Concentration Kinetics of Serum MMP-9 and TIMP-1 after Blunt Multiple Injuries in the Early Posttraumatic Period
Metalloproteinases are secreted in response to a variety of inflammatory mediators and inhibited by tissue inhibitors of matrixmetalloproteinases (TIMPs). Two members of these families, MMP-9 and TIMP-1, were differentially expressed depending on clinical parameters in a previous genomewide mRNA ana...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/435463 |
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| author | M. Brumann T. Kusmenkov L. Ney K.-G. Kanz B. A. Leidel P. Biberthaler W. Mutschler V. Bogner |
| author_facet | M. Brumann T. Kusmenkov L. Ney K.-G. Kanz B. A. Leidel P. Biberthaler W. Mutschler V. Bogner |
| author_sort | M. Brumann |
| collection | DOAJ |
| description | Metalloproteinases are secreted in response to a variety of inflammatory mediators and inhibited by tissue inhibitors of matrixmetalloproteinases (TIMPs). Two members of these families, MMP-9 and TIMP-1, were differentially expressed depending on clinical parameters in a previous genomewide mRNA analysis. The aim of this paper was now to evaluate the posttraumatic serum levels and the time course of both proteins depending on distinct clinical parameters. 60 multiple traumatized patients (ISS > 16) were included. Blood samples were drawn on admission and 6 h, 12 h, 24 h, 48 h, and 72 h after trauma. Serum levels were quantified by ELISA. MMP-9 levels significantly decreased in the early posttraumatic period (P<0.05) whereas TIMP-1 levels significantly increased in all patients (P<0.05). MMP-9 and TIMP-1 serum concentration kinetics became manifest in an inversely proportional balance. Furthermore, MMP-9 presented a stronger decrease in patients with severe trauma and non-survivors in contrast to minor traumatized patients (ISS ≤ 33) and survivors, initially after trauma. |
| format | Article |
| id | doaj-art-831ed67db5af4b0080e353d97914450e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-831ed67db5af4b0080e353d97914450e2025-02-03T05:59:38ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/435463435463Concentration Kinetics of Serum MMP-9 and TIMP-1 after Blunt Multiple Injuries in the Early Posttraumatic PeriodM. Brumann0T. Kusmenkov1L. Ney2K.-G. Kanz3B. A. Leidel4P. Biberthaler5W. Mutschler6V. Bogner7Chirurgische Klinik und Poliklinik-Innenstadt, Ludwig-Maximilians University, 80336 Munich, GermanyChirurgische Klinik und Poliklinik-Innenstadt, Ludwig-Maximilians University, 80336 Munich, GermanyChirurgische Klinik und Poliklinik-Innenstadt, Ludwig-Maximilians University, 80336 Munich, GermanyChirurgische Klinik und Poliklinik-Innenstadt, Ludwig-Maximilians University, 80336 Munich, GermanyDepartment of Emergency Medicine, Campus Benjamin Franklin, Charité-University Medical Centre, 12203 Berlin, GermanyKlinik und Poliklinik für Unfallchirurgie, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, GermanyChirurgische Klinik und Poliklinik-Innenstadt, Ludwig-Maximilians University, 80336 Munich, GermanyChirurgische Klinik und Poliklinik-Innenstadt, Ludwig-Maximilians University, 80336 Munich, GermanyMetalloproteinases are secreted in response to a variety of inflammatory mediators and inhibited by tissue inhibitors of matrixmetalloproteinases (TIMPs). Two members of these families, MMP-9 and TIMP-1, were differentially expressed depending on clinical parameters in a previous genomewide mRNA analysis. The aim of this paper was now to evaluate the posttraumatic serum levels and the time course of both proteins depending on distinct clinical parameters. 60 multiple traumatized patients (ISS > 16) were included. Blood samples were drawn on admission and 6 h, 12 h, 24 h, 48 h, and 72 h after trauma. Serum levels were quantified by ELISA. MMP-9 levels significantly decreased in the early posttraumatic period (P<0.05) whereas TIMP-1 levels significantly increased in all patients (P<0.05). MMP-9 and TIMP-1 serum concentration kinetics became manifest in an inversely proportional balance. Furthermore, MMP-9 presented a stronger decrease in patients with severe trauma and non-survivors in contrast to minor traumatized patients (ISS ≤ 33) and survivors, initially after trauma.http://dx.doi.org/10.1155/2012/435463 |
| spellingShingle | M. Brumann T. Kusmenkov L. Ney K.-G. Kanz B. A. Leidel P. Biberthaler W. Mutschler V. Bogner Concentration Kinetics of Serum MMP-9 and TIMP-1 after Blunt Multiple Injuries in the Early Posttraumatic Period Mediators of Inflammation |
| title | Concentration Kinetics of Serum MMP-9 and TIMP-1 after Blunt Multiple Injuries in the Early Posttraumatic Period |
| title_full | Concentration Kinetics of Serum MMP-9 and TIMP-1 after Blunt Multiple Injuries in the Early Posttraumatic Period |
| title_fullStr | Concentration Kinetics of Serum MMP-9 and TIMP-1 after Blunt Multiple Injuries in the Early Posttraumatic Period |
| title_full_unstemmed | Concentration Kinetics of Serum MMP-9 and TIMP-1 after Blunt Multiple Injuries in the Early Posttraumatic Period |
| title_short | Concentration Kinetics of Serum MMP-9 and TIMP-1 after Blunt Multiple Injuries in the Early Posttraumatic Period |
| title_sort | concentration kinetics of serum mmp 9 and timp 1 after blunt multiple injuries in the early posttraumatic period |
| url | http://dx.doi.org/10.1155/2012/435463 |
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