Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosis

Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosis

Abstract Musculoskeletal disorders (MSDs), notably sarcopenia and osteoporosis, profoundly affect aging individuals. This review explores lipid metabolism's role in age-related MSD pathophysiology, highlighting fatty acid uptake, lipid signaling, and lipotoxicity in muscle deterioration. It fur...

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Bibliographic Details
Main Authors: Shivum Lal, Shreya Gunji, Pankaj Ahluwalia, Ravindra Kolhe, Wendy B. Bollag, William D. Hill, Meghan E. McGee-Lawrence, Carlos M. Isales, Sadanand Fulzele
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Biology
Subjects:
Lipid Metabolism
Aging
Musculoskeletal
Sarcopenia
Osteoporosis
Online Access:https://doi.org/10.1186/s12915-025-02383-9
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