Leukoreduction in a dog with acute leukemia
Abstract A 9‐year‐old male castrated golden retriever cross was evaluated for an acute onset of ataxia. A complete blood count revealed marked leukocytosis, anemia, and thrombocytopenia. Leukocytosis was characterized by marked lymphocytosis, monocytosis, neutropenia, and eosinopenia. Flow cytometry...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.17283 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832584137564749824 |
|---|---|
| author | Brenna Hanratty Anna Hauck Amanda Foskett J. D. Foster |
| author_facet | Brenna Hanratty Anna Hauck Amanda Foskett J. D. Foster |
| author_sort | Brenna Hanratty |
| collection | DOAJ |
| description | Abstract A 9‐year‐old male castrated golden retriever cross was evaluated for an acute onset of ataxia. A complete blood count revealed marked leukocytosis, anemia, and thrombocytopenia. Leukocytosis was characterized by marked lymphocytosis, monocytosis, neutropenia, and eosinopenia. Flow cytometry identified CD34+ leukocytosis with cells that did not express lineage antigens, suggesting the most likely diagnosis of either acute lymphoid or myeloid leukemia. Leukoreduction via leukapheresis was elected to reduce the disease burden before initiating chemotherapy. Postleukoreduction, the dog had a 54% decrease in their white blood cell count. The dog completed multiple weeks of traditional cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP)‐based treatment and had a survival time of 43 days before the owner elected humane euthanasia. To our knowledge, this report represents a case of acute leukemia in a dog treated with leukoreduction before starting chemotherapy. |
| format | Article |
| id | doaj-art-833e99c54d6241059c0e2efe418e405c |
| institution | Kabale University |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-833e99c54d6241059c0e2efe418e405c2025-01-27T15:22:41ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762025-01-01391n/an/a10.1111/jvim.17283Leukoreduction in a dog with acute leukemiaBrenna Hanratty0Anna Hauck1Amanda Foskett2J. D. Foster3Friendship Hospital for Animals Washington District of Columbia USAFriendship Hospital for Animals Washington District of Columbia USAFriendship Hospital for Animals Washington District of Columbia USAFriendship Hospital for Animals Washington District of Columbia USAAbstract A 9‐year‐old male castrated golden retriever cross was evaluated for an acute onset of ataxia. A complete blood count revealed marked leukocytosis, anemia, and thrombocytopenia. Leukocytosis was characterized by marked lymphocytosis, monocytosis, neutropenia, and eosinopenia. Flow cytometry identified CD34+ leukocytosis with cells that did not express lineage antigens, suggesting the most likely diagnosis of either acute lymphoid or myeloid leukemia. Leukoreduction via leukapheresis was elected to reduce the disease burden before initiating chemotherapy. Postleukoreduction, the dog had a 54% decrease in their white blood cell count. The dog completed multiple weeks of traditional cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP)‐based treatment and had a survival time of 43 days before the owner elected humane euthanasia. To our knowledge, this report represents a case of acute leukemia in a dog treated with leukoreduction before starting chemotherapy.https://doi.org/10.1111/jvim.17283chemotherapyhyperleukocytosisleukapheresislymphoblastoncologyveterinary |
| spellingShingle | Brenna Hanratty Anna Hauck Amanda Foskett J. D. Foster Leukoreduction in a dog with acute leukemia Journal of Veterinary Internal Medicine chemotherapy hyperleukocytosis leukapheresis lymphoblast oncology veterinary |
| title | Leukoreduction in a dog with acute leukemia |
| title_full | Leukoreduction in a dog with acute leukemia |
| title_fullStr | Leukoreduction in a dog with acute leukemia |
| title_full_unstemmed | Leukoreduction in a dog with acute leukemia |
| title_short | Leukoreduction in a dog with acute leukemia |
| title_sort | leukoreduction in a dog with acute leukemia |
| topic | chemotherapy hyperleukocytosis leukapheresis lymphoblast oncology veterinary |
| url | https://doi.org/10.1111/jvim.17283 |
| work_keys_str_mv | AT brennahanratty leukoreductioninadogwithacuteleukemia AT annahauck leukoreductioninadogwithacuteleukemia AT amandafoskett leukoreductioninadogwithacuteleukemia AT jdfoster leukoreductioninadogwithacuteleukemia |