebivololhydrochlorideinbulkandpharmaceuticalformulations AT krrajeswari spectrophotometricmethodforthedeterminationofnebivololhydrochlorideinbulkandpharmaceuticalformulations AT ggsankar spectrophotometricmethodforthedeterminationofnebivololhydrochlorideinbulkandpharmaceuticalformulations |