Therapeutic Potential of 5-HT2C Receptor Ligands
Serotonin 2C receptors are G protein-coupled receptors expressed by GABAergic, glutamatergic, and dopaminergic neurons. Anatomically, they are present in various brain regions, including cortical areas, hippocampus, ventral midbrain, striatum, nucleus accumbens, hypothalamus, and amygdala. A large b...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.180 |
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| author | Nanna H. Jensen Thomas I. Cremers Florence Sotty |
| author_facet | Nanna H. Jensen Thomas I. Cremers Florence Sotty |
| author_sort | Nanna H. Jensen |
| collection | DOAJ |
| description | Serotonin 2C receptors are G protein-coupled receptors expressed by GABAergic, glutamatergic, and dopaminergic neurons. Anatomically, they are present in various brain regions, including cortical areas, hippocampus, ventral midbrain, striatum, nucleus accumbens, hypothalamus, and amygdala. A large body of evidence supports a critical role of serotonin 2C receptors in mediating the interaction between serotonergic and dopaminergic systems, which is at the basis of their proposed involvement in the regulation of mood, affective behavior, and memory. In addition, their expression in specific neuronal populations in the hypothalamus would be critical for their role in the regulation of feeding behavior. Modulation of these receptors has therefore been proposed to be of interest in the search for novel pharmacological strategies for the treatment of various pathological conditions, including schizophrenia and mood disorders, as well as obesity. More precisely, blockade of serotonin 2C receptors has been suggested to provide antidepressant and anxiolytic benefit, while stimulation of these receptors may offer therapeutic benefit for the treatment of psychotic symptoms in schizophrenia and obesity. In addition, modulation of serotonin 2C receptors may offer cognitive-enhancing potential, albeit still a matter of debate. In the present review, the most compelling evidence from the literature is presented and tentative hypotheses with respect to existing controversies are outlined. |
| format | Article |
| id | doaj-art-833df36f32df493abb1a6c063be273c4 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-833df36f32df493abb1a6c063be273c42025-02-03T06:06:58ZengWileyThe Scientific World Journal1537-744X2010-01-01101870188510.1100/tsw.2010.180Therapeutic Potential of 5-HT2C Receptor LigandsNanna H. Jensen0Thomas I. Cremers1Florence Sotty2Department of Neurophysiology, H. Lundbeck A/S, Copenhagen-Valby, DenmarkBrains On-Line LLC, South San Francisco, CA, USADepartment of Neurophysiology, H. Lundbeck A/S, Copenhagen-Valby, DenmarkSerotonin 2C receptors are G protein-coupled receptors expressed by GABAergic, glutamatergic, and dopaminergic neurons. Anatomically, they are present in various brain regions, including cortical areas, hippocampus, ventral midbrain, striatum, nucleus accumbens, hypothalamus, and amygdala. A large body of evidence supports a critical role of serotonin 2C receptors in mediating the interaction between serotonergic and dopaminergic systems, which is at the basis of their proposed involvement in the regulation of mood, affective behavior, and memory. In addition, their expression in specific neuronal populations in the hypothalamus would be critical for their role in the regulation of feeding behavior. Modulation of these receptors has therefore been proposed to be of interest in the search for novel pharmacological strategies for the treatment of various pathological conditions, including schizophrenia and mood disorders, as well as obesity. More precisely, blockade of serotonin 2C receptors has been suggested to provide antidepressant and anxiolytic benefit, while stimulation of these receptors may offer therapeutic benefit for the treatment of psychotic symptoms in schizophrenia and obesity. In addition, modulation of serotonin 2C receptors may offer cognitive-enhancing potential, albeit still a matter of debate. In the present review, the most compelling evidence from the literature is presented and tentative hypotheses with respect to existing controversies are outlined.http://dx.doi.org/10.1100/tsw.2010.180 |
| spellingShingle | Nanna H. Jensen Thomas I. Cremers Florence Sotty Therapeutic Potential of 5-HT2C Receptor Ligands The Scientific World Journal |
| title | Therapeutic Potential of 5-HT2C Receptor Ligands |
| title_full | Therapeutic Potential of 5-HT2C Receptor Ligands |
| title_fullStr | Therapeutic Potential of 5-HT2C Receptor Ligands |
| title_full_unstemmed | Therapeutic Potential of 5-HT2C Receptor Ligands |
| title_short | Therapeutic Potential of 5-HT2C Receptor Ligands |
| title_sort | therapeutic potential of 5 ht2c receptor ligands |
| url | http://dx.doi.org/10.1100/tsw.2010.180 |
| work_keys_str_mv | AT nannahjensen therapeuticpotentialof5ht2creceptorligands AT thomasicremers therapeuticpotentialof5ht2creceptorligands AT florencesotty therapeuticpotentialof5ht2creceptorligands |