The pivotal regulatory role of the FEV-SLC7A11 axis in ferroptosis elucidates the anti-aging mechanism of β-sitosterol in a cross-species study

The pivotal regulatory role of the FEV-SLC7A11 axis in ferroptosis elucidates the anti-aging mechanism of β-sitosterol in a cross-species study

Traditional Chinese medicine is a valuable source of bioactive compounds for combating aging. Among these, β-sitosterol (BS), a sterol extracted from Alpiniae oxyphyllae fructus, has attracted attention for its potent antioxidant, anti-inflammatory, and free radical scavenging properties. However, i...

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Bibliographic Details
Main Authors: Zhihan Fang, Liyao Xie, Jing Wang, Junyi Li, Yirui Pan, Lei Chen, Shuyi Cao, Qi Zhou, Shaobin Li, Chao Zhang, Li Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
β-sitosterol
ferroptosis
oxidative stress
cellular senescence
FEV
cross-species comparison
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1600489/full
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